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Die Entwicklung und Einf hrung von Next-Generation
Sequencing-Technologien ver ndern die M glichkeiten f r
Transkriptomstudien immens. Mit der Leistungsf higkeit der
momentanen Sequenziertechnologien k nnen Millionen von Sequenzen in
k rzester Zeit sequenziert werden. Mit PASSAGE wird in diesem Buch
ein Verfahren zur genomweiten Genexpressionsanalyse ohne ein
Referenzgenom vorgestellt. Neben der Analyse von Einzelzellen wird
aufgezeigt wie mit PASSAGE auch die Analyse von Metatranskriptomen
m glich ist. Ist ein Referenzgenom vorhanden so kann mit PASSAGE
der Aufwand der Betrachtung der einzelnen Sequenzen mit eben diesem
Verfahren deutlich reduziert werden. Neben der reinen Analyse der
Daten wird zudem eine grafische Benutzeroberfl che zur
Visualisierung der Ergebnisse vorgestellt. Damit wird dem Anwender
eine u erst effiziente Analyse der Daten erm glicht. Der Vergleich
mit Microarray-Ergebnissen zeigt die Validit t dieses Verfahrens
zur genomweiten Genexpressionsanalyse an Einzelzellen oder von
Metatranskriptomen.
This book covers a wide spectrum of connected topics in the field
of practical and moral thinking. It contains papers and discussions
on the logic of practical reasoning and moral obligation; on the
decision-theoretical approach to morality; on the relation between
practical and theoretical reason; and on the political aspects of
morality. The contributors are, for the most part, well-known
philosophers who have not been content with merely restating their
positions, but have sued this as a forum for proposing new ideas.
The value of the collection lies not only in the originality of the
contributions on the various topics mentioned but equally in its
demonstration of the interrelations among these topics.
This is an ambitious and substantial study of metaphysics: its
nature and inescapability. Professor Koerner's method may be
described as 'philosophical anthropology', and aims to arrive at a
characterisation of the metaphysical beliefs with which we (have
to) operate. Professor Koerner begins by describing how the
categorical framework of a person's metaphysical beliefs may be
embedded in more ordinary beliefs and practical attitudes to the
world. He illustrates the variety of such frameworks and describes
their role, going on to explain how they may be modified by
argument and reflection. This is an independent inquiry, but also
the culmination of a series of Professor Koerner's earlier works.
The writing is extremely clear and the material sensitively
controlled, revealing great learning and many suggestive insights
and comparisons. It presents overall a comprehensive and carefully
thought-out account of metaphysics.
First published in 1976, this is a comprehensive study of practical
thinking. Professor Koerner shows the complex relations which a
person's practical attitudes bear to each other, and shows in
particular how their moral or prudential character depends not only
on their content and form but also on their place in the system
constituted by them. There are detailed accounts of the concepts of
morality, prudence, justice, welfare and legality, as well as the
logical foundations, epistemology and metaphysics of practical
thinking. The book is intended for philosophers and for those
political theorists and social scientists who are concerned with
the philosophical presuppositions and implications of their
enquiries. The book is deliberately organized so that those with
less interest in the logical issues dealt with in Part I can
proceed quickly and easily to the more substantive issues in Parts
II and III.
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