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Books > Science & Mathematics > Biology, life sciences > Life sciences: general issues
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Nanotechnology and Regenerative Medicine - History, Techniques, Frontiers, and Applications (Paperback)
Loot Price: R4,171
Discovery Miles 41 710
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Nanotechnology and Regenerative Medicine - History, Techniques, Frontiers, and Applications (Paperback)
Expected to ship within 12 - 19 working days
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"Cell niches" are present in several human body tissues as a
dynamic microenvironment essential to modulate stem cells' behavior
in health, under injury, and in regenerative processes. The
interplay between stem cells and their niche is necessary for
sustaining tissues. The extracellular matrix (ECM) is the crucial
component of the stem cell. It defines the architectural space,
physical binding to the cell membrane, and interactions with the
neighborhood cells and supports physical stress. Domains with nano
or micrometric sizes define the surface and topology of the ECM,
mediating cell interactions and macrophage recruitment to injured
sites. Over the last two decades, the integration of biomedicine
with other engineering and biomaterial sciences promoted the
development of nanotechnology and regenerative medicine toward
mimicking the specialized stem cell niches to treat diseases with
less invasive and efficient therapies. Innovative approaches in
nanotechnology, such as targeting the immunological system,
transporting drugs across blood-brain/BBB and blood-retinal
barriers/BRB, directing active moiety to specific disease
location/organs, encapsulation of multiple components, and
promoting signalization and pathway-specific surfaces for cell
interactions and growth, are indeed promising. On the other side,
developments of biomaterial scaffolds to mimic the cell niches for
interactions with stem cells in vitro or in vivo have tremendous
potential. The three-dimensional printing technology offers a base
for a wide array of applications, for example, developing tissue
constructs, mimetic organs, organoids, and organ-on-a-chip, thus
avoiding the differences between animal model species and humans.
Aiming closer to the natural environments, fresh autologous
products from the blood, such as platelet-rich plasma (PRP),
contain platelets and leukocytes, providing growth factors,
cytokines, and proteins for the resident stem cells in the stages
of regeneration. PRP also provides pain relief, reducing
disabilities in elderly or diseased people. This book brings
thought-provoking multidisciplinary topics on the diverse aspects
of basic and applied sciences. The prime focus of the compilation
is to understand the challenges researchers encounter in combining
nanotechnology and regenerative medicine, ultimately integrating
both disciplines for the benefit of the patient and offering them a
ray of hope to be cured.
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