Tumor Aneuploidy (Paperback)

Chromosome abnormalities of cancer cells have been recognized for a long time, and have generally proven to be a highly specific marker ofmalignancy. The contri- butions collected in this book, "Tumor Aneuploidy", cover several major aspects of present knowledge conceming the occurrence and clinical significance of chromo- some abnormalities as delineated by karyotype analyses or measurements of the cellular DNA content. Certain non-random clonal chromosome losses, deletions and translocations ap- pear to represent primary genetic lesions of malignancies and reflect their clonal origin. Secondary intraneoplastic genetic evolution is suggested by major clonal ab- normalities of chromosome number and cellular DNA content. Both types of ge- netic changes have been reaching great relevance in cancer medicine, today. Although the Philadelphia chromosome was first discovered in chronic myelo- cytic leukemia (CML), by Nowell and Hungerford in 1960, new banding techniques developed in the 1970's were needed to identity this abnormality as a translocation between chromosomes 9 and 22 (t(9; 22)). Soon thereafter, further non-random translocations were detected and attributed to special diseases like t(8; 21) and t(15; 17) to acute myeloid leukemias (AML) and t(9; 22), t(4; 11), t(8; 14) to acute lymphoblastic leukemia (ALL).

General

Imprint:	Springer-Verlag
Country of origin:	Germany
Release date:	November 1985
First published:	1985
Editors:	Thomas Buchner
Assisted by:	Michael Andreeff • B. Barlogie
Editors:	Clara D. Bloomfield • Wolfgang Hiddemann
Assisted by:	D.B. von Bassewitz
Editors:	Dieter K Hossfeld
Assisted by:	R. Becher
Editors:	Johannes Schumann
Assisted by:	Clara Bloomfield
Dimensions:	244 x 170 x 8mm (L x W x T)
Format:	Paperback
Pages:	141
ISBN-13:	978-3-540-15376-4
Categories:	Books > Medicine > Clinical & internal medicine > Haematology Books > Medicine > Clinical & internal medicine > Diseases & disorders > Oncology > General Promotions
LSN:	3-540-15376-4
Barcode:	9783540153764

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