This book constitutes the refereed proceedings of the Second Southern African Conference on Artificial Intelligence Research, SACAIR 2021, held in Durban, South Africa, in December 2021. Due to the COVID-19 pandemic the SACAIR 2021 was held online. The 22 papers presented were thoroughly reviewed and selected from the 70 submissions. They are organized on the topical sections on AI in the humanities and society, AI in and for information systems, computer vision and image processing, deep learning, knowledge representation and reasoning, machine learning, philosophy and ethics of AI.