China and Taiwan are two of the fastest growing economies of the newly industrialized countries. Much of this growth has come from multinational companies; partly, it has often been assumed, because the region provides a "pollution haven" multinationals would not enjoy elsewhere. Tsai tests this hypothesis with detailed empirical research. Focusing on the chemical sector, he compares the policies and behavior of three multinational corporations with three large local firms. His research shows that multinationals have created more enviromentallhy sound operations through local companies.

China and Taiwan are two of the fastest growing economies of the newly industrialized countries. Much of their growth has come from multinational companies; partly, it has often been assumed, because the region provides a 'pollution haven' which the multinationals would not enjoy elsewhere. Corporate Environmentalism in China and Taiwan tests this hypothesis with detailed empirical research. Focusing on the chemical sector, the author compares the policies and behaviour of three multinational corporations with three large, local firms. The research shows that in fact the multinational companies have out-performed local companies in the phenomenon of 'greening'.

The purpose of this research monograph is to utilize algebraic and systems theory for the structure analysis and design of multivariable control systems described by state-space representations and matrix fraction descriptions. A unified approach characterizing the dynamics of a system through the formulation of the characteristic -matrix of the system is presented. The latent structures, solvents, divisors, and spectral factors of the non-singular characteristic -matrix and their relationships with the respesctive counterparts of the state-space representations are explored. Applications in model reduction, pole assignment design, modal control design for multivariable systems, parallel realizations and cascade realizations of multiport networks are illustrated. Computational algorithms and illustrative numerical examples are presented throughout the monograph. The reader is assumed to have a graduate level background in modern control theory.

Discover new and emerging applications for microdialysis in drug evaluation

Microdialysis is a highly valuable sampling tool that can be used in vivo to measure free, unbound analyte concentrations located in interstitial and extracellular spaces. This book explores the full range of clinical applications for microdialysis, focusing on its use in different organ and tissue systems for pharmacokinetic and pharmacodynamic studies. Readers gain a full understanding of the underlying science of microdialysis, current techniques and practices, as well as its many applications in pharmaceutical research.

Applications of Microdialysis in Pharmaceutical Science starts with an introduction to basic principles and then covers analytical considerations, pharmacodynamic and pharmacokinetic studies, clinical aspects, and special applications. Topics include:

Role of microdialysis in drug development, including crucial sampling considerations and applications for nervous system diseases

Continuous measurement of glucose concentrations in diabetics

Applications for clinical evaluation and basic research on organ systems, including monitoring exogenous and endogenous compounds in the lungs

Pharmacokinetic and pharmacodynamic evaluation of anticancer drugs

Comparison of microdialysis with imaging approaches to evaluate in vivo drug distribution

Special applications of microdialysis in studies of cell culture assays, drug-drug interactions, and environmental monitoring

Throughout the book, readers will find simple models that clarify complex concepts and easy-to-follow examples that guide them through key applications in pharmaceutical research. In short, this book enables pharmaceutical researchers to take full advantage of microdialysis techniques for the preclinical and clinical evaluation of drugs and much more.