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Books > Medicine > Pre-clinical medicine: basic sciences > Physiology > Metabolism
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Leptin - Regulation and Clinical Applications (Hardcover, 2015 ed.)
Loot Price: R3,071
Discovery Miles 30 710
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Leptin - Regulation and Clinical Applications (Hardcover, 2015 ed.)
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Twenty years after its discovery, recombinant human leptin has been
approved by the Food and Drug Administration for the treatment of
patients with lipodystrophy. Beginning with a synthesis of the vast
body of work on its discovery, dissection of mechanisms, and
effects in experimental models , the focus of this book shifts to a
consideration of the regulation and role of leptin in humans. The
emphasis on human-level data is a unique feature of this book. The
results of numerous studies indicate that leptin is indeed a
regulated human hormone. Leptin provides a detailed account of the
myriad physiological, hormonal, metabolic, immunological, mitogenic
and inflammatory modulators and targets of leptin in a single
volume. Next follows a comprehensive presentation of the
therapeutic trials of recombinant leptin in patients with
congenital leptin deficiency, lipodystrophy, hypothalamic
amenorrhea, and other emerging areas, including leptin
supplementation in leptin-replete subjects, leptin substitution for
insulin in diabetic models, and novel combination regimens of
leptin and other biogenic peptides. Unanswered questions and future
directions in leptin research are highlighted in the Foreword by
Dr. Jeffrey Friedman and throughout the volume. Identifying such
questions helps direct research that could deepen understanding of
the complex regulation of leptin under physiological and
pathological conditions, a critical prerequisite to its rational
deployment in the treatment of human disorders.
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