Although there are numerous books on drug metabolism, Radiotracers in Drug Development is unique in explaining how radiotracers are used to elucidate a drug's absorption, distribution, metabolism, and excretion (ADME). Covering traditional and recent technologies and applications, the book takes a strong industrial approach, discussing the basics of scintillation counting and untangling the various data processing methods often specific to individual manufacturers. The chapters include descriptions of the latest micro-plate counters and the growing applications of accelerator mass spectrometry, positron emission tomography, gamma-scintigraphy, and radioluminography. In addition to describing how the analytical technologies work, the contributors explain how the data are interpreted and used in the drug registration process. A unique reference and training aid essential for every drug metabolism department or drug metabolism research team, the book provides insight into the use and practice of ADME in a way that is both instructive and practical. Moving easily across the boundaries of biology, chemistry, and physics, this is the only comprehensive, interdisciplinary resource covering the how-tos of employing radiotracers in drug development. It provides detailed information on how the science is relevant to the registration process.

Woza Albert! is one of the most popular and influential plays to have come out of the South African cultural struggle of the 1980s and a central work in the canon of South African theatre. Working with the idea of the Second Coming of Jesus Christ taking place in apartheid South Africa, the playwrights improvised a brilliant two-man show consisting of 26 vignettes, commenting on and satirising life under the apartheid regime. The play has become one of the most anthologized and produced South African plays both in South Africa, and internationally and is studied widely in schools as well as universities. This Student Edition contains a commentary and notes by Temple Hauptfleisch, Emeritus Professor at Stellenbosch University, South Africa. METHUEN DRAMA STUDENT EDITIONS are expertly annotated texts of a wide range of plays from the modern and classic repertoires. A well as the complete text of the play itself, this volume contains: * A contextualised chronology of the play and the playwrights' lives and works * an introductory discussion of the social, political, cultural and economic context in which the play was originally conceived and created * a succinct overview of the creation processes followed and subsequent performance history of the piece * an analysis of, and commentary on, some of the major themes and specific issues addressed by the text * a bibliography of suggested primary and secondary materials.

Although there are numerous books on drug metabolism, Radiotracers in Drug Development is unique in explaining how radiotracers are used to elucidate a drug's absorption, distribution, metabolism, and excretion (ADME). Covering traditional and recent technologies and applications, the book takes a strong industrial approach, discussing the basics of scintillation counting and untangling the various data processing methods often specific to individual manufacturers.

The chapters include descriptions of the latest micro-plate counters and the growing applications of accelerator mass spectrometry, positron emission tomography, gamma-scintigraphy, and radioluminography. In addition to describing how the analytical technologies work, the contributors explain how the data are interpreted and used in the drug registration process.

A unique reference and training aid essential for every drug metabolism department or drug metabolism research team, the book provides insight into the use andpractice of ADME in a way that is both instructive and practical. Moving easily across the boundaries of biology, chemistry, and physics, this is the only comprehensive, interdisciplinary resource covering the how-tos of employing radiotracers in drug development. It provides detailed information on how the science is relevant to the registration process.