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Brucellosis is one of the most important zoonotic diseases
world-wide. This book focuses on host natural resistance and innate
immunity against Brucella infection. The impact of Johne's disease,
a chronic, granulomatous enteritis of ruminants and some wild-type
species is examined as well. In addition, the molecular and
cellular mechanisms of DNA vaccines are addressed in this book, as
well as the optimisation strategies that are currently pursued to
harness the therapeutic and commercial advantages of DNA
vaccination. Moreover, immune responses may substantially differ
between conventional laboratory antigens and microbial ones. This
book focuses on the experimental pulmonary tuberculosis as a
convenient in vivo model to study the disease, providing important
advantages over other models. Other chapters examine the defence
mechanisms of several flatfish species, which is a main priority to
prevent economic losses. The role of the intestine in the immune
response in all vertebrates is examined as well, including its
cellular components.
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