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This book serves as an introduction to targeted genome editing,
beginning with the background of this rapidly developing field and
methods for generation of engineered nucleases. Applications of
genome editing tools are then described in detail, in iPS cells and
diverse organisms such as mice, rats, marine invertebrates, fish,
frogs, and plants. Tools that are mentioned include zinc finger
nucleases (ZFNs), transcription activator-like effector nucleases
(TALENs), and CRISPR/Cas9, all of which have received much
attention in recent years as breakthrough technologies. Genome
editing with engineered nucleases allows us to precisely change the
target genome of living cells and is a powerful way to control
functional genes. It is feasible in almost all organisms ranging
from bacteria to plants and animals, as well as in cultured cells
such as ES and iPS cells. Various genome modifications have proven
successful, including gene knockout and knock-in experiments with
targeting vectors and chromosomal editing. Genome editing
technologies hold great promise for the future, for example in
biomedical research, clinical medicine, and generation of crops and
livestock with desirable traits. A wide range of readers will find
this book interesting, and with its focus on applications in a
variety of organisms and cells, the book will be valuable for life
scientists in all fields.
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