Extracted from the Drug Abuse Handbook, 2nd edition, to give you just the information you need at an affordable price.

Beginning with a detailed look at individual drugs and their effects on the brain, Neurochemistry of Abused Drugs considers the changes in neurotransmitter levels and discusses the relationship of these changes to the nature and phenomenon of addiction. New studies highlight the addictive capacity of nicotine as well as introduce novel compounds that may aid in tobacco cessation. Chapters examine nicotine dependant neuroplasticity and the various neurochemical substrates that support and promote addiction including cholinergic, dopaminergic, and GABAergic adaptations. The book also offers detailed information on the neurochemical and neurobehavioral consequences of MDMA, methamphetamine, and cocaine use. Recent discoveries on the neurotransmitter systems involved in each of these drugs reveal new therapeutic targets for alleviating addiction including ibogaine, and GABA and glutamate receptors. Extensively referenced and citing numerous up-to-date studies, this book provides unparalleled insight into the action and potential inhibition of drugs of abuse.

Extracted from the Drug Abuse Handbook, 2nd edition, to give you just the information you need at an affordable price.

Pharmacokinetics and Pharmacodynamics of Abused Drugs is a concise and focused volume devoted to the metabolism and measurable effects of drugs on the human body. Beginning with basic concepts and models designed to provide a fundamental understanding of the subject matter, the book details the specifics of absorption, distribution, and elimination pathways and rates of commonly abused drugs. It analyzes the effects of drug use on human performance including response time, memory and recall, logical and cognitive processes, as well as physiological changes. Packed with data and comparative studies, this handy volume considers the effects of marketed and prescription medications as well as illicit drugs including opioids, cannabis, cocaine, methamphetamine, MDMA, ketamine, nicotine, and LSD. Containing 29 figures and tables and extensive references, this is a must-have resource for the influence of drug use and abuse on human physiology and performance.

Extracted from the Drug Abuse Handbook, 2nd edition, to give you just the information you need at an affordable price. Forensic Issues in Alcohol Testing offers concise and focused information specific to the interests of forensic scientists and clinical and forensic toxicologists. It analyzes the acute effects of alcohol intoxication and the methods by which investigators can measure alcohol concentration in blood, urine, and breath. It considers extenuating circumstances affecting acute impairment by detailing the disposition and fate of alcohol in the body as well as the factors influencing absorption, distribution, and elimination. Specific chapters address difficulties in measuring and interpreting post-mortem alcohol concentrations due to poor quality of specimen, sampling site differences, and post-mortem diffusion or synthesis. Recent advances in biochemical testing make it possible to quantitate chronic alcohol ingestion, and the book analyzes the efficacy of these tests as evaluators of dependence or potential for dependence.

Karch's Drug Abuse Handbook, Third Edition remains the quintessential compendium addressing the pharmacological, medical, and legal aspects of drugs and informing the forensic community of the latest scientific advances and emergent practices. For this edition, Dr. Karch has brought on clinical and forensic toxicology expert Dr. Bruce Goldberger, editor-in-chief of the Journal of Analytical Toxicology and president of the American Board of Forensic Toxicology, to serve as co-editor. In addition, world-renowned scientists and medical professionals have contributed their work and expertise in tackling the latest developments in drug testing, drug-related medical emergencies, and the drug toxicology. Topics addressed include genetic testing in drug death investigation, pathology, toxicogenetics, alcohol, post-mortem toxicology, new psychoactive substances, the latest legal issues and challenges as well as drugs and drug testing in sports, and the ethical, legal, and practical issues involved. Vivid pictures and diagrams throughout illustrate the pathological effects of drugs and the chemical make-up and breakdown of abused drugs. With unparalleled detail, the latest research and the highest level of authoritative medical scientific information, The Drug Abuse Handbook, Third Edition remains the definitive resource for drug related issues.

Written in the same accessible manner as previous editions, the fifth edition of Karch's Pathology of Drug Abuse is an essential guide to the pathology, toxicology, and pharmacology of commonly abused drugs. The book focuses on the investigation of drug-related deaths, practical approaches to the detection of drug abuse, and discussions of medical complications associated with each of the abused drugs. The Fifth Edition Now Features: Completely revised with hundreds of pages of wholly new coverage Extensive discussion of new synthetic cannabinoids and cathinone derivatives Expanded coverage of the functional and molecular pharmacology of cocaine and myocardial remodeling Expanded discussion of deaths related to prescription medications Detailed suggestions on the interpretation of postmortem drug measurements Many new high resolution full-color photomicrographs Additional, helpful new appendices on standard reference values Separate chapters are devoted to cocaine, naturally occurring stimulants, synthetic stimulants, hallucinogens, narcotics, anabolic steroids, disassociative anesthetics, solvent abuse, and marijuana. The book also offers detailed information on the origins, history, and production techniques used to make many of these drugs. Updated, revised, and newly illustrated, Karch's Pathology of Drug Abuse, Fifth Edition is a must-have reference for research and practice related to drug abuse. Steven B. Karch also discusses the book in a video on the CRC Press YouTube channel.

Written in the same accessible manner as previous editions, the fifth edition of Karch's Pathology of Drug Abuse is an essential guide to the pathology, toxicology, and pharmacology of commonly abused drugs. The book focuses on the investigation of drug-related deaths, practical approaches to the detection of drug abuse, and discussions of medical complications associated with each of the abused drugs. The Fifth Edition Now Features: Completely revised with hundreds of pages of wholly new coverage Extensive discussion of new synthetic cannabinoids and cathinone derivatives Expanded coverage of the functional and molecular pharmacology of cocaine and myocardial remodeling Expanded discussion of deaths related to prescription medications Detailed suggestions on the interpretation of postmortem drug measurements Many new high resolution full-color photomicrographs Additional, helpful new appendices on standard reference values Separate chapters are devoted to cocaine, naturally occurring stimulants, synthetic stimulants, hallucinogens, narcotics, anabolic steroids, disassociative anesthetics, solvent abuse, and marijuana. The book also offers detailed information on the origins, history, and production techniques used to make many of these drugs. Updated, revised, and newly illustrated, Karch's Pathology of Drug Abuse, Fifth Edition is a must-have reference for research and practice related to drug abuse. Steven B. Karch also discusses the book in a video on the CRC Press YouTube channel.

Extracted from the Drug Abuse Handbook, 2nd edition, to give you just the information you need at an affordable price.

Postmortem Toxicology of Abused Drugs considers the role of toxicology in the investigation of homicide, suicide, accident, natural death, and overdose. It gives practical insights and case reviews on conducting toxicology tests and completing toxicology reports. It explains chain of custody; specimen collection and security; sampling of blood, urine, bile, and vitreous humor; and the selection of post-mortem specimens. Analyzing various testing procedures, the book covers simple chemical tests, microdiffusion tests, chromatography, spectroscopy, and more. It also discusses methods and strategies for analysis; and covers quality assurance protocols and controls. To help avoid common pitfalls, the text demonstrates the proper interpretation of postmortem drug levels based on knowledge of pharmacokinetics, metabolism, and pharmacogenetics; post-mortem redistribution and diffusion; and other considerations such as synergistic toxicity, and drug instability. Heavily referenced and containing several tables, figures, and useful appendices, this book is a handy reference for forensic scientists and medical examiners involved with death investigation.

Extracted from the Drug Abuse Handbook, 2nd edition, to give you just the information you need at an affordable price.

Using sample protocols from the transportation and nuclear power industries, Workplace Drug Testing reviews current federal regulations and mandatory guidelines for federal workplace testing programs and demonstrates practical techniques for specimen collection and laboratory testing. The book compares workplace testing outside the US including protocols, attitude surveys, and legislation from Europe, Australia and South America. Chapters include analytical approaches for sample testing such as radioimmunoassay and enzyme immunoassay, as well as confirmatory testing via quality assurance, calibrators, and controls. The book also offers analytical information for biological matrices other than urine; details the procedures for using hair, oral fluid, and sweat; and examines the physiologic considerations when interpreting alternative matrix testresults. Containing numerous tables and figures, expert data, and supported by extensive references, this is a crucial tool for those charged with maintaining a drug-free workplace.

A Brief History of Cocaine, Second Edition provides a fascinating historical insight into the reasons why cocaine use is increasing in popularity and why the rise of the cocaine trade is tightly linked with the rise of terrorism The author illustrates the challenges faced by today's governments and explains why current anti-drug efforts have had only a limited effect on this global market. This updated edition reexamines the impact of cocaine production, trade, and consumption on society beginning in the 16th century. It shows how the commercialization of cocaine was driven by cartels of Swiss and German pharmaceutical companies and private enterprises across Europe, Asia, and the United States. The author shows how government policies slowly transformed from trade, shipping, and manufacturing regulations, with little or no success in stemming the flow of drugs. The book describes how anti-drug laws, treaties, and costly initiatives involving crop substitution, crop suppression, interdiction, and international cooperation were first attempted more than 400 years ago and why these strategies failed for Colonial Spain and later backfired on the League of Nations. The author shows how economic necessity among growers, the environmental impact of pesticides, the potential for genetic engineering of coca plants, and other loopholes have actually been counterproductive, undermining the current efforts to curb the cocaine trade. Featuring new and reorganized chapters, A Brief History of Cocaine, Second Edition contains the latest data and statistics relating drug trafficking to terrorism, and explains recent trends in worldwide production, consumption, cost competition, and international transport. This book offers a well-rounded historical perspective that is ideal for criminal justice practitioners, teachers, students, and anyone interested in this topic.

This book provides protocols for suicide and equivocal death investigation, police action shooting investigations and a homicide supervisor's checklist. It contains state-of-the-art anatomical graphics in full color to assist the investigator in describing any injuries or wounds to the body.

A Brief History of Cocaine, Second Edition provides a fascinating historical insight into the reasons why cocaine use is increasing in popularity and why the rise of the cocaine trade is tightly linked with the rise of terrorism The author illustrates the challenges faced by today's governments and explains why current anti-drug efforts have had only a limited effect on this global market. This updated edition reexamines the impact of cocaine production, trade, and consumption on society beginning in the 16th century. It shows how the commercialization of cocaine was driven by cartels of Swiss and German pharmaceutical companies and private enterprises across Europe, Asia, and the United States. The author shows how government policies slowly transformed from trade, shipping, and manufacturing regulations, with little or no success in stemming the flow of drugs. The book describes how anti-drug laws, treaties, and costly initiatives involving crop substitution, crop suppression, interdiction, and international cooperation were first attempted more than 400 years ago and why these strategies failed for Colonial Spain and later backfired on the League of Nations. The author shows how economic necessity among growers, the environmental impact of pesticides, the potential for genetic engineering of coca plants, and other loopholes have actually been counterproductive, undermining the current efforts to curb the cocaine trade. Featuring new and reorganized chapters, A Brief History of Cocaine, Second Edition contains the latest data and statistics relating drug trafficking to terrorism, and explains recent trends in worldwide production, consumption, cost competition, and international transport. This book offers a well-rounded historical perspective that is ideal for criminal justice practitioners, teachers, students, and anyone interested in this topic.

This practical how-to guide contains checklists that lead investigators step-by-step through procedures, tactics, and forensic techniques used in sudden death and violent death investigations. The new edition is enhanced with full-colour medicological illustrations and contains expanded checklists on evidence collections and advice to first responders.

Extracted from the Drug Abuse Handbook, 2nd edition, to give you just the information you need at an affordable price. Addiction and the Medical Complications of Drug Abuse explores the physiological and psychological phenomenon of addiction including the nature of dependence, the dependence potential of drugs, and the importance of motivation. Contributions analyze the practice of substitute prescribing and detail the immediate and long term benefits of their use in maintenance or controlled withdrawal from opioids, stimulants, and benzodiazepines. It considers the use of methadone, buprenorphine, adrenergic agonists, and naltrexone for detoxification. Practitioners will benefit from the expert instruction on the management of common comorbidities, including diagnosis and pharmaceutical treatment of psychological disorders. Additional information covers the physiological effects of each drug and the emergency management of several drug related disorders such as psychosis, seizures, stroke, hyperthermia, and cardiac crisis. With 29 tables and figures, expert data and extensive references, this is an indispensable book for anyone in the field of addiction or emergency medicine.

Extracted from the Drug Abuse Handbook, 2nd edition, to give you just the information you need at an affordable price. Pathology, Toxicogenetics, and Criminalistics of Drug Abuse presents a detailed introduction to the cutting-edge advances in this emerging field. Beginning with a definition and explanation of the scheduling of controlled substances, the book covers all illicit drugs, as well as several legitimate pharmaceutical preparations that are used illicitly, including steroids. It describes in detail the most common pathologic syndromes seen in the hearts, lungs, and central nervous systems of drug abusers and explains how inherited genetic defects and variations can alter drug effects. Written by leading investigators in the field, this useful volume describes the techniques most commonly used by forensic analysts including chemical confirmatory tests such as microcrystal identification and gas chromatography/mass spectrometry. The book reviews the basics of toxicogenetics, including the molecular changes in cardiac structure ("channelopathies") that may cause sudden death.