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Development of a pharmaceutical product is essentially a technique
where in physicochemical properties of an active ingredients,
excipients and manufacturing process are manipulated to achieve
desired qualities in pharmaceutical finished dosage form. Certain
goals such as product specifications, ease of manufacturing cost
etc are defined for a dosage form prior to initiating the
development work. The traditional trial and error approach may be
less dependable and more time consuming and often provides an
approximately or marginally acceptable formulation and process. In
today's market optimization requires skill in understanding
physicochemical properties of their materials and effect on the
process identification and independent (cause) and
dependent(effective) variables and understanding of expected
relationship between cause and effect is crucial to the success of
this approach.
The use of polymeric matrix devices to control the release of
variety of therapeutic agents has become increasingly important in
development of the modified release dosage forms. The device may be
a swellable, hydrophilic monolithic systems, an erosion controlled
monolithic system or a non erodible system. The initial burst
release of 5-Fluoruracil from such matrix tablet surface can be
controlled by compression coating technology. Appropriate
combination of hydrophilic polymer in upper and lower layer of
tablet can govern the release of 5-fluoruracil as well as lag time
to deliver it in effective concentration to the colon with reduced
toxicity. The lag time can be controlled by appropriate combination
of polymer and excipients in coating layer. The release mechanism
of 5-fluoruracil from the compression coated tablets was controlled
by the rate of water uptake into the core tablet, which in turn was
dependent upon the channeling agent used, the type and
concentration of polymer. The hydration and swelling of these
polymers results in the formation of gel which control the release
of 5-fluoruracil from tablet.
Various approaches have been paused to increase the duration of
oral dosage form in the stomach, including floating systems,
swelling and expanding system, modified shape system, high density
systems and other delayed gastric emptying devices. (Magnetic
systems, Super porous -biodegradable hydrogel systems).
Hydrodynamically balanced systems (HBS) -incorporated buoyant
materials enable the device to float. Raft systems incorporate
alginate gels - these have a carbonate component and, upon reaction
with gastric acid, bubbles form in the gel, enabling floating.
Swelling type of dosage form are such that after swelling, this
product swell to extent that prevent their exit from the stomach
through the pylorus. As, a result, the dosage form retained in the
stomach for a longer period of time. These systems may be referred
to as a "Plug type system," since they exhibit tendency to remain
logged in the pyloric sphincters.
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