This book deals with the paradoxical role of autophagy in tumor suppression and tumor promotion in cancer cells. Autophagy plays opposing, context-dependent roles in tumors; accordingly, strategies based on inhibiting or stimulating autophagy could offer as potential cancer therapies. The book elucidates the physiological role of autophagy in modulating cancer metastasis, which is the primary cause of cancer-associated mortality. Further, it reviews its role in the differentiation, development, and activation of multiple immune cells, and its potential applications in tumor immunotherapy. In addition, it examines the effect of epigenetic modifications of autophagy-associated genes in regulating tumor growth and therapeutic response and summarizes autophagy's role in the development of resistance to a variety of anti-cancer drugs in cancer cells. In closing, it assesses autophagy as a potential therapeutic target for cancer treatment. Given its scope, the book offers a valuable asset for all oncologists and researchers who wish to understand the potential role of autophagy in tumor biology.

Key Points: Describes the different types of nanoparticles, characterization, and methods of preparation Covers novel fabrication, surface modification, and conjugation, to improve the drug-delivery pattern Discusses the leading nanoparticulate systems used for drug delivery or diagnosis Reviews industry-relevant methods for synthesis of a nanocarrier system Includes a focused section on the application of nanomaterials in cancer

This volume explores the complexities of governance, law, and politics in India's Scheduled Areas. The Scheduled Areas (SAs) are those parts of the country which have been identified by the Fifth and Sixth Schedule of the Constitution of India and are inhabited predominantly by tribal communities or Scheduled Tribes. SAs are often identified by their geographical isolation, primitive economies, and relatively egalitarian and closely knit society. Irrespective of the constitutional provision for governance and a mandate of devolution of power in terms of funds, functions and functionaries, the backwardness of these areas have remained a challenge. This volume attempts to explore the reasons behind the disregard for legal and institutional mechanism designed for the SAs. It examines the role of the state in the neoliberal era on fund allocation and utilisation, the governance of land and forest resources, and the ineffectiveness of the existing administrative structures and processes. It also looks into the interpretations of law by the judiciary while dealing with community rights vis-a-vis the state's prerogative of bringing development to the regions, and how development concerns are addressed in the name of 'good governance' by various stakeholders. Comprehensive and topical, this volume will be useful for scholars and researchers of political studies, development studies, developmental economics, sociology and social anthropology, and for policy makers.

This volume explores the complexities of governance, law, and politics in India's Scheduled Areas. The Scheduled Areas (SAs) are those parts of the country which have been identified by the Fifth and Sixth Schedule of the Constitution of India and are inhabited predominantly by tribal communities or Scheduled Tribes. SAs are often identified by their geographical isolation, primitive economies, and relatively egalitarian and closely knit society. Irrespective of the constitutional provision for governance and a mandate of devolution of power in terms of funds, functions and functionaries, the backwardness of these areas have remained a challenge. This volume attempts to explore the reasons behind the disregard for legal and institutional mechanism designed for the SAs. It examines the role of the state in the neoliberal era on fund allocation and utilisation, the governance of land and forest resources, and the ineffectiveness of the existing administrative structures and processes. It also looks into the interpretations of law by the judiciary while dealing with community rights vis-a-vis the state's prerogative of bringing development to the regions, and how development concerns are addressed in the name of 'good governance' by various stakeholders. Comprehensive and topical, this volume will be useful for scholars and researchers of political studies, development studies, developmental economics, sociology and social anthropology, and for policy makers.

This book is all about the nexus of "state, development intervention and the development community" where the main objective of the development intervention is to enhance the revenue of the State's economy. The institutional parameters are instrumental in this success. However, these mechanisms are limited to few stages of development, giving very little space to the development communities. This book is intended to present the contemporary research outcomes on the cross-cutting theme of development induced displacement. Please note: This title is co-published with Aakar Books, New Delhi. Taylor & Francis does not sell or distribute the Hardback in India, Pakistan, Nepal, Bhutan, Bangladesh, Maldives and Sri Lanka.

The present monograph on matrix partial orders, the first on this topic, makes a unique presentation of many partial orders on matrices that have fascinated mathematicians for their beauty and applied scientists for their wide-ranging application potential. Except for the Loewner order, the partial orders considered are relatively new and came into being in the late 1970s. After a detailed introduction to generalized inverses and decompositions, the three basic partial orders - namely, the minus, the sharp and the star - and the corresponding one-sided orders are presented using various generalized inverses. The authors then give a unified theory of all these partial orders as well as study the parallel sums and shorted matrices, the latter being studied at great length. Partial orders of modified matrices are a new addition. Finally, applications are given in statistics and electrical network theory. Deceased

This book deals with the paradoxical role of autophagy in tumor suppression and tumor promotion in cancer cells. Autophagy plays opposing, context-dependent roles in tumors; accordingly, strategies based on inhibiting or stimulating autophagy could offer as potential cancer therapies. The book elucidates the physiological role of autophagy in modulating cancer metastasis, which is the primary cause of cancer-associated mortality. Further, it reviews its role in the differentiation, development, and activation of multiple immune cells, and its potential applications in tumor immunotherapy. In addition, it examines the effect of epigenetic modifications of autophagy-associated genes in regulating tumor growth and therapeutic response and summarizes autophagy's role in the development of resistance to a variety of anti-cancer drugs in cancer cells. In closing, it assesses autophagy as a potential therapeutic target for cancer treatment. Given its scope, the book offers a valuable asset for all oncologists and researchers who wish to understand the potential role of autophagy in tumor biology.

This book systematically classifies the mathematical formalisms of computational models that are required for solving problems in mathematics, engineering and various other disciplines. It also provides numerical methods for solving these problems using suitable algorithms and for writing computer codes to find solutions. For discrete models, matrix algebra comes into play, while for continuum framework models, real and complex analysis is more suitable. The book clearly describes the method-algorithm-code approach for learning the techniques of scientific computation and how to arrive at accurate solutions by applying the procedures presented. It not only provides instructors with course material but also serves as a useful reference resource. Providing the detailed mathematical proofs behind the computational methods, this book appeals to undergraduate and graduate mathematics and engineering students. The computer codes have been written in the Fortran programming language, which is the traditional language for scientific computation. Fortran has a vast repository of source codes used in real-world applications and has continuously been upgraded in line with the computing capacity of the hardware. The language is fully backwards compatible with its earlier versions, facilitating integration with older source codes.

Textile Calculation: Fibre to Finished Garment provides detailed explanations of standard numerical calculations used at different stages of garment production, including spinning, weaving, processing, garmenting and testing. At every stage, from fiber production to garment manufacturing, textile production involves the selection of fibers or filaments, yarns, machines and process parameters. The calculations involved in this work relate to requirements of machines in the process line, estimations of process parameters, process characteristics, and machine efficiency, all of which must be objective and backed by sound theory. Drawing on extensive industry experience, this book gathers these numerical problems from across the supply chain to provide best practice and appropriate solutions. With its comprehensive coverage of all parts of the textile production cycle, this book is essential reading for those preparing to enter the textile industry, as well as an invaluable reference for professionals and researchers.

This book systematically classifies the mathematical formalisms of computational models that are required for solving problems in mathematics, engineering and various other disciplines. It also provides numerical methods for solving these problems using suitable algorithms and for writing computer codes to find solutions. For discrete models, matrix algebra comes into play, while for continuum framework models, real and complex analysis is more suitable. The book clearly describes the method-algorithm-code approach for learning the techniques of scientific computation and how to arrive at accurate solutions by applying the procedures presented. It not only provides instructors with course material but also serves as a useful reference resource. Providing the detailed mathematical proofs behind the computational methods, this book appeals to undergraduate and graduate mathematics and engineering students. The computer codes have been written in the Fortran programming language, which is the traditional language for scientific computation. Fortran has a vast repository of source codes used in real-world applications and has continuously been upgraded in line with the computing capacity of the hardware. The language is fully backwards compatible with its earlier versions, facilitating integration with older source codes.