A chance meeting at a dinner party in Paris turns the life of Philip Reid, an aging and cynical American diplomat, upside down, sending him back more than twenty years to when he had been a younger and better man. In those days, for a brief moment, Bandula, scion of the island's most powerful family, had been Philip’s closest friend. Now, he finds his onetime companion bitter and humbled by life. In a tale marked by terrorist bombings, political assassination, romance, and intrigue, we follow the tragedies that lead Bandula to a life in exile and Philip to the attainment of dreams that lose their meaning even in the moment of their fulfillment. In their serendipitous meeting, both men gain a chance at redeeming the past.

This timely volume brings together the latest basic and clinical insights on the cellular and mediator mechanisms involved in the induction and persistence of airway dysfunction of asthma by over 90 experts in the field-paving the way for developing novel and more effective antiinflammatory therapeutic agents and strategies.
Furnishing a comprehensive and up-to-date view of the expanding and interrelated components underlying asthma pathogenesis, Inflammatory Mechanisms in Asthma
describes how evidence on airway inflammation is obtained with invasive and noninvasive procedures, such as bronchoalveolar lavage and sputum analysis
reviews the complex interactions of inflammatory cells that contribute to chronic inflammation and bronchial hyperreactivity, including eosinophils, basophils, neutrophils, fibroblasts, epithelial cells, and macrophages
considers mast cells, cytokines, neural factors, leukotrienes, kinins, and other mediators that regulate the development, establishment, or resolution of asthma exacerbations
presents new information suggesting that airway changes in asthma can lead to remodeling or airway fibrosis
and more
Enhanced with over 4700 references, tables, drawings, and photographs, this compelling investigation into the pathophysiology of asthma is an indispensable resource for pulmonologists, physiologists, immunologists, allergists, epidemiologists, biochemists, molecular biologists, and graduate and medical school students in these disciplines.

The increasing incidence and prevalence of allergic disease worldwide is one of the most remarkable phenomena of the past 50 years. One in three people in developed countries will experience an allergic condition at some point in their lives and advances in understanding the causes of this trend, and in allergy treatment and care, have captured the imagination of scientists, clinicians and the public. Landmark Papers in Allergy is a definitive collection of over 90 papers charting key discoveries and scientific advances in relation to allergy and the development of treatment and care for allergic disorders. Comprehensive in its coverage, the book includes the first clear descriptions of allergic diseases; the major advances in treatments, such as the discovery of antihistamines, cortisone, biological therapies and immunotherapy; the great immunological advances, such as the discovery of immunoglobulin E (IgE) and leukotrienes; the possible factors behind the increase in allergy, such as the house dust mite, changes in hygiene and diet; and the growing understanding of the social, psychological and quality-of-life consequences of allergy. Including authoritative commentaries from leading international experts providing reflections on the historical importance and current relevance of each landmark paper, Landmark papers in Allergy is essential reading for any clinician or academic with an interest in allergy.

This study of Hegel and Nietzsche evaluates and compares their work through their common criticism of the metaphysics for operating with conceptual oppositions such as being/becoming and egoism/altruism. Dr Houlgate exposes Nietzsche’s critique as employing the distinction of Life and Thought, which itself constitutes a metaphysical dualism of the kind Nietzsche attacks. By comparison Hegel is shown to provide a more profound critique of metaphysical dualism by applying his philosophy of the dialectic, which sees such alleged opposites as defining components of a dynamic. In choosing to study a theme so fundamental to both philosophers’ work, Houlgate has established a framework within which to evaluate the Hegel-Nietzsche debate; to make the first full study of Nietzsche’s view of Hegel’s work; and to compare Nietzsche’s Dionysic philosophy with Hegel’s dialectical philosophy by focusing on tragedy, a subject central to the philosophy of both.

Hegel on Being provides an authoritative treatment of Hegel's entire logic of being. Stephen Houlgate presents the Science of Logic as an important and neglected text within Hegel's oeuvre that should hold a more significant place in the history of philosophy. In the Science of Logic, Hegel set forth a distinctive conception of the most fundamental forms of being through ideas on quality, quantity and measure. Exploring the full trajectory of Hegel's logic of being from quality to measure, this two-volume work by a preeminent Hegel scholar situates Hegel's text in relation to the work of Plato, Aristotle, Descartes, Spinoza, Kant, and Frege. Volume I: Quality and the Birth of Quantity in Hegel's 'Science of Logic' covers all material on the purpose and method of Hegel's dialectical logic and charts the crucial transition from the concept of quality to that of quantity, as well as providing an original account of Hegel's critique of Kant's antinomies across two chapters. Volume II: Quantity and Measure in Hegel's 'Science of Logic' continues the discussion of Hegel's logic of being and considers all aspects of quantity and measure in his logic, including his basic categories of being, writings on calculus, philosophy of mathematics, as well as a comparative study of Hegel and Frege's approach to logic. Lucidly written, with characteristic philosophical depth and analysis, Houlgate's Hegel on Being explicates one of Hegel's most complex works, providing a vital reference for a generation of Hegel scholars and a major contribution to the literature on 19th century German philosophy.

What is rational is actual and what is actual is rational. Hegel's Outlines of the Philosophy of Right is one of the greatest works of moral, social, and political philosophy. It contains significant ideas on justice, moral responsibility, family life, economic activity, and the political structure of the state - all matters of profound interest to us today. Hegel's aim is to lay out the various forms that human freedom must take on, if it is to be true freedom. He seeks to show that genuine human freedom does not consist in doing whatever we please, but involves living with others in accordance with publicly recognized rights and laws. Hegel demonstrates that institutions such as the family and the state provide the context in which individuals can flourish and enjoy full freedom. He also demonstrates that misunderstanding the true nature of freedom can lead to crime, evil, and poverty. His penetrating analysis of the causes of poverty in modern civil society was to be a great influence on Karl Marx. Hegel's study remains one of the most subtle and perceptive accounts of freedom that we possess. This new edition combines a revised translation with a cogent introduction to his work. ABOUT THE SERIES: For over 100 years Oxford World's Classics has made available the widest range of literature from around the globe. Each affordable volume reflects Oxford's commitment to scholarship, providing the most accurate text plus a wealth of other valuable features, including expert introductions by leading authorities, helpful notes to clarify the text, up-to-date bibliographies for further study, and much more.

Hegel's "Phenomenology of Spirit" is probably his most famous work. First published in 1807, it has exercised considerable influence on subsequent thinkers from Feuerbach and Marx to Heidegger, Kojeve, Adorno and Derrida. The book contains many memorable analyses of, for example, the master / slave dialectic, the unhappy consciousness, Sophocles' "Antigone" and the French Revolution and is one of the most important works in the Western philosophical tradition. It is, however, a difficult and challenging book and needs to be studied together with a clear and accessible secondary text. Stephen Houlgate's Reader's Guide offers guidance on: Philosophical and historical contextKey themesReading the textReception and influenceFurther reading

Hegel is one of the most importantmodern philosophers, whose thought influenced the development ofexistentialism, Marxism, pragmatism, hermeneutics, and deconstruction. YetHegel's central text, the monumental Science of Logic, still remains formost philosophers (both figuratively and literally) a firmly closed book. Thepurpose of The Opening of Hegel's Logic is to dispel the myths thatsurround the Logic and to show that Hegel's unjustly neglected text is awork of extraordinary subtlety and insight. Part One of The Opening of Hegel's Logic argues that the Logicprovides a rigorous derivation of the fundamental categories of thought andcontrasts Hegel's approach to the categories with that of Kant. It goes on toexamine the historical and linguistic presuppositions of Hegel's self-critical,"presuppositionless" logic and, in the process, considers severalsignifi cant criticisms of such logic advanced by Schelling, Feuerbach,Gadamer, and Kierkegaard. Separate chapters are devoted to the relation betweenlogic and ontology in Hegel's Logicand to the relation between the Logicitself and the Phenomenology. PartTwo contains the text - in German and English - of the firsttwo chapters of Hegel's Logic, whichcover such categories as being, becoming, something, limit, finitude, andinfinity. Part Three then provides a clear and accessible commentary on thesetwo chapters that both examines Hegel's arguments in detail and relates hisinsights to those of other philosophers, such as Descartes, Spinoza, Kant,Nietzsche, and Levinas. TheOpening of Hegel's Logic aims tohelp students and scholars read Hegel's often formidably difficult text forthemselves and discover the wealth of philosophical riches that it contains. Italso argues that Hegel's project of a presuppositionless science of logic isone that deserves serious consideration today.

An American diplomat--reformed alcoholic, unreformed gambler, and inveterate smart-ass-- finds himself under threat of disgrace and murder even as he seeks love and redemption on the strange and spirit-ridden island of Madagascar. Author Steve Holgate brings the mystery and mysticism of Madagascar to life in his haunting and exciting second novel. 

Hegel's Phenomenology of Spirit is probably his most famous work. First published in 1807, it has exercised considerable influence on subsequent thinkers from Feuerbach and Marx to Heidegger, Kojeve, Adorno and Derrida. The book contains many memorable analyses of, for example, the master / slave dialectic, the unhappy consciousness, Sophocles' Antigone and the French Revolution and is one of the most important works in the Western philosophical tradition. It is, however, a difficult and challenging book and needs to be studied together with a clear and accessible secondary text. Stephen Houlgate's Reader's Guide offers guidance on: Philosophical and historical context Key themes Reading the text Reception and influence Further reading

This study of Hegel and Nietzsche evaluates and compares their work through their common criticism of the metaphysics for operating with conceptual oppositions such as being/becoming and egoism/altruism. Dr Houlgate exposes Nietzsche's critique as employing the distinction of Life and Thought, which itself constitutes a metaphysical dualism of the kind Nietzsche attacks. By comparison Hegel is shown to provide a more profound critique of metaphysical dualism by applying his philosophy of the dialectic, which sees such alleged opposites as defining components of a dynamic. In choosing to study a theme so fundamental to both philosophers' work, Houlgate has established a framework within which to evaluate the Hegel-Nietzsche debate; to make the first full study of Nietzsche's view of Hegel's work; and to compare Nietzsche's Dionysic philosophy with Hegel's dialectical philosophy by focusing on tragedy, a subject central to the philosophy of both.