![]() |
Welcome to Loot.co.za!
Sign in / Register |Wishlists & Gift Vouchers |Help | Advanced search
|
Your cart is empty |
||
Showing 1 - 12 of 12 matches in All Departments
When did 'good enough' become the same as 'perfect'? Why does society increasingly promote ideals that are completely unrealistic? And what does it mean for all of us that perfectionism is on the rise? In The Perfection Trap, you'll discover what's really driving the rise in perfectionism, its impact on how we learn, work, parent and relate to ourselves and each other. From the personal to the impact on the economy, grounded in over a decade of research and filled with real stories, this timely book reveals how our quest for perfection impacts our health and mental well-being and promises practical techniques and policy proposals to help us break free of the perfection trap.
Unlike some other reproductions of classic texts (1) We have not used OCR(Optical Character Recognition), as this leads to bad quality books with introduced typos. (2) In books where there are images such as portraits, maps, sketches etc We have endeavoured to keep the quality of these images, so they represent accurately the original artefact. Although occasionally there may be certain imperfections with these old texts, we feel they deserve to be made available for future generations to enjoy.
The two greatest medical fears of the aging population are cancer and Alzheimer's disease. Despite dramatic advances in understanding the molecular etiology of these disorders, therapeutic options for many patients with advanced disease have changed little and outcomes remain dismal. Paradoxically, recent findings suggest that some of the same molecules and biochemical processes underlying cancer may also participate in neurodegeneration. Therefore, it would be very useful to bring together experts from the fields of cancer research and neurodegeneration for discussions of the latest advances and ideas, with a particular emphasis on areas of overlap, to stimulate transdisciplinary interactions with the hope of accelerating progress. Cancer arises as a consequence of a breakdown in the genetic and epigenetic processes governing cell proliferation and cell death. Alterations in several classes of signaling molecules, both oncogenes and tumor suppressor genes, lead to uncontrolled cell growth. Over the past two decades, details of the intricate signaling pathways, from cell surface receptors through protein kinase cascades, transcription factors and modulators of chromatin, as well as the DNA damage response pathways linked to cell cycle control that guard the genome, have been uncovered. In some instances, key regulatory proteins have provided novel targets for development of small molecule inhibitors that are currently being tested in the clinic. The development of the nervous system relies on many of the signaling pathways and growth control processes that go awry in cancer. However, in mature neurons, the very same signaling proteins participate in transduction cascades linking short-term stimuli, elicited by synaptic stimulation, to long-term alterations in neuronal circuits through the regulation of gene expression and chromatin structure. These long-term adaptive modifications lead to changes in synaptic structure and function that
Homeostasis involves a delicate interplay between generative and degenerative processes to maintain a stable internal environment. In biological systems, equilibrium is established and controlled through a series of negative feedback mechanisms driven by a range of signal transduction processes. Failures in these complex communication pathways result in instability leading to disease. Cancer represents a state of imbalance caused by an excess of cell proliferation. In contrast, neurodegeneration is a consequence of excessive cell loss in the nervous system. Both of these disorders exhort profound tolls on humanity and they have been subject to a great deal of research designed to ameliorate this suffering. For the most part, the topics have been viewed as distinct and rarely do opportunities arise for transdisciplinary discussions among experts in both fields. However, cancer and neurodegeneration represent "yin-yang" counterpoints in the regulation of cell growth, and it is reasonable to hypothesize that key regulatory events mediated by oncogenes and tumor suppressor genes in cancer may also affect neurodegenerative processes
'Thomas Curran is the world's leading expert on perfectionism, and he's written the definitive book on why it's rising, how it wreaks havoc on our lives, and what we can do to stop it. If you've ever found yourself fearing failure, ruminating about mistakes, or just feeling that you aren't good enough, this is a must read' Adam Grant 'A fascinating and panoramic analysis of perfectionism in modern capitalist societies' Grace Blakeley Today, burnout and depression are at record levels, driven by a combination of intense workplace competition, the comparative world of social media, the quest for elite credentials, and helicopter parenting. Society continually broadcasts the need to want more, and that we have to be perfect to get it. Why is this a trap, and how can we escape it? Gathering a wide range of contemporary evidence, acclaimed professor at the London School of Economics Thomas Curran calls for both a mindset shift and broader, societal change. He explores the paradoxical effects of perfectionism on everything from performance to social and financial inequality, and shows what we can do as individuals to resist the modern-day pressure to be perfect - and how we can create a culture that celebrates the joys of imperfection. If you've ever felt overwhelmed by the soul-crushing need to compete for more or to be the best, The Perfection Trap is for you. Learn to prioritise what's important, meet the world where it is and strive for purpose instead of more by embracing the power of 'good enough' in your life.
This scarce antiquarian book is a selection from Kessinger Publishing's Legacy Reprint Series. Due to its age, it may contain imperfections such as marks, notations, marginalia and flawed pages. Because we believe this work is culturally important, we have made it available as part of our commitment to protecting, preserving, and promoting the world's literature. Kessinger Publishing is the place to find hundreds of thousands of rare and hard-to-find books with something of interest for everyone!
Book Description should read: May 1947 in St. John s, a woman is brutally murdered in her bath. In the same neighbourhood, in 1943, a young American soldier was also murdered, a crime that was never solved. Two murders, four years apart. One killer or two? Inspector Eric Stride of the Newfoundland Constabulary uncovers a complex web of evidence and circumstance, following a trail that goes back more than twenty years. Along the way, Stride finds that his own life is in danger.
|
You may like...
Amstrad Games Book - Cpc464 & Cpc664
Kevin Bergin, Andrew Lacey
Hardcover
R641
Discovery Miles 6 410
Low Cost Automation 1992, Volume 13…
P. Albertos, Peter Kopacek
Hardcover
R1,479
Discovery Miles 14 790
Exploring Neural Networks with C#
Ryszard Tadeusiewicz, Rituparna Chaki, …
Hardcover
R5,495
Discovery Miles 54 950
|