This second of the three-volume tuberculosis book series provides a comprehensive overview of immunological and cell biological aspects of tuberculosis. Edited by the undisputed world leader in the field, this is the most comprehensive book on the topic available, and the first in recent years to focus on both basic research and clinical aspects of TB.

The immune deficiency AIDS leads to a drastic increase in susceptibility to Tuberculosis. Accordingly, co-infections of tuberculosis (TB) and AIDS have increased dramatically over the last decades and have already killed more than 5 million people worldwide. Currently, no vaccines are available for either of these diseases leaving doctors with limited options for prevention. This perfect storm of pandemics is analysed and explained for the first time in this groundbreaking title, edited by two of the most accomplished experts in this area, Prof. Dr. Dr. h.c. Stefan Kaufmann at the Max-Planck Institute for infectious diseases in Berlin, Germany, and Prof. Dr. Bruce Walker, director of the Ragon Institute of MGH, MIT and Harvard in Boston, USA. Co-infection of AIDS and TB occur frequently in the most impoverished regions of the world and the AIDS pandemic which has spread rapidly across Africa over the past two decades is now being met by a TB pandemic. While TB can be cured and AIDS can be treated, co-infection in a single patient presents unique challenges and the rapid expansion of these two pandemics has resulted in a critical need to better understand the interactions between the two pathogens and to integrate research efforts. This title brings together scientists from the forefront of research to explore and combine state-of-the-art studies in drug interactions and disease therapies, providing the latest information about prevention, therapy and diagnosis of both tuberculosis and AIDS. This is the only book to place a clear emphasis on the increasing number of patients suffering from both tuberculosis and AIDS and is unique in combining expertise from both fields. Using a multi-disciplinary approach the authors bring together the issues surrounding treatment of co-infection by highlighting the problems of treatment overlap and providing new data demonstrating exactly how this deadly liaison plays out. Early chapters focus on immunology and the problems facing vaccination strategies for both diseases. Currently no vaccines exist for either disease and the coexistence of both pathogens in a single patient complicates the research for new preventive, diagnostic or therapeutic approaches. Later chapters deal with some of the most threatening consequences of this co-infection, such as the emergence of drug resistant TB. These chapters also deal with the need to simultaneously treat both infections, highlighting the major problem of drug interaction if two treatments which have been researched in isolation are given to one individual. Together the contributing authors offer a refreshingly new and engaging analysis of this most challenging of topics and offer new therapeutic approaches by providing comprehensive understanding of both diseases. This title is of strong interest to a broad range of research communities, from microbiologists and virologists to immunologists and medical doctors specializing in TB and AIDS treatment as well as to the pharmaceutical and biotechnological Industries. Aids and Tuberculosis: A Deadly Liaison is the first title in Wiley-Blackwell's 'Infection Biology Handbook Series'. The second title in the series is Bacterial Virulence: Basic Principles, Models and Global Approaches , edited by Philippe Sansonetti from the Pasteur Institute in Paris, France.

Tuberculosis (TB), a deadly airborne disease caused by the bacterium Mycobacterium tuberculosis, takes the lives of almost 2 million people each year and is considered to be the most common infectious disease in the world. However, thanks to the efforts of researchers such as the volumes' lead editor, Dr. Stefan H. E. Kaufmann, there have been several recent advances in fighting the disease. Dr. Stefan Kaufmann, the Founding Director of the Max Planck Institute for Infection Biology in Berlin and Professor of Microbiology and Immunology at the Charite at the Humboldt University, Berlin, has published more than 600 scientific articles and currently serves as President of the European Federation of Immunological Societies and Chair of the Immunology Division of the American Society of Microbiology. Dr. Kaufmann is considered the world's leading expert in the field of tuberculosis. The Handbook of Tuberculosis, which explores the causes and available treatments of the widespread infection as well as current research into vaccination, is divided into three separate volumes covering different areas of study. Each volume provides an essential resource to molecular and cell biologists, bacteriologists, immunologists, pathologists and pathophysiologists, clinicians and those working in the pharmaceutical industry and interested in world health. Volume 1: Molecular Biology and Biochemistry highlights the molecular mechanisms of tuberculosis. Volume 2: Immunology and Cell Biology presents the pre-eminent resource for all aspects of cell biology and immunology of tuberculosis, including vaccine development. Volume 3: Clinics, Diagnostics, Therapy and Epidemiology introduces a comprehensive overview of clinical aspects of tuberculosis, including drug resistance, epidemiological aspects and clinical trials. It is co-edited by Dr. Paul van Helden, Professor of Medical Biochemistry at Stellenbosch University, South Africa, Director of Laboratory Research for the Desmond Tutu Tuberculosis Centre and former President of the South African Society of Biochemistry and Molecular Biology.

This first of the three-volume tuberculosis book series provides a comprehensive overview of molecular biological and biochemical aspects of tuberculosis. Edited by the undisputed world leader in the field, this is the most comprehensive book on the topic available, and the first in recent years to focus on both basic research and clinical aspects of TB.