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This volume collects the invited lectures and some selected
contributions presented at the 5th International Meeting on
Clinical Pharmacology in Psychiatry, which was held 26-30 June 1988
at the University of Troms0, Norway. The 24 h of daylight at the
northernmost university in the world al lowed for long, pleasant
and productive sessions. The title of the conference as well as a
number of the topics covered represent a continuation of four
previous conferences, the first held in Chicago in 1979 and
organized by the late Earl U sdin and colleagues. The earlier
conferences have been documented in Clinical Pharmacology in
Psychiatry, edited by E. Usdin (Elsevier, New York, 1981), Clinical
Pharmacology in Psychiatry. Neuroleptic and Antidepressant
Research, edited by E. Usdin, S. G. Dahl, L. F. Gram and o.
Lingjrerde (Macmillan Publishers Ltd., London, 1981), Clinical
Pharmacology in Psychiatry. Bridging the Experimental-Therapeutic
Gap, edited by LF. Gram, E. Usdin, S.G. Dahl, P. Kragh-Sorensen, P.
L. Morselli and F. Sjoqvist (Macmillan Publishers Ltd., London,
1983), and Clinical Pharmacology in Psychiatry. Selectivity in
Psychotropic Drug Action - Promises or Problems? edited by S. G.
Dahl, L.F. Gram, S.M. Paul and W.Z. Potter (Psychopharmacology
Series 3, Springer, Heidelberg, 1987)."
The Fourth International Meeting on Clinical Pharmacology in
Psychiatry was held in Bethesda, Maryland on 5-8 September 1985 and
was dedicated to the memory of Dr. Earl Usdin. Earl was one of the
organizers of the three previous meetings held in Chicago (1979),
Troms0 (1980), and Odense (1982). During the organization of the
fourth meeting Earl became ill and had to relinquish his role as
one of the principal organizers. It is safe to conclude that there
was no better, or more professional, or more efficient an organizer
of scientific meetings in the field of neuropharmacology and
psychiatry than Earl U sdin, and it was quite a task for the
remaining organizers to fill the void left when he withdrew from
this one. Those of us who have organized previous meetings with
Earl were struck by how much more difficult our work became without
him. This obviously speaks well for his subtle (and at times not so
subtle) organizational skills. Nevertheless, in Earl's memory the
organizers proceeded to invite a group of internationally renowned
neuropsychopharmacologists to address the problem of selectivity in
psychotropic drug action and to try to reconcile the amazing
advances in basic preclinical neuropsychopharmacology with the
problem of clinical specificity encountered by the psychiatrist.
This book contains the papers from invited lecturers as well as
selected contributions presented at the 6th International Meeting
on Clinical Pharmacology in Psychiatry (I.M.C.P.P.) held in Geneva,
Switzerland, 5-7 June 1991. At this meeting the basic theme of the
previous meetings in this series (Chicago 1979, Troms0 1980, Odense
1982, Bethesda 1985, Troms0 1988) was continued, namely, to bridge
the gap between experimental development and clinical reality in
psychopharmacology. After more than 25 years of intensive research
in biological psychiatry, basic understanding of the biological
mechanisms underlying major psychiatric diseases has advanced
significantly but is still far from complete. Likewise, the
hypotheses underlying the development of new psychotropics have
been refined and produced a wide spectrum of novel, yet designed
compounds. The crucial condition for all progress in this field is
reliable, informative clinical testing of new compounds. It is our
hope that this book, as a continuation of the earlier publications
in this series, provides further evidence of the ongoing
interaction between preclinical and clinical scientists, who only
together can assure progress in this exciting area of research and
clinical practice.
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