This book covers the Phytochemical investigation and evaluation of hypolipidemic activity of Melothria maderaspatana (Linn) in high fat diet fed rats. Melothria maderaspatana is a plant drug belonging to family cucurbitaceae, mostly prevalent in south India. Melothria is a large genus of herbs with 105 species found in warmer region of world. Melothria maderaspatana Linn, is a high valued medicinal significance. It aimed to isolate phytoconstituents and then to characterized them by various methods like TLC, FT-IR, 1H-NMR, spectroscopy. Then aqueous extract of Melothria maderaspatana plant was used for the investigation of hypolipidemic activity in rats. This book will provide food of thoughts for researchers and academicians regarding the future trends and research methodologies on phytochemical investigations on plant Melothria maderaspatana (Linn).

Some novel schiff bases of 3-aminomethyl pyridine and 2-amino pyridine have been synthesized through condensation reaction with substituted aryl aldehydes/ketones and/alicyclic ketones. These schiff bases were screened for anticonvulsant activity, neurotoxicity and antideprassant activity. The chemical structures of synthesized compounds were confirmed by FT-IR, 1H-NMR, 13C-NMR spectroscopy, and elemental analysis. In the preliminary anticonvulsant screening, three convulsant test models were used: maximal electro shock (MES), subcutaneous pentylenetetrazole (sc.PTZ), subcutaneous strychnine (sc.STY) and neurotoxicity screen (rotorod method in mice). Protective index (PI) is considered an index of the margin of safety and tolerability between anticonvulsant doses and doses of various synthesized compounds exerting acute adverse effects. In Phase-II screening in mice ED50 and TD50 and PI were determined. Some selected compounds were subjected to oral MES screen in rats and were found effective against MES test.