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Tumor Aneuploidy (Paperback)
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Tumor Aneuploidy (Paperback)
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Chromosome abnormalities of cancer cells have been recognized for a
long time, and have generally proven to be a highly specific marker
ofmalignancy. The contri- butions collected in this book, "Tumor
Aneuploidy", cover several major aspects of present knowledge
conceming the occurrence and clinical significance of chromo- some
abnormalities as delineated by karyotype analyses or measurements
of the cellular DNA content. Certain non-random clonal chromosome
losses, deletions and translocations ap- pear to represent primary
genetic lesions of malignancies and reflect their clonal origin.
Secondary intraneoplastic genetic evolution is suggested by major
clonal ab- normalities of chromosome number and cellular DNA
content. Both types of ge- netic changes have been reaching great
relevance in cancer medicine, today. Although the Philadelphia
chromosome was first discovered in chronic myelo- cytic leukemia
(CML), by Nowell and Hungerford in 1960, new banding techniques
developed in the 1970's were needed to identity this abnormality as
a translocation between chromosomes 9 and 22 (t(9; 22)). Soon
thereafter, further non-random translocations were detected and
attributed to special diseases like t(8; 21) and t(15; 17) to acute
myeloid leukemias (AML) and t(9; 22), t(4; 11), t(8; 14) to acute
lymphoblastic leukemia (ALL).
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