Emerging Nanotechnologies in Immunology aims to deliver a systematic and comprehensive review of data concerning the nature of interaction and nano-related risks between the nanophamaceuticals currently in the pipeline of S&T development for skin, ocular, and nasal drug delivery, including absorption, toxicity, and the ability to distribute after systemic exposure. The scientific development of manufactured nanomaterials for drug delivery is increasing rapidly. One of the most prominent applications is topical drug delivery, where cutaneous, ocular, and nasal exposure becomes even more relevant. These targets are the first barrier that nanoparticles encounter when in contact with the human body. The contributors addresses a representative set of the broad spectrum of nanopharmaceuticals currently being used, including cationic lipid nanoparticles, polymeric PLGA, PLA nanoparticles, biomacromolecules-based nanoparticles, and other scaffolds tissue engineered skin substitutes. Regulation and risk is also covered, since the safety of these nanophamaceuticals still represents a barrier to their wide innovative use.

This book is based on the first edition titled Historical Dictionary of Mozambique - with new entries, updating of information, some reorganisation, and the correction of a few minor errors of fact and interpretation in the earlier work; it is aimed primarily at a South African readership.

The purpose of bringing out this revised edition is to make information on Mozambique more easily available and affordable for students and others in southern Africa who are interested in the history of one of South Africa's closest neighbours. Over several centuries, relations between the two emerging territories have been complex and sometimes troubled, and despite the fact that the economies of the two countries have more recently become historically interdependent, the simple fact that Mozambique is officially – at least, a Portuguese-speaking country has perhaps functioned as a barrier to understanding.

The emphasis in focus is on contemporary history from the middle of the twentieth century onwards, with perhaps one-third of all entries dealing with topics and personalities from that period. However, the dictionary includes many entries covering both the period before the arrival of the Portuguese in the late fifteenth century, as well as on the five centuries of their presence – often precarious – in Mozambique.

The war is over, the dark forces have won, and the hero who was supposed to save them is dead.

Captured as her castle is overrun by the enemy, Princess Briony Rosewood is stripped of her magic and auctioned off to the highest bidder.

She’s sold to Toven Hearst: scion of a family known for their cruel control of magic – and her long-time, and unresolved, infatuation. Yet despite the horrors of her new world and the role she must learn to play within it, all is not lost.

Help – and hope – may yet arise in the most unlikely of places…

The war is over, the dark forces have won, and the hero who was supposed to save them is dead.

Captured as her castle is overrun by the enemy, Princess Briony Rosewood is stripped of her magic and auctioned off to the highest bidder.

She’s sold to Toven Hearst: scion of a family known for their cruel control of magic – and her long-time, and unresolved, infatuation. Yet despite the horrors of her new world and the role she must learn to play within it, all is not lost.

Help – and hope – may yet arise in the most unlikely of places…

Jodi never asked to be a Thrasher – a member of the high school elite. But Jodi has been best friends with Zack Thrasher her whole life, and like it or not, that means she’s branded a Thrasher by the rest of the school. And different as she feels to the other four Thrashers – all talented, privileged and beautiful – she can’t help appreciating her social status, especially compared to her violent home life.

But being a Thrasher isn’t worth dying for – except, apparently, it was to Emily Mills. Sweet but intense Emily, whose fixation on Zack brought her close to the in-crowd, but never close enough. Emily, who took her own life on prom night.

When a detective finds a copy of Emily’s diary, there are whispers that she was ‘Thrashed’ – bullied to death by Zack and his gang. They are arrested, charged, and ostracised, their once bright futures extinguished. Then begin the texts from unfamiliar numbers, inexplicable light flares, the run of bad luck that becomes a string of near-fatal accidents… and the constant dreams of Emily.

But something isn’t adding up. The diary is too convenient. In fact, it’s filled with Jodi’s own secrets, repurposed by Emily. But why?

One thing is clear. Emily isn’t done with the Thrashers.

"Cell niches" are present in several human body tissues as a dynamic microenvironment essential to modulate stem cells' behavior in health, under injury, and in regenerative processes. The interplay between stem cells and their niche is necessary for sustaining tissues. The extracellular matrix (ECM) is the crucial component of the stem cell. It defines the architectural space, physical binding to the cell membrane, and interactions with the neighborhood cells and supports physical stress. Domains with nano or micrometric sizes define the surface and topology of the ECM, mediating cell interactions and macrophage recruitment to injured sites. Over the last two decades, the integration of biomedicine with other engineering and biomaterial sciences promoted the development of nanotechnology and regenerative medicine toward mimicking the specialized stem cell niches to treat diseases with less invasive and efficient therapies. Innovative approaches in nanotechnology, such as targeting the immunological system, transporting drugs across blood-brain/BBB and blood-retinal barriers/BRB, directing active moiety to specific disease location/organs, encapsulation of multiple components, and promoting signalization and pathway-specific surfaces for cell interactions and growth, are indeed promising. On the other side, developments of biomaterial scaffolds to mimic the cell niches for interactions with stem cells in vitro or in vivo have tremendous potential. The three-dimensional printing technology offers a base for a wide array of applications, for example, developing tissue constructs, mimetic organs, organoids, and organ-on-a-chip, thus avoiding the differences between animal model species and humans. Aiming closer to the natural environments, fresh autologous products from the blood, such as platelet-rich plasma (PRP), contain platelets and leukocytes, providing growth factors, cytokines, and proteins for the resident stem cells in the stages of regeneration. PRP also provides pain relief, reducing disabilities in elderly or diseased people. This book brings thought-provoking multidisciplinary topics on the diverse aspects of basic and applied sciences. The prime focus of the compilation is to understand the challenges researchers encounter in combining nanotechnology and regenerative medicine, ultimately integrating both disciplines for the benefit of the patient and offering them a ray of hope to be cured.

The war is over, the dark forces have won, and the hero who was supposed to save them is dead. 

Captured as her castle is overrun by the enemy, the world as Briony Rosewood knows it is changed forever. Evil has won, and her people face imminent servitude, imprisonment, or death. 

​Stripped of her Magic and her freedom, Briony and the other survivors are quickly sold off to the highest bidders in an auction—and as Evermore's princess, she fetches the highest price. After a fierce bidding war, she’s sold to none other than Toven Hearst, scion of a family known for their cruelty. 

Yet despite the horrors of her new world and the role she must learn to play within it, all is not lost. Help—and hope—may yet arise in the most unlikely of places…

Nanoformulation Strategies for Cancer Treatment provides an up-to-date review on current developments and regulatory and clinical challenges in the field of nanopharmaceuticals and the effective treatment of diverse varieties of cancer. This important reference source is ideal for biomaterials scientists and pharmaceutical scientists working in the area of cancer diagnosis and therapy. Due to the high cost of traditional cancer treatment types, researchers have increasingly looked for new ways to augment the therapeutic performance of existing drug candidates. The use of nanotechnology-based approaches have gained significant momentum, thus leading to the launch of a series of new drug products. As nanopharmaceuticals improve the therapeutic performance of cancer therapy drugs, but also provide opportunities for site-specific drug targeting in tumors, this work is a welcomed resource on the topics discussed.

While Cinder dreams of a girl with eyes the colour of the sea, Princess Ella longs for something she cannot yet imagine. When the two girls meet, their hearts are filled with joy, but what will happen when the clock strikes midnight? With one family being a source of encouragement, the other determined to crush all attempts at happiness, the odds are firmly stacked against our heroes. Yet with the power of love and strength, hope prevails. The result is a richly purposeful and inspirational, tale where girl meets girl and love faces adversity. Will Cinder and Ella find their happily ever after?