Mendelian Randomization: Methods For Causal Inference Using Genetic Variants provides thorough coverage of the methods and practical elements of Mendelian randomization analysis. It brings together diverse aspects of Mendelian randomization from the fields of epidemiology, statistics, genetics, and bioinformatics. Through multiple examples, the first part of the book introduces the reader to the concept of Mendelian randomization, showing how to perform simple Mendelian randomization investigations and interpret the results. The second part of the book addresses specific methodological issues relevant to the practice of Mendelian randomization, including robust methods, weak instruments, multivariable methods, and power calculations. The authors present the theoretical aspects of these issues in an easy-to-understand way by using non-technical language. The last part of the book examines the potential for Mendelian randomization in the future, exploring both methodological and applied developments. Features Offers first-hand, in-depth guidance on Mendelian randomization from leaders in the field Makes the diverse aspects of Mendelian randomization understandable to newcomers Illustrates technical details using data from applied analyses Discusses possible future directions for research involving Mendelian randomization Software code is provided in the relevant chapters and is also available at the supplementary website This book gives epidemiologists, statisticians, geneticists, and bioinformaticians the foundation to understand how to use genetic variants as instrumental variables in observational data. New in Second Edition: The second edition of the book has been substantially re-written to reduce the amount of technical content, and emphasize practical consequences of theoretical issues. Extensive material on the use of two-sample Mendelian randomization and publicly-available summarized data has been added. The book now includes several real-world examples that show how Mendelian randomization can be used to address questions of disease aetiology, target validation, and drug development

Mendelian Randomization: Methods For Causal Inference Using Genetic Variants provides thorough coverage of the methods and practical elements of Mendelian randomization analysis. It brings together diverse aspects of Mendelian randomization from the fields of epidemiology, statistics, genetics, and bioinformatics. Through multiple examples, the first part of the book introduces the reader to the concept of Mendelian randomization, showing how to perform simple Mendelian randomization investigations and interpret the results. The second part of the book addresses specific methodological issues relevant to the practice of Mendelian randomization, including robust methods, weak instruments, multivariable methods, and power calculations. The authors present the theoretical aspects of these issues in an easy-to-understand way by using non-technical language. The last part of the book examines the potential for Mendelian randomization in the future, exploring both methodological and applied developments. Features Offers first-hand, in-depth guidance on Mendelian randomization from leaders in the field Makes the diverse aspects of Mendelian randomization understandable to newcomers Illustrates technical details using data from applied analyses Discusses possible future directions for research involving Mendelian randomization Software code is provided in the relevant chapters and is also available at the supplementary website This book gives epidemiologists, statisticians, geneticists, and bioinformaticians the foundation to understand how to use genetic variants as instrumental variables in observational data. New in Second Edition: The second edition of the book has been substantially re-written to reduce the amount of technical content, and emphasize practical consequences of theoretical issues. Extensive material on the use of two-sample Mendelian randomization and publicly-available summarized data has been added. The book now includes several real-world examples that show how Mendelian randomization can be used to address questions of disease aetiology, target validation, and drug development

Small businesses make up some 90-95 percent of all global firms. Many undervalue the importance of information and communication technology (ICT). Within the small business segment there can be significant differences amongst the avid early adopters of ICT and the laggards. Research on early adopters tends be more prevalent as they are perceived to have a more interesting and positive story. However, late adopters and 'laggards' also have their own interesting stories that are under-reported. Small Business and Effective ICT draws on research undertaken over several years and documents the adoption/use of ICT across 'better' users of ICT (Leaders), typical ICT users (Operationals) and late adopters (Laggards). The findings are presented using a re-formulation of the LIASE framework which addresses a number of areas that include ICT literacy (L), information content/communication (I), Access (A), Infrastructure (I), Support (S) and Evaluation (E). Some 60 businesses were investigated in Australia and the UK, with each business presented as a concise vignette. The vignettes serve to show that small businesses are not as conservative in their use of ICT as the literature suggests, with examples of innovative uses of ICT in small businesses provided. Lessons for the effective use of ICT by small businesses are presented. The research design, methods adopted, presentation of findings through the vignettes, and 'take away' lessons have been written in manner to appeal to a broad range of readers including academics, researchers, students and policy makers in the discipline.

Small businesses make up some 90-95 percent of all global firms. Many undervalue the importance of information and communication technology (ICT). Within the small business segment there can be significant differences amongst the avid early adopters of ICT and the laggards. Research on early adopters tends be more prevalent as they are perceived to have a more interesting and positive story. However, late adopters and 'laggards' also have their own interesting stories that are under-reported. Small Business and Effective ICT draws on research undertaken over several years and documents the adoption/use of ICT across 'better' users of ICT (Leaders), typical ICT users (Operationals) and late adopters (Laggards). The findings are presented using a re-formulation of the LIASE framework which addresses a number of areas that include ICT literacy (L), information content/communication (I), Access (A), Infrastructure (I), Support (S) and Evaluation (E). Some 60 businesses were investigated in Australia and the UK, with each business presented as a concise vignette. The vignettes serve to show that small businesses are not as conservative in their use of ICT as the literature suggests, with examples of innovative uses of ICT in small businesses provided. Lessons for the effective use of ICT by small businesses are presented. The research design, methods adopted, presentation of findings through the vignettes, and 'take away' lessons have been written in manner to appeal to a broad range of readers including academics, researchers, students and policy makers in the discipline.

Negotiating a peaceful end to civil wars, which often includes an attempt to bring together former rival military or insurgent factions into a new national army, has been a frequent goal of conflict resolution practitioners since the Cold War. In practice, however, very little is known about what works, and what doesn't work, in bringing together former opponents to build a lasting peace. Contributors to this volume assess why some civil wars result in successful military integration while others dissolve into further strife, factionalism, and even renewed civil war. Eleven cases are studied in detail-Sudan, Zimbabwe, Lebanon, Rwanda, the Philippines, South Africa, Mozambique, Bosnia-Herzegovina, Sierra Leone, Democratic Republic of the Congo, and Burundi-while other chapters compare military integration with corporate mergers and discuss some of the hidden costs and risks of merging military forces. New Armies from Old fills a serious gap in our understanding of civil wars, their possible resolution, and how to promote lasting peace, and will be of interest to scholars and students of conflict resolution, international affairs, and peace and security studies.

In many countries, small businesses comprise over 95% of the proportion of private businesses and approximately half of the private workforce, with information technology being used in more than 90% of these businesses. As a result, governments worldwide are placing increasing importance upon the success of small business entrepreneurs and are providing increased resources to support this emphasis. Managing Information Technology in Small Business: Challenges and Solutions presents research in areas such as IT performance, electronic commerce, internet adoption, and IT planning methodologies and focuses on how these areas impact small businesses.

Over the past several years, a great deal of research has been devoted to the use of information technology by small businesses. One technological tool now used to boost company success is Web presence enhancement in alignment with business strategy. ""Effective Web Presence Solutions for Small Businesses: Strategies for Successful Implementation"" is the first book to provide small businesses with a holistic approach to implementing their Web presence through identification of Web site content that matches their business strategy. A valuable read for small business owners as well as academicians and researchers, this book connects the various issues involved in the planning and execution of successful Web sites for small businesses.