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Diabetes occurs at such an alarming rate that it can be described
as a global epidemic. Following its predecessor, Nutrition and
Diabetes: Pathophysiology and Management, Second Edition, is a
comprehensive resource that describes various factors that drive
the accumulation of excess body weight and fat resulting in
obesity. The book discusses the metabolic aberrations found in
obesity and how they lead to the association of obesity with
diabetes. This new edition highlights the role played by diet and
the interrelationships in the metabolism of key nutrients in the
pathogenesis of obesity and diabetes which provides the scientific
basis for treatment and management approaches. Features Highlights
the role of nutrition in the pathogenesis of obesity and diabetes
Organized logically into two easy-to-use sections - Pathophysiology
and Management of Obesity and Pathophysiology and Treatment of
Diabetes Features emerging therapeutic approaches for management of
obesity and diabetes Discusses experience in the management of
obesity and diabetes in developing countries Presents challenges in
insulin therapy and provides guidelines to overcome them The first
section of the book retains key topics from the previous edition
and contains new chapters including genetic determinants of
nutrient processing; fat distribution and diabetes mellitus;
combined effect of diet and physical activity in the management of
obesity; pharmacologic treatment of obesity; and the role of gut
microbiota in the pathogenesis and treatment of obesity. The second
section features updated versions of most of the other chapters in
the first edition comprising a modified chapter on oxidative stress
and the effects of dietary supplements on glycemic control in Type
2 diabetes. In addition, new chapters are added in this section and
include the contribution of iron and transition metal
micronutrients to diabetes; role of microbiota in the pathogenesis
and treatment of diabetes; primary prevention of Type 2 diabetes;
and the pathophysiology and management of Type 1 diabetes.
Twenty years after its discovery, recombinant human leptin has been
approved by the Food and Drug Administration for the treatment of
patients with lipodystrophy. Beginning with a synthesis of the vast
body of work on its discovery, dissection of mechanisms, and
effects in experimental models , the focus of this book shifts to a
consideration of the regulation and role of leptin in humans. The
emphasis on human-level data is a unique feature of this book. The
results of numerous studies indicate that leptin is indeed a
regulated human hormone. Leptin provides a detailed account of the
myriad physiological, hormonal, metabolic, immunological, mitogenic
and inflammatory modulators and targets of leptin in a single
volume. Next follows a comprehensive presentation of the
therapeutic trials of recombinant leptin in patients with
congenital leptin deficiency, lipodystrophy, hypothalamic
amenorrhea, and other emerging areas, including leptin
supplementation in leptin-replete subjects, leptin substitution for
insulin in diabetic models, and novel combination regimens of
leptin and other biogenic peptides. Unanswered questions and future
directions in leptin research are highlighted in the Foreword by
Dr. Jeffrey Friedman and throughout the volume. Identifying such
questions helps direct research that could deepen understanding of
the complex regulation of leptin under physiological and
pathological conditions, a critical prerequisite to its rational
deployment in the treatment of human disorders.
Twenty years after its discovery, recombinant human leptin has been
approved by the Food and Drug Administration for the treatment of
patients with lipodystrophy. Beginning with a synthesis of the vast
body of work on its discovery, dissection of mechanisms, and
effects in experimental models , the focus of this book shifts to a
consideration of the regulation and role of leptin in humans. The
emphasis on human-level data is a unique feature of this book. The
results of numerous studies indicate that leptin is indeed a
regulated human hormone. Leptin provides a detailed account of the
myriad physiological, hormonal, metabolic, immunological, mitogenic
and inflammatory modulators and targets of leptin in a single
volume. Next follows a comprehensive presentation of the
therapeutic trials of recombinant leptin in patients with
congenital leptin deficiency, lipodystrophy, hypothalamic
amenorrhea, and other emerging areas, including leptin
supplementation in leptin-replete subjects, leptin substitution for
insulin in diabetic models, and novel combination regimens of
leptin and other biogenic peptides. Unanswered questions and future
directions in leptin research are highlighted in the Foreword by
Dr. Jeffrey Friedman and throughout the volume. Identifying such
questions helps direct research that could deepen understanding of
the complex regulation of leptin under physiological and
pathological conditions, a critical prerequisite to its rational
deployment in the treatment of human disorders.
Diabetes Guide adopts a novel "non-textual" approach to the
dissemination ofcomprehensive, up-to-date information on the theory
and practice of diabetology. This has been achieved through the
liberal use of tables, diagrams, flowsheets, summaries and
annotations in place of the usual prose and verbiage. As a result
of such an economic use of space, vast amounts of knowledge on the
definition, classification, management complications and various
other aspects of diabetes have been condensed intoa surprisingly
digestible pocketbook. Emerging perspectives on genetic counseling,
the insulin gene and pancreatic transplantation are also
incorporated. One outstanding feature of Diabetes Guide is the
provision of succinct practical recommendations for the solution of
problemsthat arise during the daily care of patients with diabetes.
The subjects covered under these recommendations range from insulin
infuser pump problems, care of foot ulcers, food exchanges, travel
and acute illness, insulin allergy and desensitization protocol,
diabetic emergencies, pregnancy, surgery, hypoglycaemia, etc. Such
breadth of coverage has been achieved without the usual price of
increased bulk through the unique "non-Textual" approach. Diabetes
Guide is designed to be a user-friendly, ready reference of vade
mecum for practical tips and core information on various aspects of
diabetes.
Diabetes occurs at such an alarming rate that it can be described
as a global epidemic. Following its predecessor, Nutrition and
Diabetes: Pathophysiology and Management, Second Edition, is a
comprehensive resource that describes various factors that drive
the accumulation of excess body weight and fat resulting in
obesity. The book discusses the metabolic aberrations found in
obesity and how they lead to the association of obesity with
diabetes. This new edition highlights the role played by diet and
the interrelationships in the metabolism of key nutrients in the
pathogenesis of obesity and diabetes which provides the scientific
basis for treatment and management approaches. Features Highlights
the role of nutrition in the pathogenesis of obesity and diabetes
Organized logically into two easy-to-use sections - Pathophysiology
and Management of Obesity and Pathophysiology and Treatment of
Diabetes Features emerging therapeutic approaches for management of
obesity and diabetes Discusses experience in the management of
obesity and diabetes in developing countries Presents challenges in
insulin therapy and provides guidelines to overcome them The first
section of the book retains key topics from the previous edition
and contains new chapters including genetic determinants of
nutrient processing; fat distribution and diabetes mellitus;
combined effect of diet and physical activity in the management of
obesity; pharmacologic treatment of obesity; and the role of gut
microbiota in the pathogenesis and treatment of obesity. The second
section features updated versions of most of the other chapters in
the first edition comprising a modified chapter on oxidative stress
and the effects of dietary supplements on glycemic control in Type
2 diabetes. In addition, new chapters are added in this section and
include the contribution of iron and transition metal
micronutrients to diabetes; role of microbiota in the pathogenesis
and treatment of diabetes; primary prevention of Type 2 diabetes;
and the pathophysiology and management of Type 1 diabetes.
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