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There is no doubt that the field of artificial membrane transport
using synthetic ionophores has advanced remarkably in the past 15
years due primarily to the synthesis of new ionophores. Even though
the theoretical framework substantially predated this activity, the
merging of theory with transport experiment has often been sketchy.
The purpose of this outline has been to examine key examples to
illustrate the underlying principles and to suggest how
experimental variables dominate the results obtained. To a very
good approximation the assumption of a "diffusion" regime is often
justified, is easily confirmed experimentally and provides a clear
framework for exploitation of the inherent selectivity of a given
ionophore. Thus for synthetic chemists who wish a "quick and nasty"
experiment to examine the question of selectivity, the recipe is
clear: a mixture containing all ions of interest in a standard
experiment for each ligand of interest using a moderately stirred
(100-200 rpm) cell and analysis of the mixture produced on the OUT
side of the cell at a fixed, small extent of transport. Together
with duplicates and controls, this modest set of experiments will
place the results on an unambiguous footing from which clear
conclusions about each ionophore's characteristics are readily
obtained. For those with more detailed interests in the transport
process the demands are correspondingly higher.
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Clathrate Compounds, Molecular Inclusion Phenomena, and Cyclodextrins - Proceedings of the Third International Symposium on Clathrate Compounds and Molecular Inclusion Phenomena and the Second International Symposium on Cyclodextrins, Tokyo, Japan, July 23-27, 1984 (Paperback, Softcover reprint of the original 1st ed. 1984)
J.L. Atwood, J.E. Davies, T. Osa
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R4,753
Discovery Miles 47 530
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Ships in 10 - 15 working days
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The Joint Meeting comprisIng the 3rd International Symposium on
Clathrate Compounds and Molecular Inclusion Phenomena and the 2nd
International Symposium on Cyclodextrins was held on 23-27 July,
1984, in Tokyo, Japan. It was organized by the Japan Association
for Inclusion Chemistry together with the International
Organization Committee, with the auspices of sixteen societies and
associations in Japan. This event was the first joint meeting with
the hope of unifying the above two symposia. The program of the
symposium consisted of 142 papers, including 14 invited papers. The
invited papers and some selected topics were presented verbally,
and all the other 118 papers were displayed in poster sessions. The
symposium was held at Hoshi University in Tokyo. Due to the
multidisciplinary nature of the subjects treated, the scope and
subjects were grouped into two parts. In the first group, the
chemistry of cyclodextrins, synthetic organic hosts, inorganic and
metal complex hosts and layered hosts were treated. In the second
group applications in various fields, biomimetic aspects,
physicochemical aspects, selectivity, stereo-specificity and other
aspects were discussed. The scientific sessions were carried out in
a really vivid atmosphere. The number of participants viz 50 from
19 overseas countries and 253 domestic partici pants exceeded our
expectation."
There is no doubt that the field of artificial membrane transport
using synthetic ionophores has advanced remarkably in the past 15
years due primarily to the synthesis of new ionophores. Even though
the theoretical framework substantially predated this activity, the
merging of theory with transport experiment has often been sketchy.
The purpose of this outline has been to examine key examples to
illustrate the underlying principles and to suggest how
experimental variables dominate the results obtained. To a very
good approximation the assumption of a "diffusion" regime is often
justified, is easily confirmed experimentally and provides a clear
framework for exploitation of the inherent selectivity of a given
ionophore. Thus for synthetic chemists who wish a "quick and nasty"
experiment to examine the question of selectivity, the recipe is
clear: a mixture containing all ions of interest in a standard
experiment for each ligand of interest using a moderately stirred
(100-200 rpm) cell and analysis of the mixture produced on the OUT
side of the cell at a fixed, small extent of transport. Together
with duplicates and controls, this modest set of experiments will
place the results on an unambiguous footing from which clear
conclusions about each ionophore's characteristics are readily
obtained. For those with more detailed interests in the transport
process the demands are correspondingly higher.
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