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Rapid advances in nanotechnology have enabled the fabrication of
nanoparticles from various materials with different shapes, sizes,
and properties, and efforts are ongoing to exploit these materials
for practical clinical applications. Nanotechnology is particularly
relevant in the field of oncology, as the leaky and chaotic
vasculature of tumors-a hallmark of unrestrained growth-results in
the passive accumulation of nanoparticles within tumors. Cancer
Nanotechnology: Principles and Applications in Radiation Oncology
is a compilation of research in the arena of nanoparticles and
radiation oncology, which lies at the intersection of disciplines
as diverse as clinical radiation oncology, radiation physics and
biology, nanotechnology, materials science, and biomedical
engineering. The book provides a comprehensive, cross-disciplinary
survey of basic principles, research techniques, and outcomes with
the goals of eventual clinical translation. Coverage includes A
general introduction to fabrication, preferential tumor targeting,
and imaging of nanoparticles The specific applications of
nanomaterials in the realms of radiation therapy, hyperthermia,
thermal therapy, and normal tissue protection from radiation
exposure Outlooks for future research and clinical translation
including regulatory issues for ultimate use of nanomaterials in
humans Reflecting profound advances in the application of
nanotechnology to radiation oncology, this comprehensive volume
demonstrates how the unique physicochemical properties of
nanoparticles lead to novel strategies for cancer treatment and
detection. Along with various computational and experimental
techniques, each chapter highlights the most promising approaches
to the use of nanoparticles for radiation response modulation.
The book Heat Shock Protein-Based Therapies provides the most
up-to-date review on new heat shock protein-based mechanisms used
in the therapy and treatment of various human disorders and
diseases, including cancer, muscular atrophy, neurodegenerative
disorders (Alzheimer's Disease, Multiple Sclerosis) and infectious
diseases (HIV, periodontal disease). Written by leaders in the
field of heat shock protein research, the chapters systematically
and in a step wise fashion takes the reader through the fascinating
sequence of events by which mechanisms dependent on heat shock
proteins are targeted. The chapters also provide answers as to HSP
biological significance to the host. This book is a must read for
graduate and postgraduates in the field of Drug Development,
Biotechnology, Pharmaceutical Industry, Phytomedicine, Biology
(plant and mammal), Biochemistry (pro- and eukaryotic), Oncology,
Immunology, Microbiology, Exercise Medicine, Physiology,
Inflammatory diseases, Autoimmunity, Pharmacology and Pathology.
The book Heat Shock Protein-Based Therapies provides the most
up-to-date review on new heat shock protein-based mechanisms used
in the therapy and treatment of various human disorders and
diseases, including cancer, muscular atrophy, neurodegenerative
disorders (Alzheimer's Disease, Multiple Sclerosis) and infectious
diseases (HIV, periodontal disease). Written by leaders in the
field of heat shock protein research, the chapters systematically
and in a step wise fashion takes the reader through the fascinating
sequence of events by which mechanisms dependent on heat shock
proteins are targeted. The chapters also provide answers as to HSP
biological significance to the host. This book is a must read for
graduate and postgraduates in the field of Drug Development,
Biotechnology, Pharmaceutical Industry, Phytomedicine, Biology
(plant and mammal), Biochemistry (pro- and eukaryotic), Oncology,
Immunology, Microbiology, Exercise Medicine, Physiology,
Inflammatory diseases, Autoimmunity, Pharmacology and Pathology.
Rapid advances in nanotechnology have enabled the fabrication of
nanoparticles from various materials with different shapes, sizes,
and properties, and efforts are ongoing to exploit these materials
for practical clinical applications. Nanotechnology is particularly
relevant in the field of oncology, as the leaky and chaotic
vasculature of tumors-a hallmark of unrestrained growth-results in
the passive accumulation of nanoparticles within tumors. Cancer
Nanotechnology: Principles and Applications in Radiation Oncology
is a compilation of research in the arena of nanoparticles and
radiation oncology, which lies at the intersection of disciplines
as diverse as clinical radiation oncology, radiation physics and
biology, nanotechnology, materials science, and biomedical
engineering. The book provides a comprehensive, cross-disciplinary
survey of basic principles, research techniques, and outcomes with
the goals of eventual clinical translation. Coverage includes A
general introduction to fabrication, preferential tumor targeting,
and imaging of nanoparticles The specific applications of
nanomaterials in the realms of radiation therapy, hyperthermia,
thermal therapy, and normal tissue protection from radiation
exposure Outlooks for future research and clinical translation
including regulatory issues for ultimate use of nanomaterials in
humans Reflecting profound advances in the application of
nanotechnology to radiation oncology, this comprehensive volume
demonstrates how the unique physicochemical properties of
nanoparticles lead to novel strategies for cancer treatment and
detection. Along with various computational and experimental
techniques, each chapter highlights the most promising approaches
to the use of nanoparticles for radiation response modulation.
Oxidative stress and inflammation are among the most important
factors of disease. Chronic infections, obesity, alcohol and
tobacco usage, radiation, environmental pollutants, and
high-calorie diets have been recognized as major risk factors for a
variety of chronic diseases from cancer to metabolic diseases. All
these risk factors are linked to chronic diseases through
inflammation. While short-term, acute inflammation generated by the
immune system serves a therapeutic role, chronic low-level
inflammation that may persist "silently" for decades is responsible
for chronic diseases. Inflammation, Lifestyle, and Chronic
Diseases: The Silent Link describes the role of dysregulated
inflammation in persistent and recurring diseases. It investigates
links to lifestyle and presents research on how the suppression of
proinflammatory pathways may provide opportunities for both
prevention and treatment of chronic diseases. The book covers
neurodegenerative diseases, pulmonary diseases, asthma, rheumatic
and arthritic diseases, skin disease, heart disease, chronic
wounds, infectious disease, neuropsychiatric disorders such as
depression, gastrointestinal diseases, insulin resistance, and
cancer, many of which are also diseases of old age. For each
chronic disease, contributors review the clinical and scientific
literature and examine current and potential therapies, including
conventional pharmacotherapies as well as natural products. Noting
that the long-term use of steroids and nonsteroidal
anti-inflammatory drugs (NSAIDs) can cause adverse side effects,
many of the chapters address the role of dietary agents such as
fruits, vegetables, legumes, pulses, nuts, and spices as ideal
anti-inflammatory agents that can be consumed regularly. The book
also suggests directions for further research. Clinical and science
researchers, students, and health professionals interested in the
link between inflammation, lifestyle, and chronic diseases will
find this an informative resource.
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