Oxidative stress and inflammation are among the most important
factors of disease. Chronic infections, obesity, alcohol and
tobacco usage, radiation, environmental pollutants, and
high-calorie diets have been recognized as major risk factors for a
variety of chronic diseases from cancer to metabolic diseases. All
these risk factors are linked to chronic diseases through
inflammation. While short-term, acute inflammation generated by the
immune system serves a therapeutic role, chronic low-level
inflammation that may persist "silently" for decades is responsible
for chronic diseases. Inflammation, Lifestyle, and Chronic
Diseases: The Silent Link describes the role of dysregulated
inflammation in persistent and recurring diseases. It investigates
links to lifestyle and presents research on how the suppression of
proinflammatory pathways may provide opportunities for both
prevention and treatment of chronic diseases. The book covers
neurodegenerative diseases, pulmonary diseases, asthma, rheumatic
and arthritic diseases, skin disease, heart disease, chronic
wounds, infectious disease, neuropsychiatric disorders such as
depression, gastrointestinal diseases, insulin resistance, and
cancer, many of which are also diseases of old age. For each
chronic disease, contributors review the clinical and scientific
literature and examine current and potential therapies, including
conventional pharmacotherapies as well as natural products. Noting
that the long-term use of steroids and nonsteroidal
anti-inflammatory drugs (NSAIDs) can cause adverse side effects,
many of the chapters address the role of dietary agents such as
fruits, vegetables, legumes, pulses, nuts, and spices as ideal
anti-inflammatory agents that can be consumed regularly. The book
also suggests directions for further research. Clinical and science
researchers, students, and health professionals interested in the
link between inflammation, lifestyle, and chronic diseases will
find this an informative resource.
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