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Computational Sciences (Hardcover)
Ponnadurai Ramasami; Contributions by Mauricio Alcolea Palafox, Bandyopadhyay Akra, Sachin Bhalekar, Sutapa Biswas Majee, …
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R4,393
Discovery Miles 43 930
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Ships in 12 - 17 working days
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Eleven carefully selected, peer-reviewed contributions from the
Virtual Conference on Computational Science (VCCS-2016) are
featured in this edited book of proceedings. VCCS-2016, an annual
meeting, was held online from 1st to 31st August 2016. The theme of
the conference was "Computational Thinking for the Advancement of
Society" and it matched the paradigm shift in the way we think.
VCCS-2016 was attended by 100 participants from 20 countries. The
chapters reflect a wide range of fundamental and applied research
applying computational methods.
Bioadhesive formulations have a wide scope of application for both
systemic and local effects of the drug. The oral transmucosal drug
delivery bypasses liver and avoids pre-systemic elimination. The
strategies to overcome such obstacles include the employment of new
materials that, possibly, combine mucoadhesive and penetration
enhancer properties and the design of novel drug delivery systems
which, besides improving patient compliance, favor a more intimate
contact of the drug with the absorption mucosa. Cellulose
derivatives like HPMC is having good mucoadhesive property however
it's potential can be increased by inclusion of plant derived gum
like gum karaya. Diclofenac is a non-steroidal anti-inflammatory
drug (NSAID) with pain relieving properties. It is used to treat
many painful conditions, inflammation, swelling, and /or stiffness
caused by several conditions and acute postoperative pain. One form
of diclofenac, the potassium salt, is more effective at the same
dose than the other form of diclofenac, the sodium salt. In view of
first pass effect it has been selected as model drug for the study.
Tailoring or modulation of drug release from delivery systems
comprises a major area of research in pharmaceutical field where
the primary objective is to either sustain drug release or to
design orodispersible tablets. This objective can be successfully
achieved by use of a class of natural excipients - gums and
mucilages. These polysaccharidic plant-derived biopolymers because
of their unique swellability in aqueous medium can exert a
retardant effect on drug release or can act as superdisintegrant,
depending on the concentration used in the formulation. Mechanism
of drug release from hydrophilic matrices consisting of gums and
mucilages is based on solvent penetration-induced polymer
relaxation, diffusion of entrapped drug followed by degradation or
erosion of the matrix. The degree and time-scale of swelling
contributes significantly to the kinetics of drug release. Drug
diffusion from polysaccharidic hydrogel may be of either Fickian,
Case II or anomalous transport type. The book has been designed to
highlight on the bifunctional aspect of the natural gums primarily
because of their concentration-dependent effect on drug release and
their high degree of swellability.
The duration of diabetes, and fasting blood sugar values were
significantly higher in patients with diabetes with severe CAN.
Prolongation of QTC interval correlates well with degree of cardiac
autonomic neuropathy in diabetics. QTC prolongation may be
considered as pointer towards diabetic cardiac autonomic neuropathy
in the busy outpatient setting where it is not possible to perform
the conventional battery of tests. Recognition of QTC prolongation
may help identify diabetics with a high risk of sudden cardiac
death. Trying to manage diabetes is hard because if you don't,
there are consequences you'll have to deal with later in life."
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