Now in its 8th year, the Sol Plaatje European Union Poetry Award has been the launching pad for upcoming poets. From slam poetry to formal rhyme, the anthology is a celebration of language and cultural diversity. Assembled by a brilliant team of judges, from a blind selection, this year's compilation contains the best poems from 500 entries, including 10 of the 11 South African languages. Named after Solomon Tshekisho Plaatje (1876-1932), the award recognises the life and vision of this highly respected political and social activist. We always hope that it reveals the political and social attitudes of our time and reflects the complex, nuanced and uncomfortable truths of life in South Africa.

A Practical Guide to 3D Ultrasound was conceived with the beginner in mind. The guide summarizes the basics of 3D sonography in a concise manner and serves as a practical reference for daily practice. It is written in easy-to-read language and contains tables summarizing the step-by-step instructions for the techniques presented. Following introductory chapters covering the various technical aspects of 3D ultrasound, the book covers clinical applications of 3D ultrasound in the first trimester and for the fetal cardiovascular, genitourinary, and central nervous systems. Clinical applications of fetal anatomical structures such as the skeleton, chest, face, and gastrointestinal tract are also discussed. In addition, the clinical applicability of 3D ultrasound in obstetrics and gynecology is explored. The book is highly illustrated and contains more than 350 ultrasound images, many in color, corresponding to the techniques discussed. A table of practical tips is also included at the end of every chapter. This book is a practical and comprehensive reference for the basics surrounding 3D ultrasound.

Whether you're a newly diagnosed ovarian cancer patient, a survivor, or a friend or relative of either, this book offers help. Completely updated, the new fourth edition of 100 Questions & Answers About Ovarian Cancer gives you authoritative, practical answers to your questions about treatment options, post-treatment quality of life, sources of support, and much more. Written by a gynecologic oncologist and a gynecologic surgeon, with actual patient commentary, this book is an invaluable resource for anyone coping with the physical and emotional turmoil of this frightening disease.

The therapeutic efficacy of FUra has been attributed to its incorporation into cellular RNA and, to its inhibition of thymidylate synthase, leading to potent inhibition of DNA synthesis and DNA damage. Studies of cell lines in vitro and model systems in vivo have demonstrated that although mechanisms of sensitivity and resistance to FUra are multifactorial, in the presence of citrovorum factor (LV, CF, 5-formyltetrahydrofolate) the site of action of FUr a becomes predominantly the pronounced and prolonged inhibition of thymidylate synthase. This action is the result of stabilization of the covalent ternary complex between FdUMP, an active metabolite of FUr a, 5, IO-methylenetetrahydrofolates, and thymidylate synthase. This effect of LV is thus an example of the concept of metabolic modulation. CF is commercially available as a racemic mixture of diastereoisomers (6R and 6S). The 6R isomer is considered to be biologically inactive; the 6S isomer is the biologically active form that is metabolized intracellularly to' form the various folate cofactor pools including 5, IO-methylenetetrahydrofolates. Although the extent of metabolism of folates in normal and tumor tissues has not been clearly delineated, it has been determined that the formation of folypolyglutamates is primarily a function of schedule of CF administration, while the retention of significant concentrations of reduced folate is a function of the dose and also the schedule of LV. Thus, it appears that for optimal modulation of FUra activity several factors must be considered simultaneously.

Although 5-fluorouracil (Fura) is the drug of choice for the treat- ment of patients with advanced colorectal cancer, this agent has limited effectiveness with a reported response rate of 10-20% and a duration of response of only 6-9 months. The large percentage of treatment failures with this agent has spurred a continuing effort to delineate the mechanism(s) of resistance to Fura and to evaluate approaches that would selectively modulate the therapeutic efficacy of this agent. The therapeutic efficacy of FUra has been attributed to its selec- tive incorporation into RNA and to its inhibition of thymidylate syn- thase, leading to potent inhibition of DNA synthesis. Studies of cell lines in vitro and model systems in vivo have demonstrated that although mechanism sensitivity and resistanc; to Fura are multifactorial, in the presence of citrovorum factor (CF, 5-formyltetrahydrofolate) the site of action of Fura becomes predominantly the pronounced and pro- longed inhibition of thymidylate synthase. This action is the result of stabilization of the covalent ternary complex between FdUMP, an active metabolite of FUra, 5,10-methylenetetrahydrofolates, and thymidylate synthase. This effect of CF is thus an example of the concept of meta- bolic modulation.

Leading cancer researchers update and review the mechanisms of action and the therapeutic selectivity and efficacy of 5-FU with and without leucovorin and its prodrugs in the treatment of colorectal cancer. Among the combination agents considered are UFT/LV, 5-FU/EU, capecitabine (Xeloda), S-1, and a variety of thymidylate synthase inhibitors. The authors discuss the potential advantages and disadvantages of these varied drugs and their mode of administration. Based on historical results with these agents when used alone, they also present a rationale for their results when used in combination with other agents.

Leading cancer researchers update and review the mechanisms of action and the therapeutic selectivity and efficacy of 5-FU with and without leucovorin and its prodrugs in the treatment of colorectal cancer. Among the combination agents considered are UFT/LV, 5-FU/EU, capecitabine (Xeloda), S-1, and a variety of thymidylate synthase inhibitors. The authors discuss the potential advantages and disadvantages of these varied drugs and their mode of administration. Based on historical results with these agents when used alone, they also present a rationale for their results when used in combination with other agents.

With an emphasis on a practical, "how-to" approach, this comprehensive text addresses the most important and commonly performed procedures in gynecologic oncology surgery today. Written by leaders in the field, Principles of Gynecologic Oncology Surgery clearly describes the critical steps for each procedure, provides up-to-date information on the recent literature, and includes high-quality illustrations of anatomy and technique. Covers hot topics such as Enhanced Recovery After Surgery (ERAS), sentinel lymph node mapping, and minimally invasive surgery (robotic surgery, advanced laparoscopic surgery, and single site surgery). Includes expert coverage of reconstructive surgery, colorectal surgery, urology, and vascular surgery, each written by surgeon leaders in that particular field. Addresses the diagnosis, management and prevention of surgical complications. Features videos online that guide you through a multitude of procedures, including abdominal exploration using laparoscopy for evaluation of cytoreduction in advanced ovarian cancer, laparoscopic hysterectomies with sentinel lymph node mapping, radical hysterectomy, robotic radical trachelectomy, and more. Expert ConsultT eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, Q&As, and references from the book on a variety of devices.

Whether you're a newly diagnosed ovarian cancer patient, a survivor, or a friend or relative of either, this book offers help. Completely updated, the new third edition of 100 Questions & Answers About Ovarian Cancer gives you authoritative, practical answers to your questions about treatment options, post-treatment quality of life, sources of support, and much more. Written by a gynecologic oncologist and a gynecologic surgeon, with actual patient commentary, this book is an invaluable resource for anyone coping with the physical and emotional turmoil of this frightening disease.

The need to protect the natural environment from pollution from point sources has fuelled the development of mathematical models for predicting the performance of such systems. Previous attempts at mathematical modeling of wastewater treatment have focused on the use of mechanistic models which rely on the detailed specification of the physics of the various biochemical reactions and their numerous parameters. This is a problem because the huge amounts of data needed for calibrating such models are often unavailable, which together with imprecision in model structure identification, results in uncertainties. This book has catalogued a new approach to the problem using artificial intelligence methods that are essentially data driven. In particular, the book through practical case studies has demonstrated the feasibility of AI techniques such as ANN, Fuzzy logic and hybrids of these in wastewater management. The book will be suitable for students and researchers in environmental engineering, practitioners and consultants on wastewater treatment projects, and indeed anyone faced with the task of analyzing, and understanding embedded knowledge in large arrays of data.

Whether you're a newly diagnosed ovarian cancer patient, a survivor, or a friend or relative of either, this book offers help. Completely updated, the new second edition of 100 Questions & Answers About Ovarian Cancer gives you authoritative, practical answers to your questions about treatment options, post-treatment quality of life, sources of support, and much more. Written by a gynecologic oncologist and a gynecologic surgeon, with actual patient commentary, this book is an invaluable resource for anyone coping with the physical and emotional turmoil of this frightening disease.

Papers and reports of research and clinical studies on the effectiveness of treatment modalities, alternative healing devices, energy medicine, and the wide variety of CAM-WPH practices.

Papers and reports of research and clinical studies on the effectiveness of treatment modalities, alternative healing devices, energy medicine, and the wide variety of CAM-WPH practices.

Papers and reports of research and clinical studies on the effectiveness of treatment modalities, alternative healing devices, energy medicine, and the wide variety of CAM-WPH practices.

This book is one of a pair, the second to appear later in 2003. It sets the stage by describing how the small Sycamore (spiritual) Community tried to steer the dominant (Judaeo)-Christian culture of the postwar West in the 1970 s in the area of sexual ethics.

Since then the greatest social revolution in human history has occurred. The rise of the feminine and the re-ification (obviously still a work in progress) of the equality in both opportunity (and soon, power) of women has occurred. Simultaneously, the public acceptance of homosexuality and the variety in sexual orientation of a minority has also been dramatic. What has not yet happened is the mainstream acceptance of variety in the accepted sexual patterns of the majority (largely married) population.

Mainstream traditionalists are likely to find this book more acceptable now. Readers from the cultural avant-garde will remember and reminisce about an era they left behind a generation ago. Guidelines for the early 21st century, to be found in the sequel, may be compared with these.

Fluoropyrimidine Metabolism and Mechanism of Action.- 5-Fluoro-2?-Deoxyuridine: Role of Schedule in its Therapeutic Efficacy.- Comparison of Continuous Infusions and Bolus Injections of 5- Fluorouracil with or without Leucovorin: Implications for Inhibition of Thymidylate Synthase.- Critical Questions for the Future Direction of FU/LV.- Cellular Interactions Between the Natural and Unnatural Isomers of 5-Formyltetrahydrofolate.- Leucovorin as a Prodrug.- Clinical Use of Leucovorin: Intracellular Metabolism.- Some Considerations Concerning the Dose and Schedule of 5FU and Leucovorin: Toxicities of Two Dose Schedules from the Intergroup Colon Adjuvant Trial (INT-0089).- Effects of 5-Fluorouracil on mRNA.- Genetic Variation in Thymidylate Synthase Confers Resistance to 5-Fluorodeoxyuridine.- Experience with 5FU + L-Leucovorin.- 5-Fluorouracil Combined with the Pure [6S]-Stereoisomer of Folinic Acid in High Doses for Treatment of Patients with Advanced Colorectal Carcinoma: A Phase I-II Study of Two Consecutive Regimens.- 5-Fluorouracil Modulation in Colorectal Carcinoma: Experience of German Investigators.- An Overview of Adjuvant Treatment of Colon Cancer.- Dose-Dependent Inhibition of Aspartate Carbamoyltransferase in Peripheral Blood Mononuclear Cells in Patients Receiving N-Phosphonacetyl)-L-Aspartate.- Alternative Approaches to Modulation of Fluoropyrimidines.- Increasing the Efficacy of 5-Fluorouracil with Interferons: Preclinical, Clinical, and Pharmacokinetic Studies.- Enchanced Cytotoxicity of 5-Fluorouracil Combined with [6RS]-Leucovorin and Recombinant Human Interferon-?2a in Colon Carcinoma Cells.- Regulation of Thymidylate Synthase in Human Colon Cancer Cells Treated with 5-Fluorouracil and Interferon-Gamma.- Biochemical Modulation of 5-Fluorouracil by PALA: Mechanism of Action.- Implications of Chronobiology for 5-Fluorouracil (5-FU) Efficacy.- Update on Metabolic Modulation as a Therapeutic Approach for Adult Carcinomas.- Fluorouracil and Leucovorin in Advanced Breast Cancer.- Fluorouracil Modulation in Head and Neck Cancer.- Biomodulation in Head and Neck Carcinomas: Therapeutic Approaches in Europe.- Rationale for the Combination Therapy of 5FU and CDDP.- Biochemical Modulation of Fluoropyrimidines: The "Giscad" Studies.- New Drugs.- Clinical Experience with UFT in Japan.- Clinical Studies of the Modulation of Ftorafur.- The Role of the Reduced-Folate Carrier and Metabolism to Intracellular Polyglutamates for the Activity of ICI D1694.- The History of the Development and Clinical Use of CB 3717 and ICI D1694.- New Sites of Intervention in the Development of New Drugs in Solid Tumors.- P53: A Determinant of the Cell Cycle Response to DNA Damage.- Therapeutic Implications of Molecular Genetics.- Concluding Remarks.- Summary.- Abbreviations.- Author Index.

While partial differential equations (PDEs) are fundamental in mathematics and throughout the sciences, most undergraduate students are only exposed to PDEs through the method of separation of variations. This text is written for undergraduate students from different cohorts with one sole purpose: to facilitate a proficiency in many core concepts in PDEs while enhancing the intuition and appreciation of the subject. For mathematics students this will in turn provide a solid foundation for graduate study. A recurring theme is the role of concentration as captured by Dirac's delta function. This both guides the student into the structure of the solution to the diffusion equation and PDEs involving the Laplacian and invites them to develop a cognizance for the theory of distributions. Both distributions and the Fourier transform are given full treatment. The book is rich with physical motivations and interpretations, and it takes special care to clearly explain all the technical mathematical arguments, often with pre-motivations and post-reflections. Through these arguments the reader will develop a deeper proficiency and understanding of advanced calculus. While the text is comprehensive, the material is divided into short sections, allowing particular issues/topics to be addressed in a concise fashion. Sections which are more fundamental to the text are highlighted, allowing the instructor several alternative learning paths. The author's unique pedagogical style also makes the text ideal for self-learning.

A core text from the renowned Memorial Sloan-Kettering Cancer Center, Atlas of Procedures in Gynecologic Oncology, Third Edition covers the latest developments in both open and minimally invasive surgery. Supplemented with full-color photographs, practical explanations, and video clips, the book provides a detailed overview of the major gynecologic oncology procedures. With expanded topics to include more areas of interest, the book continues its tradition of emphasizing technique and surgical approach. Topics include: * Conization, surgical staging, vulvar surgery, and radical hysterectomy * Paracentesis, chest tube placement, and central venous access * Sentinel node mapping and minimally invasive lymph node dissection * Intraoperative radiation therapy, inguinofemoral lymphadenectomy, and myocutaneous flap reconstruction * Nerve-sparing approaches, laterally extended parametrectomy, and urinary diversion * Peritoneal surface malignancy surgery, including heated intraperitoneal chemotherapy application In addition to the commonly performed procedures, the book also illustrates many advanced techniques currently in use only at specialized centers throughout the world. This comprehensive atlas presents the insight of national and international leaders in gynecologic oncology, making it an essential resource for a broad- based audience, including medical students, those beginning their surgical training, and senior practitioners.

"This work is totally original; indeed, it pioneers a new field. . . . A remarkable account of a dimension of war that is much neglected. . . . It is deeply passionate yet non-judgmental. It raises profound questions about the pacific 'nature' of women as they find themselves in the painful circumstance of contradiction and crisis. This book truly becomes an historical record of these tragic years."--Richard A. Lobban, Jr., Rhode Island College

These authors examine the impact on women of the 1975-90 civil war in Lebanon, the lengthiest and bloodiest in its recent history. While they describe war as a more potent oppressor of women than of men, they also credit it with offering women liberation from all forms of social strictures. The authors also refute the assumption that women are pacifists by nature, contending that women are as aggressive and militarily active as men, given the same conditions.

I. Introduction
1. Introduction
2. History of the War
3. Women before the War
II. The Public Sphere
4. Women in the Public Sphere, by Lamia Rustum Shehadeh
III. Creative Women
5. Mapping Peace, by Miriam Cooke
6. A Panorama of Lebanese Women Writers, 1975-1995, by Mona Takieddine Amyuni
7. Lebanon Mythologized or Lebanon Deconstructed: Two Narratives of National Consciousness, by Elise Salem Manganaro
8. Art, the Chemistry of Life, by Lamia Rustum Shehadeh
IV. Women at War
9. Women in the Lebanese Militias, by Lamia Rustum Shehadeh
10. Lebanese Shii Women and Islamism: A Response to War, by Maria Holt
11. Maman Aida--A Lebanese Godmother of the Combatants, by Kari H. Karame
12. From Gunpowder to Incense, by Jocelyn Khweiri
V. Foreign Women
13. Profiles of Foreign Women in Lebanon during the Civil War, by Mary Bentley Abu Saba
VI. Psychological Sequelae
14. War Trauma and Women, by Leila Farhood
15. Women and the Lebanon Wars: Depression and Post-Traumatic Stress Disorder, by Elie G. Karam
16. Gender Dual Diagnosis of Psychiatric Illness and Substance Abuse, by P. Yabroudi, E. G. Karam, A. Chami, A. Karam, M. Majdalani, and V. Zebouni
VII. Conclusion
A War of Survival, by E. G. Karam, N. Melhem and S. Saliba

Lamia Rustum Shehadeh is associate professor of cultural studies at the American University of Beirut. She is the editor of several collections of writings of the Arab historian Asad J. Rustum and has published articles in "International Journal of Middle Eastern Studies, Al-Raida," and "Feminist Issues."