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Prepared by world leaders on this topic, Biomarkers in Cancer
Screening and Early Detection offers a comprehensive,
state-of-the-art perspective on the various research and clinical
aspects of cancer biomarkers, from their discovery and development
to their validation, clinical utility, and use in developing
personalized cancer treatment. * Offers a comprehensive,
state-of-the-art perspective on the various research and clinical
aspects of cancer biomarkers * Provides immediately actionable
information and hopefully also inspiration to move discovery and
clinical application forward * Offers vital knowledge to help
develop personalized cancer treatment for individual patients with
specific cancers
The genesis of the volume, Plant Biotechnology and Molecular
Markers, has been the occasion of the retirement of Professor Sant
Saran Bhojwani from the Department of Botany, University of Delhi.
For Professor Bhojwani, retirement only means relinquishing the
chair as being a researcher and a teacher which has always been a
way of life to him. Professor Bhojwani has been an ardent
practitioner of modern plant biology and areas like Plant
Biotechnology and Molecular Breeding have been close to his heart.
The book contains original as well as review articles contributed
by his admirers and associates who are experts in their area of
research. While planning this contributory book our endeavour has
been to incorporate articles that cover the entire gamut of Plant
Biotechnology, and also applications of Molecular Markers. Besides
articles on in vitro fertilization and micropropagation, there are
articles on forest tree improvement through genetic engineering.
Considering the importance of conservation of our precious natural
wealth, one article deals with cryopreservation of plant material.
Chapter on molecular marker considers DNA indexing as markers of
clonal fidelity of in vitro regenerated plants and prevention
against bio-piracy. A couple of write-ups also cover stage-specific
gene markers, DNA polymorphism and genetic engineering, including
raising of stress tolerant plants to sustain productivity and help
in reclamation of degraded land.
The volumes of this classic series, now referred to simply as
"Zechmeister" after its founder, L. Zechmeister, have appeared
under the Springer Imprint ever since the series' inauguration in
1938. The volumes contain contributions on various topics related
to the origin, distribution, chemistry, synthesis, biochemistry,
function or use of various classes of naturally occurring
substances ranging from small molecules to biopolymers. Each
contribution is written by a recognized authority in his field and
provides a comprehensive and up-to-date review of the topic in
question. Addressed to biologists, technologists, and chemists
alike, the series can be used by the expert as a source of
information and literature citations and by the non-expert as a
means of orientation in a rapidly developing discipline.
The discipline of microbiology that deals with an amazingly diverse
group of simple organisms, such as viruses, archaea, bacteria,
algae, fungi, and protozoa, is an exciting field of Science.
Starting as a purely descriptive field, it has transformed into a
truly experimental and interdisciplinary science inspiring a number
of investigators to generate th a wealth of information on the
entire gamut of microbiology. The later part of 20 century has been
a golden era with molecular information coming in to unravel
interesting insights ofthe microbial world. Ever since they were
brought to light through a pair of ground glasses by the Dutchman,
Antony van Leeuwenhoek, in later half of 17th century, they have
been studied most extensively throughout the next three centuries,
and are still revealing new facets of life and its functions. The
interest in them, therefore, continues even in the 21 st century.
Though they are simple, they provide a wealth of information on
cell biology, physiology, biochemistry, ecology, and genetics and
biotechnology. They, thus, constitute a model system to study a
whole variety of subjects. All this provided the necessary impetus
to write several valuable books on the subject of microbiology.
While teaching a course of Microbial Genetics for the last 35 years
at Delhi University, we strongly felt the need for authentic
compiled data that could give exhaustive background information on
each of the member groups that constitute the microbial world.
Control of polymeric structure is among the most important
endeavours of modern macromolecular science. In particular,
tailoring the positioning and strength of intermolecular forces
within macromolecules by synthetic me- odsandthusgaining
structuralcontrolover the?nalpolymeric materials has become
feasible, resulting in the ?eld of supramolecular polymer science.
- sides other intermolecular forces, hydrogen bonds are unique
intermolecular forces enabling the tuning of material properties
via self-assembly processes -1
overawiderangeofinteractionstrengthrangingfromseveralkJmol tosev-
-1 eraltensofkJmol .
Centralfortheformationofthesestructuresareprecursor molecules of
small molecular weight (usually lower than 10 000), which can
assembleinsolidorsolutiontoaggregatesofde?nedgeometry.
Intermolecular
hydrogenbondsatde?nedpositionsofthesebuildingblocksaswellastheir-
spectivestartinggeometryandtheinitialsizedeterminethemodeofassembly
into supramolecular polymers forming network-, rodlike-, ?brous-,
disclike- , helical-, lamellar- and chainlike architectures. In all
cases, weak to strong
hydrogen-bondinginteractionscanactasthecentralstructure-directingforce
fortheorganizationofpolymerchainsandthusthe?nalmaterials'properties.
Theimportantcontributionofhydrogenbondstotheareaofsupramole- lar
polymer chemistry is de?nitely outstanding, most of all since the
potency of hydrogen-bonding systems has been found to be unique in
relation to other supramolecular interactions. Thus the high level
of structural diversity of many hydrogen-bonding systems as well as
their high level of direction- ity and speci?city in
recognition-phenomena is unbeaten in supramolecular chemistry. The
realization, that their stability can be tuned over a wide range of
binding strength is important for tuning the resulting material
prop- ties, ranging from elastomeric to thermoplastic and even
highly crosslinked duroplastic structures and networks. On the
basis of the thermal reversib- ity, new materials with highly
tunable properties can now be prepared, - ing able to change their
mechanical and optoelectronic properties with very
smallchangesofexternalstimuli. Thusthe?eldofhydrogen-bondedpolymers
forms the basis for stimuli responsive and adaptable materials of
the future.
Bacteria occupy a unique position in the living world. They are
amongst the first inhabitants of planet earth, and have survived
until the present day. Adaptation, adjustment, and accommodation
are the hallmarks of their strategy for survival. Their structural
simplicity, and yet independent lifestyle, has provided a baseline
model system on which every branch of modern biology have been
founded. This includes the fields of molecular genetics and
recombinant DNA technology. Bacteria have been at the heart of
developments in the field of biotechnology where today many
microbial and eukaryotic (including human) metabolites have found
industrial applications. Amenable to all modern tools and
techniques, bacteriology has developed an interface with all other
branches of biology, often providing the major leads and clues. In
the present era of genomics, now that many microbial genomes have
been sequenced, bacteria are destined to provide new information
that will further our understanding of life and biological
processes.
This book contains exhaustive information on almost all aspects of
bacteria. The book deals exclusively with bacteria and includes the
entire gamut of bacteriology. It will be useful to graduate and
post-graduate levels but also to established researchers. The book
is organized in such a way that it will give the reader an overview
of our current understanding of bacteria. It will explain the
categories under which various types have been grouped and describe
the versatile range of metabolic processes which can be found in
these microbial organisms. Their metabolic regulation, capacity to
change and keep evolving and their pivotal role in natural
processes arehighlighted. Research on bacteria, especially genetic
engineering, will have far reaching applications in the future.
The volumes of this classic series, now referred to simply as
"Zechmeister" after its founder, L. Zechmeister, have appeared
under the Springer Imprint ever since the series' inauguration in
1938. The volumes contain contributions on various topics related
to the origin, distribution, chemistry, synthesis, biochemistry,
function or use of various classes of naturally occurring
substances ranging from small molecules to biopolymers. Each
contribution is written by a recognized authority in his field and
provides a comprehensive and up-to-date review of the topic in
question. Addressed to biologists, technologists, and chemists
alike, the series can be used by the expert as a source of
information and literature citations and by the non-expert as a
means of orientation in a rapidly developing discipline.
Any method of fitting equations to data may be called regression.
Such equations are valuable for at least two purposes: making
predictions and judging the strength of relationships. Because they
provide a way of em pirically identifying how a variable is
affected by other variables, regression methods have become
essential in a wide range of fields, including the soeial seiences,
engineering, medical research and business. Of the various methods
of performing regression, least squares is the most widely used. In
fact, linear least squares regression is by far the most widely
used of any statistical technique. Although nonlinear least squares
is covered in an appendix, this book is mainly ab out linear least
squares applied to fit a single equation (as opposed to a system of
equations). The writing of this book started in 1982. Since then,
various drafts have been used at the University of Toronto for
teaching a semester-Iong course to juniors, seniors and graduate
students in a number of fields, including statistics, pharmacology,
pharmacology, engineering, economics, forestry and the behav ioral
seiences. Parts of the book have also been used in a quarter-Iong
course given to Master's and Ph.D. students in public
administration, urban plan ning and engineering at the University
of Illinois at Chicago (UIC). This experience and the comments and
critieisms from students helped forge the final version."
Some novel schiff bases of 3-aminomethyl pyridine and 2-amino
pyridine have been synthesized through condensation reaction with
substituted aryl aldehydes/ketones and/alicyclic ketones. These
schiff bases were screened for anticonvulsant activity,
neurotoxicity and antideprassant activity. The chemical structures
of synthesized compounds were confirmed by FT-IR, 1H-NMR, 13C-NMR
spectroscopy, and elemental analysis. In the preliminary
anticonvulsant screening, three convulsant test models were used:
maximal electro shock (MES), subcutaneous pentylenetetrazole
(sc.PTZ), subcutaneous strychnine (sc.STY) and neurotoxicity screen
(rotorod method in mice). Protective index (PI) is considered an
index of the margin of safety and tolerability between
anticonvulsant doses and doses of various synthesized compounds
exerting acute adverse effects. In Phase-II screening in mice ED50
and TD50 and PI were determined. Some selected compounds were
subjected to oral MES screen in rats and were found effective
against MES test.
COMPARATIVE EMBRYOLOGY OF ANGIOSPERMS is a review of the
developmental processes leading to sexual reproduction in flowering
plants. On the basis of embryological data and certain evidences
from other areas of study, it lays special emphasis on the
relationship among and within the families and orders of
angiosperms. Occasionally, inaccuracies in observation and
interpretation are pointed out, alternative interpretations
offered, gaps in our knowledge highlighted, and prospects outlined.
The text is documented with 36 tables, 376 figures, and about 5000
literature citations, which contribute to making this book
comprehensive. Besides students and research workers interested in
angiosperm embyology, taxonomists, plant breeders, agriculturists,
and horticulturists will also find much useful information in this
treatise.
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