In the past few years, antisense methodology has moved from in vitro studies to in vivo studies and first human trials. While the basic concept of antisense technology is simple, the methodological problems associated with its use are numerous and complex. Antisense- based methods have proven to be a field of research where careful attention to experimental protocols and appropriate controls is necessary. The Manual of Antisense Methodology emphasizes the application of antisense oligonucleotides, and is a guide for the identification of antisense and non-antisense effects in different experimental settings. The work is organized into three sections: antisense application in vitro, antisense application in vivo (animal models) and finally, clinical antisense studies. Where at all possible, the methods are described in sufficient detail to allow reproduction of a given experiment. The Manual of Antisense Methodology will be of interest to researchers in immunology, cancer research, pharmacology and internal medicine; and physicians conducting clinical studies in these fields.

Von der Facebook-Revolution bis zur Info-Atomisierung: Wie konnen sich Menschen in einer zunehmend zersplitterten und uberfluteten Kommunikationswelt uberhaupt noch miteinander verstandigen? Und welche Chancen und Potenziale ergeben sich aus diesem Umbruch?

Im SignsBook diskutieren prominente Marketing- und Kommunikationsexperten, wie die Zukunft der Kommunikation angesichts zunehmender Veranderungen aussehen wird und wie sie aktiv gestaltet werden kann. Neben dem Wandel in der taglichen (Medien-)Kommunikation wird auch der Einfluss neuer Medienformen, neuer Technik und der von Social-Media-Plattformen auf die Qualitat und den Sinngehalt der Informationen und Botschaften untersucht bis hin zu den Auswirkungen im gesellschaftlichen, kulturellen und politischen Bereich. Mit dem SignsBook setzen die Herausgeber und Autoren ein Zeichen fur eine wirkungsvolle, Erfolg bringende Kommunikation, die sich notwendigerweise an Werten wie Nachhaltigkeit, Authentizitat und Glaubwurdigkeit orientiert und dabei innovativ und zeitgemass ist. In diesem Kommunikationsfachbuch kommen neben prominenten Marketing-, Medien- und Kommunikationspersonlichkeiten kommen auch Blogger, Forscher, Fotografen, Musiker und Padagogen zu Wort."

In the past few years, antisense methodology has moved from in vitro studies to in vivo studies and first human trials. While the basic concept of antisense technology is simple, the methodological problems associated with its use are numerous and complex. Antisense- based methods have proven to be a field of research where careful attention to experimental protocols and appropriate controls is necessary. The Manual of Antisense Methodology emphasizes the application of antisense oligonucleotides, and is a guide for the identification of antisense and non-antisense effects in different experimental settings. The work is organized into three sections: antisense application in vitro, antisense application in vivo (animal models) and finally, clinical antisense studies. Where at all possible, the methods are described in sufficient detail to allow reproduction of a given experiment. The Manual of Antisense Methodology will be of interest to researchers in immunology, cancer research, pharmacology and internal medicine; and physicians conducting clinical studies in these fields.