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Radiotracers in Drug Development (Paperback)
Loot Price: R1,988
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Radiotracers in Drug Development (Paperback)
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Although there are numerous books on drug metabolism, Radiotracers
in Drug Development is unique in explaining how radiotracers are
used to elucidate a drug's absorption, distribution, metabolism,
and excretion (ADME). Covering traditional and recent technologies
and applications, the book takes a strong industrial approach,
discussing the basics of scintillation counting and untangling the
various data processing methods often specific to individual
manufacturers. The chapters include descriptions of the latest
micro-plate counters and the growing applications of accelerator
mass spectrometry, positron emission tomography,
gamma-scintigraphy, and radioluminography. In addition to
describing how the analytical technologies work, the contributors
explain how the data are interpreted and used in the drug
registration process. A unique reference and training aid essential
for every drug metabolism department or drug metabolism research
team, the book provides insight into the use and practice of ADME
in a way that is both instructive and practical. Moving easily
across the boundaries of biology, chemistry, and physics, this is
the only comprehensive, interdisciplinary resource covering the
how-tos of employing radiotracers in drug development. It provides
detailed information on how the science is relevant to the
registration process.
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