In recent years many multinational enterprises have increased the amount of their R and D performed in dispersed locations overseas. In some cases this aims to provide improved products and processes for host countries and in others to establish internationally integrated programmes of more basic work taping into geographically dispersed sources of scientific expertise. The detailed survey and interview results reported in this volume provide the basis for a detailed discussion of issues relating to both parent company perspectives on such dispersed R and D, and the viewpoints of the overseas "subsidiary" laboratories performing such work. The issues covered include, the nature of the work done in overseas facilities; the specialization of roles in geological R and D; co-ordination practices; sources of ideas implemented in R and D programmes; sources of funding in overseas R and D; attitudes to government policies. Another key concern of the book is to analyse the consequences of the spread of R and D by MNES for the various countries in which they operate.

This book highlights current business practices in the emerging markets of China, Ghana, India, Kenya, Nigeria and UAE, and explains how global competition has created a culture of competitiveness and an era of consumerism. The region-specific issues, tested theories, and empirical evidence make the book of value to both researchers and managers.

Make friends and sell things to people through social media Social media technology is restlessly inventive, providing thousands of awesome ways for you to market your business inexpensively and on a large scale--often directly into the pockets of consumers. But in the proliferating, ever-changing world of tweets, influencers, handles, and alerts, it can be hard to know where to begin and then to evaluate what's actually working for you. In the new edition of Social Media Marketing for Dummies, leading SMM voices Shiv Singh and Stephanie Diamond clear away the confusion and show you the smartest, most effective ways to plan, launch, manage, and assess your campaigns--and then iterate and optimize for increased success. Incorporating the latest trends and presented in a friendly, easily digestible step-by-step style, you'll find the ultimate blueprint for developing your best SMM strategy. In no time, you'll find out how to line up with Facebook, Twitter, Tumblr, and Google, develop a unique and compelling voice, and influence your key audience all the way to the bank. Choose the best SMM combination for you Avoid common mistakes and pitfalls Track your customers from awareness to retention Try out the latest stuff that really works Whether your organization is large or small, it simply doesn't pay to be shy. Find your voice, get social, and chat your way to attracting and keeping new customers today!

Plant bioactive compounds are plant-based natural products that display a variety of pharmacological applications. These bioactive compounds are important as medicines, pigments and flavorings since most of the pharmaceutical industries are highly dependent on medicinal plants and their extraction. The types and concentrations of bioactive compounds produced by plants are determined by the species, genotype, physiology, developmental stage and environmental factors during growth, determining the physiological adaptive responses employed by various plant taxonomic groups in coping with the stress and defensive stimuli. In the past two decades there has been a renewed interest in the study of conventional aspects such as elicitors and biotic and abiotic stress factors that influence secondary metabolism during in vitro and in vivo growth of plants. the application of molecular biology tools and techniques are facilitating increased understanding of the signaling processes and pathways involved in the bioactive compounds production in subcellular, cellular, organ and whole plant systems during in vivo and in vitro growth, with application in the metabolic engineering of biosynthetic pathways intermediates. Biosynthesis and Manipulation of Bioactive compounds in Medicinal and Aromatic Plants provides a comprehensive introduction and review of the state-of-the-art biotechnological tools used in enhancement of bioactive compounds in medicinal and aromatic plants. Readers will find a systematic overview of techniques such as Omics, Crisper /Cas9 and RNAi to enhance plant bioactive contents including various in vitro techniques, hairy root culture and transgenic technology to enhance plant bioactive contents using plant tissue culture approaches. The chapters provide an overview of the role of induced mutation, biotic and abiotic stress to increase the bioactive contents in plants, plus the role of endophytes to enhance the contents of plant bioactive compounds and standard operating procedures using hydroponics system of cultivation for significant enhancement of bioactive compounds. This book serves as a single source for researchers working in plant secondary metabolites and the pharmaceutical industry.

This book discusses why specific diseases are being targeted for cell-based retinal therapy, what evidence exists that justifies optimism for this approach, and what challenges must be managed in order to bring this technology from the laboratory into routine clinical practice. There are a number of unanswered questions (e.g., surgical approach to cell delivery, management of immune response, optimum cell type to transplant) that very likely are not going to be answered until human trials are undertaken, but there is a certain amount of "de-risking" that can be done with preclinical experimentation. This book is essential reading for scientists, clinicians, and advanced students in stem cell research, cell biology, and ophthalmology.

Barack Obama's foreign policy has failed but the American strategic mind has not yet closed. In After Obama, Robert Singh examines how and why US influence has weakened and contributed to the erosion of the world America made, endangering international order and liberal values. A well-intentioned but naive strategy of engagement has encouraged US adversaries such as Russia, China and Iran to assert themselves while allowing Western alliances to fray. But, challenging claims of an inevitable American decline, Singh argues that US leadership is a matter of will as much as wallet. Despite partisan polarization at home and the rise of the rest abroad, Washington can renew American leadership and, through a New American Internationalism, pave a path to the restoration of global order. Timely and provocative, the book offers a powerful critique of the Obama Doctrine and a call for strategic resolution in place of 'leading from behind'.

Most of us take our mental health for granted. But when confronted by mental illness in our family, our friends, or ourselves, even the most competent among us is likely to become bewildered.

Understanding Troubled Minds provides a calm and authoritative guide to the full range of specific mental illnesses and available treatments. It deals with particular patterns of illness in women, children, and the elderly. It stresses the value of partnership among psychiatrists, patients, and their families. And it places this knowledge within the framework of modern psychiatry-from the history of the profession to just what it is that psychiatrists and fellow health-workers do, and how they can help.

A sense of hope and optimism prevails within these pages. The authors, both eminent psychiatrists with long practical experience, stress that great strides are being made in the treatment of mental illness. But they also warn against the lure of the instant cure. Acknowledging the complexity of human nature, they weave the stories of real people and the insights of many writers throughout their text.

Balanced, up-to-date, thoroughly readable, and humanistic, this book will both increase our practical knowledge and deepen our understanding of mental illness.

Barack Obama's foreign policy has failed but the American strategic mind has not yet closed. In After Obama, Robert Singh examines how and why US influence has weakened and contributed to the erosion of the world America made, endangering international order and liberal values. A well-intentioned but naive strategy of engagement has encouraged US adversaries such as Russia, China and Iran to assert themselves while allowing Western alliances to fray. But, challenging claims of an inevitable American decline, Singh argues that US leadership is a matter of will as much as wallet. Despite partisan polarization at home and the rise of the rest abroad, Washington can renew American leadership and, through a New American Internationalism, pave a path to the restoration of global order. Timely and provocative, the book offers a powerful critique of the Obama Doctrine and a call for strategic resolution in place of 'leading from behind'.

Molecular Methods in Plant Pathology covers methods in phytopathology at the molecular level, including PCR techniques, electron microscopy, tissue culturing, and the cloning of disease-resistant genes. Phytopathologists, botanists, horticulturists, and anyone working in agriculture will find this a useful reference on biophysical, biochemical, biomolecular, and biotechnological methods.

New Mega Trends predicts the ten trends that will make the greatest impact to business - and our lives - in the future and offers practical advice on how to profit from them
Based upon extensive research by one of the world's largest market research companies and tested with some of the largest Fortune 100 companies, New Mega Trends identifies the ten most important global trends that will redefine our world by 2020:
E-mobility
Urbanization
Health, wellness and well-being
Social trends
New battlefields
Virtual connected world
Innovating to zero
Value for money business models
Smart is the new Green
From planes to trains
Looking at each of these trends in depth, Singh not only identifies and evaluates the emerging trends, but also translates these into opportunities for everyday business and personal life.
New Mega Trends offers a vivid picture of how our working and personal lives will be changed in the years to come, and with an understanding of immediate opportunities and threats to everyday business and personal life.

No one reacts or responds to a drug in exactly the same way, just as no two persons are exactly alike. Individual and ethnic differences in drug response have been consistently found in clinical practice. This book covers all the important factors that explain how and why drug treatments used in psychiatry affect individuals and ethnic groups differently. It will increase understanding of how biological differences interact with social, cultural and environmental factors to bring about overall effects of medications, particularly in individuals from various ethnicities. This book uniquely brings these varied aspects together to consider a holistic approach to drug therapy across diverse biological make-up and cultures. This information has direct practical use in the clinical setting.

This 2004 collection of essays deals with the foundation and historical development of population biology and its relationship to population genetics and population ecology on the one hand and to the rapidly growing fields of molecular quantitative genetics, genomics and bioinformatics on the other. Such an interdisciplinary treatment of population biology has never been attempted before. The volume is set in a historical context, but it has an up-to-date coverage of material in various related fields. The areas covered are the foundation of population biology, life history evolution and demography, density and frequency dependent selection, recent advances in quantitative genetics and bioinformatics, evolutionary case history of model organisms focusing on polymorphisms and selection, mating system evolution and evolution in the hybrid zones, and applied population biology including conservation, infectious diseases and human diversity. This is the third of three volumes published in honour of Richard Lewontin.

YOUR GUIDE TO A FULFILLING BUSINESS AND PERSONAL FUTURE Based on research by one of the world's largest growth-consulting companies, New Mega Trends identifies the ten most important global trends that will define our future, including business models, smart technology, connectivity and convergence and radical social trends. New Mega Trends will give you the tools to not only identify and evaluate these game-changing trends, but also help you to translate them into market opportunities for your everyday business and personal life. How will we travel to work in the cities of the future? Will Zero be the new big thing? How will we stay connected in the Mega Trends World? Will our Wellness and Well-Being top business agenda? If you are a leader with a corporate vision, or a strategic planner within your organization, or just plain curious about your future, New Mega Trends will provide you with stimulating stories, startling facts and thought-provoking case studies that will not only inform your future but entertain you today.

Richard Lewontin is undoubtedly one of the most distinguished evolutionary biologists of our time. He has contributed to science not only by his own work on evolutionary theory and molecular variation and by his influence on the many young scientists who have worked with him but also by asking us to think about the relationships between the science we do and that world we do it in. Sciences in general, and the life sciences in particular, need their own critic, and Lewontin has been an untiring critic of science and its relevance to society. This collection of essays, first published in 2000, was produced in honour of Lewontin's 65th birthday. The volume has a comprehensive coverage of modern evolutionary genetics from molecules to morphology by a group of star authors, including his students and colleagues. The areas covered are: the mathematical and molecular foundations of population genetics, molecular variation and evolution, selection and genetic polymorphisms, linkage and breeding system evolution, quantitative genetics and phenotypic evolution, gene flow and population structure, speciation, behaviour, and ecology. The volume brings out the central role of evolutionary genetics in all aspects of its connection to evolutionary biology and is a must for all graduate students and researchers in evolutionary biology.

This collection of essays considers the foundation and historical development of population biology and its relationship to population genetics and population ecology. It also considers its relationship to the rapidly growing fields of molecular quantitative genetics, genomics and bioinformatics. Although set in historical context, the volume's up-to-date coverage of relevant material reveals the central role of population biology in all aspects of its connection to population genetics and population ecology.

Constitutional reform is a topic of perennial academic debate, perhaps now more than ever amid sharp polarization in the electorate and government. At once a cogent, new contribution to the scholarly literature and appropriate for American politics and government students, this book mounts a provocative, nonideological defense of the US Constitution, directly engaging proposals for reform and providing a rare systematic argument for continuity: Our politics may be broken but our system is not. Writing from an international perspective with an array of fascinating data, the author draws on theory, law, and history to defend the republican order under political stress and intellectual challenge.

This book highlights current business practices in the emerging markets of China, Ghana, India, Kenya, Nigeria and UAE, and explains how global competition has created a culture of competitiveness and an era of consumerism. The region-specific issues, tested theories, and empirical evidence make the book of value to both researchers and managers.

Constitutional reform is a topic of perennial academic debate, perhaps now more than ever amid sharp polarization in the electorate and government. At once a cogent, new contribution to the scholarly literature and appropriate for American politics and government students, this book mounts a provocative, nonideological defense of the US Constitution, directly engaging proposals for reform and providing a rare systematic argument for continuity: Our politics may be broken but our system is not. Writing from an international perspective with an array of fascinating data, the author draws on theory, law, and history to defend the republican order under political stress and intellectual challenge.

ETHYLENE IN PLANT BIOLOGY Comprehensive resource detailing the role of ethylene in plant development regulation, gene regulation, root development, stress tolerance, and more Ethylene in Plant Biology presents ethylene research from leading laboratories around the globe to allow readers to gain strong foundational coverage of the topic and aid in further ethylene research as it pertains to plant biology. The work covers general ideas as well as more specific and technical knowledge, detailing the overall role of ethylene in plant biology as a gaseous plant hormone that has emerged as an important signaling molecule which regulates several steps of a plant's life cycle. The ideas covered in the work range from discovery of ethylene, to its wide roles in plant growth and development, all the way to niche topics such as stress acclimation. Written by highly qualified authors in fields directly related to plant biology and research, the work is divided into 20 chapters, with each chapter covering a specific facet of ethylene or the interaction between ethylene and plant health. Topics discussed in the text include: Our current understanding of ethylene and fruit ripening, plus the role of ethylene in flower and fruit development Ethylene implications in root development and crosstalk of ethylene with other phytohormones in plant development Ethylene as a multitasking regulator of abscission processes and powerful coordinator of drought responses Mechanisms for ethylene synthesis and homeostasis in plants, along with ethylene and phytohormone crosstalk in plant defense Ethylene and metabolic reprogramming under abiotic stresses, as well as ethylene's applications in crop improvement For biologists, scientists, researchers, and policy makers in the agriculture and pharmaceutical industries, Ethylene in Plant Biology is a key resource to understand the state of the art in the field and establish a foundation of knowledge that can power future research efforts and practical applications.

Is there a gene for autism? Despite a billion-dollar, twenty-year effort to find out-and the more elusive the answer, the greater the search seems to become-no single autism gene has been identified. In Multiple Autisms, Jennifer S. Singh sets out to discover how autism emerged as a genetic disorder and how this affects those who study autism and those who live with it. This is the first sustained analysis of the practices, politics, and meaning of autism genetics from a scientific, cultural, and social perspective. In 2004, when Singh began her research, the prevalence of autism was reported as 1 in 150 children. Ten years later, the number had jumped to 1 in 100, with the disorder five times more common in boys than in girls. Meanwhile the diagnosis changed to "autistic spectrum disorders," and investigations began to focus more on genomics than genetics, less on single genes than on hundreds of interacting genes. Multiple Autisms charts this shift and its consequences through nine years of ethnographic observations, analysis of scientific and related literatures, and morethan seventy interviews with autism scientists, parents of children with autism, and people on the autism spectrum. The book maps out the social history of parental activism in autism genetics, the scientific optimism about finding a gene for autism and the subsequent failure, and the cost in personal and social terms of viewing and translating autism through a genomic lens. How is genetic information useful to people living with autism? By considering this question alongside the scientific and social issues that autism research raises, Singh's work shows us the true reach and implications of a genomic gaze.

This is the second of two volumes published by Cambridge University Press in honor of Richard Lewontin. The first volume, Evolutionary Genetics from Molecules to Morphology, honors Lewontin's more technical contributions to genetics and evolutionary biology. This second volume of essays honors the philosophical, historical, and political dimensions of his work. Given the range of Lewontin's own contributions, it is fitting that the volume covers such a wide range of perspectives on modern biology. He was a very successful practitioner of evolutionary genetics, a rigorous critic of the practices of genetics and evolutionary biology, as well as an articulate analyst of the social, political, and economic contexts and consequences of genetic and evolutionary research. The volume contains an essay by Lewontin on Natural History and Formalism in Evolutionary Genetics, and an extended interview with Lewontin, covering the history of evolutionary genetics as seen from his perspective and exemplified by his career. The remaining chapters, contributed by former students, post-docs, colleagues, and collaborators, cover issues ranging from the history and conceptual foundations of evolutionary biology and genetics, to the implications of human genetic diversity, to the political economy of agriculture and public health.

No one reacts or responds to a drug in exactly the same way, just as no two persons are exactly alike. Individual and ethnic differences in drug response have been consistently found in clinical practice. This book covers all the important factors that explain how and why drug treatments used in psychiatry affect individuals and ethnic groups differently. It will increase understanding of how biological differences interact with social, cultural and environmental factors to bring about overall effects of medications, particularly in individuals from various ethnicities. This book uniquely brings these varied aspects together to consider a holistic approach to drug therapy across diverse biological make-up and cultures. This information has direct practical use in the clinical setting.

Lewontin is undoubtedly one of the most distinguished evolutionary biologists of our time. He has contributed to science not only by his own work on evolutionary theory and molecular variation and by his influence on the many young scientists who have worked with him, but also by asking us to think about the relationships between the science we do and the world we do it in. This collection of essays is produced in honor of Lewontin's 65th birthday. This unique volume offers comprehensive coverage of modern evolutionary genetics from molecules to morphology by a group of star authors, including his students and colleagues. Sciences in general, and the life sciences in particular, need their own critic, and Lewontin has been an untiring critic of science and its relevance to society. This volume brings out the central role of evolutionary genetics in all aspects of its connection to evolutionary biology and is a must for all graduate students and researchers in evolutionary biology.