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This book reviews the principles of design and examples of
successful implementation of proteinkinase inhibitors (PKI), and
offers a comprehensive and authoritative overview of the history
and latest developments in the field. Chapters written by experts
from industry and academia cover the function, structure and
topology of Proteinkinases, molecular modelling, disclose how to
achieve high level of selectivity for kinase inhibitors, and
exploit kinase inhibitors for cancer treatment. Particular
attention is given to Inhibitors of c-Jun N-terminal kinase 3, and
to covalent Janus Kinase 3 Inhibitors. A case study on Receptor
Tyrosine Kinases EGFR, VEGFR, PDGFR is also presented in this book.
Given its breath, this book will appeal to medicinal chemists,
students, researchers and professionals alike.
This book reviews the principles of design and examples of
successful implementation of proteinkinase inhibitors (PKI), and
offers a comprehensive and authoritative overview of the history
and latest developments in the field. Chapters written by experts
from industry and academia cover the function, structure and
topology of Proteinkinases, molecular modelling, disclose how to
achieve high level of selectivity for kinase inhibitors, and
exploit kinase inhibitors for cancer treatment. Particular
attention is given to Inhibitors of c-Jun N-terminal kinase 3, and
to covalent Janus Kinase 3 Inhibitors. A case study on Receptor
Tyrosine Kinases EGFR, VEGFR, PDGFR is also presented in this book.
Given its breath, this book will appeal to medicinal chemists,
students, researchers and professionals alike.
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