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Readers will be aware that asthma is one of the commonest chronic
diseases of industrialised societies, with an increase in morbidity
and mortality, despite the availability of a range of different
drugs. In an effort to improve the treatment of asthmatic patients,
international guidelines have recently recognised asthma as an
inflammatory disease, and there has been a change in emphasis from
bronchodilator drugs towards earlier use of anti-inflammatory
treatments. This volume brings together the latest developments in
our understanding of the mechanisms of asthma, considers the safety
ofbeta-adrenoceptor agonists, and explores latest developments in
the use of phosphodiesterase (PDE) inhibitors in asthma therapy.
The second international conference on "New Drugs in Allergy and
Asthma" was held in Davos on 8-10 July 1992. There were six
sessions with specialist chairmen: PDE isoenzymes (c. D.
Nicholson), atopy and the environment (8. Villiger), adhesion
molecules (R. H. Gundel), cytokines (M. Baggiolini), airway
hyperreactivity (S. Makino) and neurotransmitters (J. G.
Widdicombe). The success of the meeting was ensured by a high
standard of presentation, with extensive reference to recent
experimental data. The chairmen were instrumental in fostering
stimulating discussion periods, that considerably enlivened the
meeting. Particular thanks are due to the Swiss Institute for
Asthma and Allergy Research (SIAF) and also to the e1inicians of
Davos for their assistance and hospitality. In addition, a number
of pharmaceutical companies were kind enough to support this
meeting that was devoted to academic aspects of drug discovery.
John Morley FRCPath.
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