Contents:
EPIDEMIOLOGY
Blazer, D.G., Kessler, R.C., McGonagle, K.A., and Swartz, M.S. 'The Prevalence and Distribution of Major Depression in a National Community Sample: The National Comorbidity Survey.' American Journal of Psychiatry 151 (1994).
Burke, K.C., Burke, J.D. Jr., Rae, D.S. and Regier, D.A. 'Comparing Age at Onset of Major Depression and Other Psychiatric Disorders by Birth Cohorts in Five US Community Populations.' Archives of General Psychiatry 48 (1991)
Judd, L.L., Paulus, M.P., Wells, K.B. and Rapoport, M.H. 'Socioeconomic Burden of Subsyndromal Depressive Symptoms and Major Depression in a Sample of the General Population.' American Journal of Psychiatry 153 (1996).
Murphy, J.M., Laird, N.M., Monson, R.R., Sobol, A.M., and Leighton, A.H. 'A 40-Year Perspective on the Prevalence of Depression.' Archives of General Psychiatry 57 (2000).

NATURAL HISTORY
Kessler, R.C. 'The Effects of Stressful Life Events on Depression.' Annual Review of Psychology 48 (1997).

DEPRESSION AND MEDICAL DISORDERS
Krishnan, K.R., Hays, J.C., and Blazer, D.G., 'MRI Defined Vascular Depression.' American Journal of Psychiatry 154 (1997).
Musselman, D.L., Evans, D.L., and Nemeroff, C.B. 'The Relationship of Depression to Cardiovascular Disease: Epidemiology, Biology, and Treatment.' Archives of General Psychiatry 55 (1998).

GENES AND ENVIRONMENT
Kendler, K.S., Heath, A.C., Martin, N.G., and Eaves, L.J. 'Symptoms of Anxiety and Symptoms of Depression. Same Genes, Different Environments?' Archives of General Psychiatry 44 (1987).
Malhi, G.S., Moore, J., and McGuffin, P. 'The Genetics of Major Depressive Disorder.' Current Psychiatry Reports (2000).
Sullivan, P.F., Neale, M.C., and Kendler, K.S. 'Genetic Epidemiology of Major Depression: Review and Meta-Analysis.' American Journal of Psychiatry 157 (2000).
Weiss, E.L., Longhurst, J.G., and Mazure, C. 'Childhood Sexual Abuse as a Risk Factor for Depression in Women: Psychosocial and Neurobiological Correlates.' American Journal of Psychiatry 156 (1999).

EVOLUTION
Nesse, R.M. 'Is Depression an Adaptation?' Archives of General Psychiatry 57 (2000).

NEUROBIOLOGY AND BEHAVIOUR
Drevets, W.C., Price, J.L., Simpson, J.R., Todd, R.D., Reich, T., Vannier, M., and Raichle, M.E., 'Subgenual Prefrontal Cortex Abnormalities in Mood Disorders.' Nature 386 (1997).
Duman, R.S., Heniger, G.R., and Nestler, E.J. 'A Molecular and Cellular Theory of Depression.' Archives of General Psychiatry 54 (1997).
Heim, C. and Nemeroff, C.B. 'The Impact of Early Adverse Experiences on Brain Systems Involved in the Pathophysiology of Anxiety and Effective Disorders.' Biological Psychiatry 46 (1999).
Holsboer, F. 'The Corticosteroid Receptor Hypothesis of Depression.' Neuropsychopharmacology 23 (2000).
Mayberg, H.S., Liotti, M., Brannan, S.K., McGinnis, S., Mahurin, R.K., Jerabek, P.A., Silva, J.A., Tekell, J.L., Martin, C.C., Lancaster, J.L., and Fox, P.T. 'Reciprocal Limbic-Cortical Function and Negative Mood: Converging PET Findings in Depression and Normal Sadness.' American Journal of Psychiatry 156 (1999).
Sheline, Y.I., Sanghavi, M., Mintun, M.A., and Gado, M.H. 'Depression Duration but not Age Predicts Hippocampal Volume Loss in Medically Healthy Women with Recurrent Major Depression.' Journal of Neuroscience 19 (1999).

TREATMENT OUTCOMES
Frank, E., and Thase, M.E. 'Natural History and Preventative Treatment of Recurrent Mood Disorders.' Annual Review of Medicine 50 (1999).
Wells, K.B., and Sherbourne, C.D., 'Functioning and Utility for Current Health of Patients with Depression or Chronic Medical Conditions in Managed, Primary Care Practices.' Archives of General Psychiatry 56 (1999).

Contents:
OVERVIEW
Sachs, G.S. 'A 25-Year-Old Woman with Bipolar Disorder.' Journal of the American Medical Association 285 (2001).

EPIDEMIOLOGY
Kessler, R.C., Rubinow, D.R., Holmes, C., Abelson, J.M., and Zhao, S. 'The Epidemiology of DSM-III-R Bipolar Disorder in a General Population Survey.' Psychological Medicine 27 (1997)

Genetics
Craddock, N. and Jones, I. 'Genetics of Bipolar Disorder.' Journal of Medical Genetics 36 (1999).

NATURAL HISTORY
Angst, J. and Sellaro, R. 'Historical Perspectives and Natural History of Bipolar Disorder.' Biological Psychiatry 48 (2000).
Kilzieh, N. and Akiskal, H.S. 'Rapid-Cycling Bipolar Disorder. An Overview of Research and Clinical Experience.' Psychiatric Clinics of North America 22 (1999).
Jamison, K.R. 'Suicide and Bipolar Disorder.' Journal of Clinical Psychiatry 61 (2000).
Sanchez, L., Hagino, O., Weller, R. 'Bipolarity in Children.' Psychiatric Clinics of North America 22 (1999).

EVOLUTION
Wilson, D.R. 'Evolutionary Epidemiology and Manic Depression.' British Journal of Medical Psychology 71 (1998).

NEUROBIOLOGY OF DISEASE
Blumberg, H.P., Stern, E., Martinez, D., Ricketts, S., de Asis, J., White, T., Epstein, J., McBride, P.A., Eidelberg, D., Kocsis, J.H., and Silbersweig, D.A. 'Increased Anterior Cingulate and Caudate Activity in Bipolar Mania.' Biological Psychiatry 48 (2000).
Leibenluft, E., Albert, P.S., Rosenthal, N.E., and Wehr, T.A. 'Relationship Between Sleep and Mood in Patients with Rapid-Cycling Bipolar Disorder.' Psychiatry Research 31 (1996)
Ikonomov, O.C. and Manji, H.K. 'Molecular Mechanisms Underlying Mood Stabilization in Manic-Depressive Illness: The Phenotype Challenge.' American Journal of Psychiatry 156 (1999)
Manji, H.K. and Lenox, R,H. 'Signaling: Cellular Insights into the Pathophysiology of Bipolar Disorder.' Biological Psychiatry 48 (2000)

TREATMENT AND TREATMENT MECHANISMS
Frank, E., Swartz, H.A., and Kupfer, D.J. 'Interpersonal and Social Rhythm Therapy: Managing the Chaos of Bipolar Disorder.' Biological Psychiatry 48 (2000).
Berridge, M.J., Downes, C.P., and Hanley, M.R. 'Neural and Developmental Actions of Lithium: A Unifying Hypothesis.' Cell 59 (1989)
Klein, P.S. and Melton, D.A. 'A Molecular Mechanism for the Effect of Lithium on Development.' Proceedings of the National Academy of Sciences of the USA 93 (1996).
Schou, M. 'Forty Years of Lithium Treatment.' Archives of General Psychiatry 54 (1997).

Contents:
OVERVIEW
McEwen, B.S., 'Allostasis and Allostatic Load: Implications for Neuropsychopharmacology.' Neuropsychopharmacology 22 (2000).

STRESS AND MEMORY
Cahill, L., Prins, B., Weber, M., and McGaugh, J.L. 'Beta-Adrenergic Activation and Memory for Emotional Events.' Nature 371 (1994).
de Quervain, D.J., Roozendaal, B., and McGaugh, J.L. 'Stress and Glucocorticoids Impair Retrieval of Long-Term Spatial Memory.' Nature 394 (1998).

STRESS, CHILD ABUSE, AND BRAIN DEVELOPMENT
Francis, D., Diorio, J., Liu, D., and Meaney, M.J., 'Nongenomic Transmission Across Generations of Maternal Behavior and Stress Responses in the Rat.' Science 286 (1999).
Heim, C., Newport, D.J., Heit, S., Graham, Y.P., Wilcox, M., Bonsall, R., Miller, A.H., and Nemeroff, C.B. 'Pituitary-Adrenal and Autonomic Responses to Stress in Women After Sexual and Physical Abuse in Childhood.' Journal of American Medical Association 284 (2000).
Maccari, S., Piazza, P.V., Kabbaj, M., Barbazanges, A., Simon, H., and Le Moal, M. 'Adoption Reverses the Long-Term Impairment in Glucocorticoid Feedback Induced by Prenatal Stress.' Journal of Neuroscience 15 (1995).

DEGENERATION AND REGENERATION
Gould, E., Tanapat, P., McEwen, B.S., Flugge, G., and Fuchs, E. 'Proliferation of Granule Cell Precursors in the Dentate Gyrus of Adult Monkeys Is Diminished by Stress.' Proceedings of the National Academy of Sciences of the USA 95 (1998).
Sapolsky, R.M., Uno, H., Rebert, C.S., and Finch, C.E. 'Hippocampal Damage Associated with Prolonged Glucocorticoid Exposure in Primates.' Journal of Neuroscience 10 (1990).
Sapolsky, R.M. 'Glucocorticoids and Hippocampal Atrophy in Neuropsychiatric Disorders.' Archive of General Psychiatry 57 (2000).

STRESS AND DRUG ADDICTION
Piazza, P.V. and Le Moal, M. 'The Role of Stress in Drug Self-Administration.' Trends in Pharmacological Sciences 19 (1998).

STRESS AND DEPRESSION
Wong, M.L., Kling, M.A., Munson, P.J., Listwak, S., Licinio, J., Prolo, P., Karp, B., McCutcheon, I.E., Geracioti, T.D., Jr., DeBellis, M.D., Rice, K.C., Goldstein, D.S., Veldhuis, J.D., Chrousos, G.P., Oldfield, E.H., McCann, S.M., and Gold, P.W. 'Pronounced and Sustained Central Hypernoradrenergic Function in Major Depression with Melancholic Features: Relation to Hypercortisolism and Corticotropin-Releasing Hormone.' Proceedings of the National Academy of Sciences of the USA 97 (2000).

STRESS AND HEALTH
Marmot, M.G., Smith, G.D., Stansfeld, S., Patel, C., North, F., Head, J., White, I., Brunner, E., and Feeney, A. 'Health Inequalities Among British Civil Servants: The Whitehall II Study.' Lancet 337 (1991).
Marmot, M.G., Bosma, H., Hemingway, H., Brunner, E., and Stansfeld, S. 'Contribution of Job Control and Other Risk Factors to Social Variations in Coronary Heart Disease Incidence.' Lancet 350 (1997).

INTERVENTIONS
Habib, K.E., Weld, K.P., Rice, K.C., Pushkas, J., Champoux, M., Listwak, S., Webster, E.L., Atkinson, A.J., Schulkin, J., Contoreggi, C., Chrousos, G.P., McCann, S.M., Suomi, S.J., Higley, J.D., and Gold, P.W. 'Oral Administration of a Corticotropin-Releasing Hormone Receptor Antagonist Significantly Attenuates Behavioral, Neuroendocrine, and Autonomic Responses to Stress in Primates.' Proceedings of the National Academy of Sciences of the USA 97 (2000).

Contents:
OVERVIEW
National Institutes of Health Concensus Development Conference Statement Diagnosis and Treatment of Attention Deficit Hyperactivity Disorder (1998).
Swanson, J.M., Sergeant, J.A., Taylor, E., Sonuga-Barke, E.J., Jensen, P.S,, and Cartwell, D.P., 'Attention-Deficit Hyperactivity Disorder and Hyperkinetic Disorder,' Lancet 351 (1998).

GENETICS
Cook, E.H. 'Genetics of Attention-Deficit Hyperactivity Disorder.' Mental Retardation and Developmental Disabilities Research Reviews 5 (1999).
Eaves, L.J., Silberg, J.L., Meyer, J.M., Maes, H.H., Simonoff, E., Pickles, A., Rutter, M., Neale, M.C., Reynolds, C.A., Erikson, M.T., Heath, A.C., Loeber, R., Truett, K.R., and Hewitt, J.K. 'Genetics and Developmental Psychopathology: 2. The Main Effects of Genes and Environment on Behavioral Problems in the Virginia Twin Study of Adolescent Behavioral Development.' Journal of Child Psychology and Psychiatry and Allied Disciplines 38 (1997).

NATURAL HISTORY
Biederman, J., Faraone, S., Milberger, S., Guite, J., Mick, E., Chen, L., Mennin, D., Marrs, A., Ouellette, C., Moore, P., Spencer, T., Norman, D., Wilens, T., Kraus, I., and Perrin, J. 'A Prospective 4-Year Follow-Up Study of Attention-Deficit Hyperactivity and Related Disorders.' Archives of General Psychiatry 53 (1996),
Faraone, S.V., Biederman, J., Spencer, T., Wilens, T., Seidman, L.J., Mick, E., and Doyle, A.E. 'Attention-Deficit/Hyperactivity Disorder in Adults: An Overview.' Biological Psychiatry 48 (2000).

EVOLUTION
Jensen, P.S., Mrazek, D., Knapp, P.K., Steinberg, L., Pfeffer, C., Schowalter, J., and Shapiro, T. 'Evolution and Revolution in Child Psychiatry: ADHD as a Disorder of Adaptation.' Journal of the American Academy of Child Adolescent Psychiatry 36 (1997).

NEUROBIOLOGY OF DISEASE
Castellanos, F.X., Giedd, J.N., Marsh, W.L., Hamburger, S.D., Vaituzis, A.C., Dickstein, D.P., Sarfatti, S.E., Vauss, Y.C., Snell, J.W., Lange, N., Kaysen, D., Krain, A.L., Ritchie, G.F., Rajapakse, J.C., and Rapoport, J.L. 'Quantitative Brain Magnetic Resonance Imaging in Attention-Deficit Hyperactivity Disorder.' Archive of General Psychiatry 53 (1996).
Peterson, B.S., Leckman, J.F., Tucker, D., Scahill, L., Staib, L., Zhang, H., King, R., Cohen, D.J., Gore, J.C., and Lombroso, P. 'Preliminary Findings of Antistreptococcal Antibody Titers and Basal Ganglia Volumes in Tic, Obsessive- Compulsive, and Attention Deficit/Hyperactivity Disorders.'Archives of General Psychiatry 57 (2000).
Swanson, J., Castellanos, F.X., Murias, M., LaHoste, G., and Kennedy, J. 'Cognitive Neuroscience of Attention Deficit Hyperactivity Disorder and Hyperkinetic Disorder.' Current Opinions in Neurobiology 8 (1998).
Zhuang, X., Oosting, R.S., Jones, S.R., Gainetdinov, R.R., Miller, G.W., Caron, M.G., and Hen, R. 'Hyperactivity and Impaired Response Habituation in Hyperdopaminergic Mice.' Proceedings of the National Academy of Sciences of the USA 98 (2001).

TREATMENT
MTA Cooperative Group. 'Moderators and Mediators of Treatment Response for Children with Attention-Deficit/Hyperactivity Disorder: The Multimodal Treatment Study of Children with Attention-Deficit/Hyperactivity Disorder.' Archives of General Psychiatry 56 (1999)
MTA Cooperative Group. 'A 14-Month Randomized Clinical Trial of Treatment Strategies for Attention-Deficit/Hyperactivity Disorder.' Archives of General Psychiatry 56 (1999).
Safer, D.J. and Malever, M. 'Stimulant Treatment in Maryland Public Schools.' Pediatrics 106 (2000).
Zito, J.M., Safer, D.J., dosReis, S., Gardner, J.F., Boles, M., and Lynch, F. 'Trends in the Prescribing of Psychotropic Medications to Preschoolers.' Journal of the American Medical Association 283 (2000).

Contents:
EPIDEMIOLOGY
Warner, L.A., Kessler, R.C., Hughes, M., Anthony, J.C., and Nelson, C.B. 'Prevalence and Correlates of Drug Use and Dependence in the United States. Results from the National Comorbidity Survey.' Archives of General Pychiatry 52 (1995).

GENETICS
Sigvardsson, S., Bohman, M., and Cloninger, C.R., 'Replication of the Stockholm Adoption Study of Alcoholism Confirmatory Cross-Fostering Analysis.' Archives of General Psychology 53 (1996).
Merikangas, K.R., Stolar, M., Stevens, D.E., Goulet, J., Preisig, M.A., Fenton, B., Zhang, H., O'Malley, S.S., and Rounsaville, B.J. 'Familial Transmission of Substance Use Disorders.' Archives of General Psychiatry 55 (1998).

NATURAL HISTORY
McLellan, A.T., Lewis, D.C., O'Brien, C.P., and Kleber, H.D. 'Drug Dependence, a Chronic Mental Illness: Implications for Treatment, Insurance, and Outcomes Evaluation.' Journal of the American Medical Association 284 (2000).
Schuckit, M.A., and Smith, T.L. 'An 8-Year Follow-Up of 450 Sons of Alcoholic and Control Subjects.' Archives of General Psychiatry 53 (1996).
Vaillant, G.E. 'A Long-Term Follow-Up of Male Alcohol Abuse.' Archives of General Psychiatry 53 (1996)

EVOLUTION
Nesse, Randolph M. 'An Evolutionary Perspective on Substance Abuse.' Ethology and Sociobiology 15 (1994).

NEUROBIOLOGY OF DISEASE
Berke, J.D., and Hyman, S.E. 'Addiction, Dopamine, and the Molecular Mechanisms of Memory.' Neuron 25 (2000).
O'Brien, Charles P., Childress, Anna Rose, Ehrman, Ronald, and Robbins, Steven J. 'Conditioning Factors in Drug Abuse: Can they Explain Compulsion?' Journal of Psychopharmacology 12 (1998).
Robinson, T.E. and Berridge, K.C. 'The Neural Basis of Drug Craving: An Incentive-Sensitization Theory of Addiction.' Brain Research Reviews 18 (1993).
Tiffany, Stephen T. 'A Cognitive Model of Drug Urges and Drug-Use Behavior: Role of Automatic and Nonautomatic Processes.' Psychological Review 97 (1990).
Volkow, N.D., Wang, G.J., Fowler, J.S., Logan, J., Gatley, S.J., Hitzemann, R., Chen, A.D., Dewey, S.L., and Pappas, N. 'Decreased Striatal Dopaminergic Responsiveness in Detoxified Cocaine-Dependent Subjects.' Nature 386 (1997).

Contents:
OVERVIEW
Allen, A. and Hollander, E. 'Body Dysmorphic Disorder.' Psychiatric Clinic of North America 23 (2000).
Groopman, J. 'The Doubting Disease: When is Obsession a Sickness?' The New Yorker (April 10, 2000).

EPIDEMIOLOGY
Horwath, E. and Weissman, M.M. 'The Epidemiology and Cross-National Presentation of Obsessive-Compulsive Disorder.' Psychiatric Clinic of North America 23 (2000).
Kadesjo, B. and Gillberg, C. 'Tourette's Disorder: Epidemiology and Comorbidity in Primary School Children.' Journal of the American Academy of Child and Adolescent Psychiatry 39 (2000).

GENETICS
Pauls, D.L., Raymond, C.L., Stevenson, J.M., and Leckman, J.F. 'A Family Study of Gilles de la Tourette Syndrome.' American Journal of Human Genetics 48 (1991).
Nestadt, G., Samuels, J., Riddle, M., Bienvenu, O.J. 3rd, Liang, K.Y., LaBuda, M., Walkup, J., Grados, M., and Hoehn-Saric, R. 'A Family Study of Obsessive-Compulsive Disorder.' Archives of General Psychiatry 57 (2000).

NATURAL HISTORY
Phillips, K.A., McElroy, S.L., Keck, P.E., Pope, H.G., and Hudson, J.I. 'Body Dysmorphic Disorder: 30 Cases of Imagined Ugliness.' American Journal of Psychiatry 2 (1993).
Riddle, M. 'Obsessive-Compulsive Disorder in Children and Adolescents.' British Journal of Psychiatry 35 (1998).
Skoog, G. and Skoog, I. 'A 40-Year Follow-Up of Patients with Obsessive-Compulsive Disorder.' Archives of General Psychiatry 56 (1999).

NEUROBIOLOGY OF DISEASE
Graybiel, A.M., and Rauch, S.L. 'Toward a Neurobiology of Obsessive-Compulsive Disorder.' Neuron 28 (2000).
Leckman, J.F., and Riddle, M.A., 'Tourette's Syndrome. When Habit-Forming Systems Form Habits of Their Own?' Neuron 28 (2000).
Saxena, S. and Rauch, S.L. 'Functional Neuroimaging and the Neuroanatomy of Obsessive-Compulsive Disorder.' Psychiatric Clinic of North America 23 (2000).
Swedo, S.E., Leonard, H.L., Garvey, M., Mittleman, B., Allen, A.J., Perlmutter, S., Lougee, L., Dow, S., Zamkoff, J., and Dubbert, B.K. 'Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections: Clinical Description of the First 50 Cases.' American Journal of Psychiatry 155 (1998).
Kurlan, R. 'Tourette's Syndrome and 'PANDAS': Will the Relation Bear Out? Pediatric Autoimmune Neuropsychiatric Disorders Associated with with Streptococcal Infection.' Neurology 50 (1998).
Peterson, B.S., Skudlarski, P., Anderson, A.W., Zhang, H., Gatenby, J.C., Lacadie, C.M., Leckman, J.F., and Gore, J.C. 'A Functional Magnetic Resonance Imaging Study of Tic Supression in Tourette's Syndrome.' Archives of General Psychiatry 55 (1998).
Szeszko, P.R., Robinson, D., Alvir, J.M., Bilder, R.M., Lencz, T., Ashtari, M., Wu, H., and Bogerts, B. 'Orbital Frontal and Amygdala Volume Reductions in Obsessive-Compulsive Disorder.' Archives of General Psychiatry 56 (1999).
Wolf, S.S., Jones, D.W., Knable, M.B., Gorey, J.G., Lee, K.S., Hyde, T.M., Coppola, R., and Weinberger, D.R. 'Tourette's Syndrome: Prediction of Phenotypic Variation in Monozygotic Twins by Caudate Nucleus D2 Receptor Binding.' Science 273 (1996).

Contents:
OVERVIEW
Lewis, D.A. and Lieberman, J.A. 'Catching Up on Schizophrenia, Natural History and Neurobiology.'Neuron 28 (2000).

EPIDEMIOLOGY
Kendler, K., Gallagher, T., Abelson, J., and Kessler, R.C. 'Lifetime Prevalence, Demographic Risk Factors, and Diagnostic Validity of Nonaffective Psychosis as Assessed in a US Community Sample.'Archives of General Psychiatry 53 (1996).
Mortensen, P.B., Pedersen, C.B., Westergaard, T., Wohlfahrt, J., Ewald, H., Mors, O., Andersen, P.K., and Melbye, M. 'Effects of Family History and Place and Season of Birth on the Risk of Schizophrenia.' New England Journal of Medicine 340 (1999).

GENETICS
Riley, B.P. and McGuffin, P. 'Linkage and Association Studies of Schizophrenia.' American Journal of Medical Genetics 97 (2000).
Baron, M. 'Genetics of Schizophrenia and the New Millenium: Progress and Pitfalls.' American Journal of Human Genetics 68 (2001).
Kety, S.S., Rosenthal, D., Wender, P.H., and Schulsinger, F. 'Mental Illness in the Biological and Adoptive Familes of Adopted Schizophrenics.' American Journal of Psychiatry 128 (1971)

NATURAL HISTORY
Bromet, E.J. and Fennig, S. 'Epidemiology and Natural History of Schizophrenia.' Biological Psychiatry 46 (1999).
Hearton, R.K., Gladsjo, J.A., Palmer, B.W., Kuck, J., Marcotte, T.D., and Jeste, D.V. 'Stability and Course of Neuropsychological Deficits in Schizophrenia.' Archives of General Psychiatry 58 (2001)
Robinson, D., Woerner, M.G., Alvir, J.M., Bilder, R., Goldman, R., Geisler, S., Koreen, A., Sheitman, B., Chakos, M., Mayerhoff, D., and Lieberman, J.A. 'Predictors of Relapse Following Response From a First Episode of Schizophrenia or Schizoaffective Disorder.' Archives of General Psychiatry 56 (1999).

NEUROBIOLOGY OF DISEASE
Akil, M., Pierri, J.N., Whitehead, R.E., Edgar, C.L., Mohila, C., Sampson, A.R, and Lewis, D.A. 'Lamina-Specific Alterations in the Dopamine Innervation of the Prefrontal Cortex in Schizophrenic Subjects.' American Journal of Psychiatry 156 (1999).
Arnold, S.E., Trojanowski, J.Q., Gur, R.E., Blackwell, P., Han, L.Y., and Choi, C. 'Absence of Neurodegeneration and Neural Injury in the Cerebral Cortex in a Sample of Elderly Patients with Schizophrenia.' Archives of General Psychiatry 55 (1998)
Braver, T.S., Barch, D.M., and Cohen, J.D., 'Cognition and Control in Schizophrenia: A Computational Model of Dopamine and Prefrontal Function.' Biological Psychiatry 46 (1999).
Glantz, L.A. and Lewis, D.A. 'Decreased Dendritic Spine Density on Prefrontal Cortical Pyramidal Neurons in Schizophrenia.' Archives of General Psychiatry 57 (2000).
Laruelle, M., Abi-Dargham, A., van Dyck, C.H., Gil, R., D'Souza, C.D., Erdos, J., McCance, E., Rosenblatt, W., Fingado, C., Zoghbi, S.S., Baldwin, R.M., Seibyl, J.P., Krystal, J.H., Charney, D.S., and Innis R.B., 'Single Photon Emission Computerized Tomography Imaging of Amphetamine-Induced Dopamine Release in Drug-Free Schizophrenic Subjects.' Proceedings of the National Academy of Sciences of the USA 93 (1996).
Okubo, Y., Suhara, T., Suzuki, K., Kobayashi, K., Inoue, O., Terasaki, O., Someya, Y., Sassa, T., Sudo, Y., Matsushima, E., Iyo, M., Tateno, Y., and Toru, M. 'Decreased Prefrontal Dopamine D1 Receptors in Schizophrenia Revealed by PET.' Nature 385 (1997).
Rajkowska, G., Selemon, L.D., and Goldman-Rakic, P.S. 'Neuronal and Glial Somal Size in the Prefrontal Cortex: A Postmortem Morphometric Study of Schizophrenia and Huntingdon Disease.' Archives of General Psychiatry 55 (1998).
Rapoport, J.L., Giedd, J.N., Blumenthal, J., Hamburger, S., Jeffries, N., Fernandez, T., Nicholson, R., Bedwell, J., Lenane, M., Zijdenbos, A., Paus, T., and Evans, A. 'Progressive Cortical Change During Adolescence in Childhood-Onset Schizophrenia. A Longitudinal Magnetic Resonance Imaging Study.' Archives of General Psychiatry 56 (1999).
Selemon, L.D. and Goldman-Rakic, P.S. 'The Reduced Neuropil Hypothesis: A Circuit Based Model of Schizophrenia.' Biological Psychiatry 45 (1999).
Suddath, R.L., Christison, G.W., Torrey, E.F., Casanova, M.F., and Weinberger, D.R. 'Anatomical Abnormalities in the Brains of Monozygotic Twins Discordant for Schizophrenia.' New England Journal of Medicine 322 (1990).
Weinberger, D.R. 'Implications of Normal Brain Development for the Pathogenesis of Schizophrenia.' Archives of General Psychiatry 44 (1987).

TREATMENT
Bustillo, J.R., Lauriello, J., Horan, W.P., and Keith, S.J. 'The Psychosocial Treatment of Schizophrenia: An Update.' American Journal of Psychiatry 158 (2001).
Castner, S.A., Williams, G.V., and Goldman-Rakic, P.S. 'Reversal of Antipsychotic-Induced Working Memory Deficits by Short-Term Dopamine D1 Receptor Stimulation.' Science 287 (2000).
Kapur, S., Zipursky, R.B., Remington, G. 'Clinical and Theoretical Implications of 5HT2 and D2 Receptor Occupancy of Clozapine, Risperidone, and Olanzapine in Schizophrenia.' American Journal of Psychiatry 156 (1999).
Lidow, M.S., Song, Z.-M., Castner, S.A., Allen, P.B., Greengard, P., and Goldman-Rakic, P.S. 'Antipsychotic Treatment Induces Alterations in Dendrite and Spine Associated Proteins in Dopamine-Rich Areas of the Primate Cerebral Cortex.' Biological Psychiatry 49 (2001).

This text offers a comprehensive introduction to molecular biology, genetics, and neurobiology relevant to psychiatry. Generously illustrated chapters are organized to be read at both an introductory and a more advanced level.

Both beginners and advanced professionals will benefit from this text's discussion of how psychotropic drugs work and how gene-environment interactions may contribute to the pathogenesis of psychiatric disorders. The authors demonstrate how molecular investigations in psychiatry will revolutionize the field by leading to improved diagnostic testing, to new and more effective treatments, and ultimately to the development of preventive measures for mental illness.