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Searching for a job has been an everyday affair in both modern and
past societies, and employment a concern for both individuals and
institutions. The case studies in this volume investigate job
search and placement practices in European countries, Australia,
and India in the nineteenth and twentieth centuries. The
contributors explore how looking for work becomes a means by which
participants (individuals, placement agents, trade unions,
municipalities, administrations, state authorities, and schools)
articulated specific interests, perspectives, and agendas. Taking
an exploratory approach, the chapters illustrate different
approaches to the history of employment and job searching, ranging
from organizational and regulatory histories to the analysis of
practices and autobiographical accounts. In the process, they
uncover the interrelations of search practices and attempts to
arrange placement services.
150 years after the first description of the clinical picture of
"white blood" and the introduction of the term "leukemia" by R.
Virchow it appears, that the leukemias, and the acute leukemias in
particular, serve as an impressive example for the major
improvements that have been achieved in the treatment but also in
the understand ing of the biology of malignant dis orders. The
international symposia "Acute Leukemia" which are held at Munster
since 1986 have developed into an interna tional forum to review
the current progress and the future perspectives of leukemia
research and therapy at a high scientific and clinicallevel. Since
the possibility for active participation in these symposia is
somewhat restricted we are glad to have the opportunity to extend
the information that was presented at the symposium "Acute
Leukemias V - Experimental Approaches and Management of Refractory
Disease" which was held from February 27 to March 2, 1994 to a
broader audience of basic scientists and clinicians. This meeting
was especiaIly designed to discuss experimen tal approaches and the
management of refractory disease which allows to evaluate new
experimental therapies on the basis of preclinical studies."
The 6th volume of the book series Acute Leukemias presents both
therapeutic and prognostic updates of the most recent results of
major multicenter clinical trials. Additional chapters report on
new trends in leucemia cell biology, the monitoring of minimal
residual disease and secondary leucemias as well as new
antileucemic drugs, antimicrobial strategies and the use of
cytocines. Acute Leukemias VI provides a new update on the rapid
progress being made internationally concerning leucemic diseases.
Acute leukemia a quite homogenous disease failed to break through
the sound barriere of when untreated reveals a substantial hetero
unsatisfactory cure rates even in special sub geneity in its
response to therapy. While cure groups. While new protocols
including more is achieved in a certain proportion of pa effective
supportive care show some increase tients other cases prove to be
highly resis in the initial response rates and certain im tant. The
curability is superior in acute provements in the long-term
results, no ben lymphoblastic (ALL) than in acute myeloid eficial
effect on the relapse rate during the (AML) leukemia and - within
both type- first 1 Y2 years emerged from any of these higher in
children as compared to adults. regimens. Thus, high chances for
cure are The two age groups and cell types can be presently
restricted to children with ALL further subdivided into prognostic
groups and to lesser proportions children with by special
diagnostic features. Thus, in AML and adults with ALL and AML.
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Tumor Aneuploidy (Paperback)
Thomas Buchner; Assisted by Michael Andreeff, B. Barlogie; Edited by Clara D. Bloomfield, Wolfgang Hiddemann; Assisted by …
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Discovery Miles 15 260
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Chromosome abnormalities of cancer cells have been recognized for a
long time, and have generally proven to be a highly specific marker
ofmalignancy. The contri- butions collected in this book, "Tumor
Aneuploidy", cover several major aspects of present knowledge
conceming the occurrence and clinical significance of chromo- some
abnormalities as delineated by karyotype analyses or measurements
of the cellular DNA content. Certain non-random clonal chromosome
losses, deletions and translocations ap- pear to represent primary
genetic lesions of malignancies and reflect their clonal origin.
Secondary intraneoplastic genetic evolution is suggested by major
clonal ab- normalities of chromosome number and cellular DNA
content. Both types of ge- netic changes have been reaching great
relevance in cancer medicine, today. Although the Philadelphia
chromosome was first discovered in chronic myelo- cytic leukemia
(CML), by Nowell and Hungerford in 1960, new banding techniques
developed in the 1970's were needed to identity this abnormality as
a translocation between chromosomes 9 and 22 (t(9; 22)). Soon
thereafter, further non-random translocations were detected and
attributed to special diseases like t(8; 21) and t(15; 17) to acute
myeloid leukemias (AML) and t(9; 22), t(4; 11), t(8; 14) to acute
lymphoblastic leukemia (ALL).
Das Buch berichtet tiber das 1. Hauptthema der 28. Jahrestagung der
Deutschen Gesellschaft flir Hamatologie und Onkologie 1983 in
Mtinster. Der Zeitpunkt flir eine neue Bestandsaufnahme der
Therapie der akuten Leukamien ist gtinstig, da ei- nige, in den
70er Jahren konzipierte Fortschritte inzwischen auf ausreichender
Beobachtungszeit der behandelten Patienten beruhen. Die hier
mitgeteilten und daB das diskutierten Ergebnisse aus maBgeblichen
Zentren und Studien zeigen, Nahziel der kompletten Remission heute
bei der Mehrzahl der Patienten zu er- reichen ist und daB dieses
das Erreichen des Femziels Heilung flir einen Teil der Pa- tienten
bedeutet. Dieser Teil erscheint bei lymphatischem Zelltyp groBer
als bei myeloischem und innerhalb der Zelltypen bei Kindem groBer
als bei Erwachsenen. Auf dem Weg bis hierher findet sich zunachst
der therapeutische Durchbruch bei der Akuten Lymphatischen Leukamie
des Kindes mittels Kombinations-Chemo- therapie und
prophylaktischer antileukamischer Behandlung des Zentralnervensy-
stems. Ihm folgten zahlreiche kleine Schritte der besseren Nutzung
der verfligba- ren Chemotherapie durch ihre Intensivierung und
Risiko-Anpassung. Parallel hier- zu wurde die
Knochenmark-Transplantation hoch entwickelt. Die Immuntherapie fand
konsequentere Formen. Wesentliche Altemativen und Modifikationen
der Therapie akuter Leukamien befinden sich noch in Erprobung durch
vergleichende Studien. Zuktinftiger Fortschritt ist zu sehen in
einer Senkung der Frtihletalitat durch rechtzeitigen Therapiebeginn
und verbesserte Supportivbehandlung, in der Entwicklung neuer,
nicht kreuzresistenter Schemata zur Ausweich-Chemotherapie und ihre
Einbeziehung in die primare Induktions- oder Konsolidierungs-Chemo-
therapie, schlieBlich in der Erkennung von Risiko-Gruppen auch bei
akuter mye- loischer Leukamie und einer Risiko-adaptierten Therapie
oder Altemativ-Therapie.
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