This issue of Emergency Medicine Clinics, guest edited by Drs. Gentry Wilkerson, Sal J. Suau, focuses on Allergy, Inflammatory, and Autoimmune Disorders in Emergency Medicine. This issue is one of four selected each year by series Consulting Editor, Dr. Amal Mattu. Topics include: Allergy/Anaphylaxis, Anaphylaxis: Treatment in the ED, Drug Allergies, Food Allergies, Allergic acute coronary syndrome - Kounis Syndrome; Hereditary and Acquired Angioedema, Immunotherapy, Sarcoidosis, Spondyloarthritides and Autoimmune Connective Tissue Diseases.