For systemic delivery, the oral route has been the preferred route of administration for many systemic actively drugs. When administered by the oral route, however, many therapeutic agents have been reportedly subjected to extensive presystemic elimination by gastrointestinal degradation and/or hepatic metabolism. Results of low systemic bioavailability, short duration of therapeutic activity, and/or formation of toxic and inactive metabolite. The unique environment of the oral cavity offers its potential as a site for drug delivery. Because of rich blood supply and direct access to systemic circulation, the oral mucosal route is suitable for drugs, which are susceptible to acid hydrolysis in the stomach or which are extensively metabolized in the liver.

Stress is one of the leading causes of anxiety and depression disease, endocrine disease, gastrointestinal and metabolic disorder due to internal and external stressor in both developed and developing countries. Some drugs which are uses to treatment of stress themselves causes mental depression. Hence it is imperative to find out drugs with minimum side effect and for its effective adaptogenic activity. Glycyrrhiza glabra has been known to traditional medicinal system for its adaptogenic activity. Present study was undertaken scientifically to evaluate adaptogenic activity of Glycyrrhiza glabra roots.