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This second of the three-volume tuberculosis book series provides a
comprehensive overview of immunological and cell biological aspects
of tuberculosis. Edited by the undisputed world leader in the
field, this is the most comprehensive book on the topic available,
and the first in recent years to focus on both basic research and
clinical aspects of TB.
The immune deficiency AIDS leads to a drastic increase in
susceptibility to Tuberculosis. Accordingly, co-infections of
tuberculosis (TB) and AIDS have increased dramatically over the
last decades and have already killed more than 5 million people
worldwide. Currently, no vaccines are available for either of these
diseases leaving doctors with limited options for prevention. This
perfect storm of pandemics is analysed and explained for the first
time in this groundbreaking title, edited by two of the most
accomplished experts in this area, Prof. Dr. Dr. h.c. Stefan
Kaufmann at the Max-Planck Institute for infectious diseases in
Berlin, Germany, and Prof. Dr. Bruce Walker, director of the Ragon
Institute of MGH, MIT and Harvard in Boston, USA. Co-infection of
AIDS and TB occur frequently in the most impoverished regions of
the world and the AIDS pandemic which has spread rapidly across
Africa over the past two decades is now being met by a TB pandemic.
While TB can be cured and AIDS can be treated, co-infection in a
single patient presents unique challenges and the rapid expansion
of these two pandemics has resulted in a critical need to better
understand the interactions between the two pathogens and to
integrate research efforts. This title brings together scientists
from the forefront of research to explore and combine
state-of-the-art studies in drug interactions and disease
therapies, providing the latest information about prevention,
therapy and diagnosis of both tuberculosis and AIDS. This is the
only book to place a clear emphasis on the increasing number of
patients suffering from both tuberculosis and AIDS and is unique in
combining expertise from both fields. Using a multi-disciplinary
approach the authors bring together the issues surrounding
treatment of co-infection by highlighting the problems of treatment
overlap and providing new data demonstrating exactly how this
deadly liaison plays out. Early chapters focus on immunology and
the problems facing vaccination strategies for both diseases.
Currently no vaccines exist for either disease and the coexistence
of both pathogens in a single patient complicates the research for
new preventive, diagnostic or therapeutic approaches. Later
chapters deal with some of the most threatening consequences of
this co-infection, such as the emergence of drug resistant TB.
These chapters also deal with the need to simultaneously treat both
infections, highlighting the major problem of drug interaction if
two treatments which have been researched in isolation are given to
one individual. Together the contributing authors offer a
refreshingly new and engaging analysis of this most challenging of
topics and offer new therapeutic approaches by providing
comprehensive understanding of both diseases. This title is of
strong interest to a broad range of research communities, from
microbiologists and virologists to immunologists and medical
doctors specializing in TB and AIDS treatment as well as to the
pharmaceutical and biotechnological Industries. Aids and
Tuberculosis: A Deadly Liaison is the first title in
Wiley-Blackwell's 'Infection Biology Handbook Series'. The second
title in the series is Bacterial Virulence: Basic Principles,
Models and Global Approaches , edited by Philippe Sansonetti from
the Pasteur Institute in Paris, France.
Tuberculosis (TB), a deadly airborne disease caused by the
bacterium Mycobacterium tuberculosis, takes the lives of almost 2
million people each year and is considered to be the most common
infectious disease in the world. However, thanks to the efforts of
researchers such as the volumes' lead editor, Dr. Stefan H. E.
Kaufmann, there have been several recent advances in fighting the
disease. Dr. Stefan Kaufmann, the Founding Director of the Max
Planck Institute for Infection Biology in Berlin and Professor of
Microbiology and Immunology at the Charite at the Humboldt
University, Berlin, has published more than 600 scientific articles
and currently serves as President of the European Federation of
Immunological Societies and Chair of the Immunology Division of the
American Society of Microbiology. Dr. Kaufmann is considered the
world's leading expert in the field of tuberculosis. The Handbook
of Tuberculosis, which explores the causes and available treatments
of the widespread infection as well as current research into
vaccination, is divided into three separate volumes covering
different areas of study. Each volume provides an essential
resource to molecular and cell biologists, bacteriologists,
immunologists, pathologists and pathophysiologists, clinicians and
those working in the pharmaceutical industry and interested in
world health. Volume 1: Molecular Biology and Biochemistry
highlights the molecular mechanisms of tuberculosis. Volume 2:
Immunology and Cell Biology presents the pre-eminent resource for
all aspects of cell biology and immunology of tuberculosis,
including vaccine development. Volume 3: Clinics, Diagnostics,
Therapy and Epidemiology introduces a comprehensive overview of
clinical aspects of tuberculosis, including drug resistance,
epidemiological aspects and clinical trials. It is co-edited by Dr.
Paul van Helden, Professor of Medical Biochemistry at Stellenbosch
University, South Africa, Director of Laboratory Research for the
Desmond Tutu Tuberculosis Centre and former President of the South
African Society of Biochemistry and Molecular Biology.
This first of the three-volume tuberculosis book series provides a
comprehensive overview of molecular biological and biochemical
aspects of tuberculosis. Edited by the undisputed world leader in
the field, this is the most comprehensive book on the topic
available, and the first in recent years to focus on both basic
research and clinical aspects of TB.
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