This book summarizes the latest findings about the role of cancer stem cells (CSCs) in cancer biology and how this knowledge could be used for novel anticancer therapies. It provides an overview of CSCs in selected malignancies with particular emphasis on hematopoietic neoplasias. It then reviews the role of CSCs in metastasis formation and initiation of cancer relapses. It also examines the dark site of cancer therapy such as conventional cancer therapies that may lead to the origin of recurrence CSCs. Finally, it supplies a brief overview of current concepts that may allow for a selective eradication of CSCs.

Stem Cell Biology in Health and Disease presents an up-to-date overview about the dual role of stem cells in health and disease. The Editors have drawn together an international team of experts providing chapters which, in this fully-illustrated volume, discuss: - the controversial debate on the great expectations concerning stem cell based regeneration therapies raised by the pluripotency of various stem cells. - the advantages and concerns about embryonic stem cells (ES cells), induced pluripotent stem cells (iPS cells) and adult stem cells, such as bone marrow-derived stem cells (BMDCs). - the type of stem cells, which has become of interest in the past decade, namely so-called cancer stem cells (CSCs). CSCs are now in the focus of cancer research since the eradication of tumour initiating cells would raise the changes of definitely cure cancer. Professor Dittmar and Professor Zanker have edited a must-read book for researchers and professionals working in the field of regenerative medicine and/or cancer.

Although cell fusion is an omnipresent process in life, to date considerably less is still known about the mechanisms and the molecules being involved in this biological phenomenon in higher organisms. In Cell Fusion in Health and Disease Vol 1 & Vol 2 leading experts will present up-to-date overviews about cell fusion in physiological and patho-physiological processes, which further covers the current knowledge about cell fusion-mediating molecules. Volume 1 deals with Cell Fusion in Health and will cover aspects of cell fusion in fertilization, placentation, in C. elegans, in skeletal muscle development and tissue repair, and the use of cell fusion for cellular reprogramming and cancer vaccine development. Volume 2 focuses on Cell Fusion in Disease with a particular emphasis on the role of cell fusion in cancer development and progression. Thus, Cell Fusion in Health and Disease Vol 1 & Vol 2 represents a state-of-the-art work for researchers, physicians or professionals being interested in the biological phenomenon of cell fusion and beyond.

Although cell fusion is an omnipresent process in life, to date considerably less is still known about the mechanisms and the molecules being involved in this biological phenomenon in higher organisms. In Cell Fusion in Health and Disease Vol 1 & Vol 2 leading experts will present up-to-date overviews about cell fusion in physiological and patho-physiological processes, which further covers the current knowledge about cell fusion-mediating molecules. Volume 1 deals with Cell Fusion in Health and will cover aspects of cell fusion in fertilization, placentation, in C. elegans, in skeletal muscle development and tissue repair, and the use of cell fusion for cellular reprogramming and cancer vaccine development. Volume 2 focuses on Cell Fusion in Disease with a particular emphasis on the role of cell fusion in cancer development and progression. Thus, Cell Fusion in Health and Disease Vol 1 & Vol 2 represents a state-of-the-art work for researchers, physicians or professionals being interested in the biological phenomenon of cell fusion and beyond.

Although cell fusion is an omnipresent process in life, to date considerably less is still known about the mechanisms and the molecules being involved in this biological phenomenon in higher organisms. In Cell Fusion in Health and Disease Vol 1 & Vol 2 leading experts will present up-to-date overviews about cell fusion in physiological and patho-physiological processes, which further covers the current knowledge about cell fusion-mediating molecules. Volume 1 deals with Cell Fusion in Health and will cover aspects of cell fusion in fertilization, placentation, in C. elegans, in skeletal muscle development and tissue repair, and the use of cell fusion for cellular reprogramming and cancer vaccine development. Volume 2 focuses on Cell Fusion in Disease with a particular emphasis on the role of cell fusion in cancer development and progression. Thus, Cell Fusion in Health and Disease Vol 1 & Vol 2 represents a state-of-the-art work for researchers, physicians or professionals being interested in the biological phenomenon of cell fusion and beyond.

Although cell fusion is an omnipresent process in life, to date considerably less is still known about the mechanisms and the molecules being involved in this biological phenomenon in higher organisms. In Cell Fusion in Health and Disease Vol 1 & Vol 2 leading experts will present up-to-date overviews about cell fusion in physiological and patho-physiological processes, which further covers the current knowledge about cell fusion-mediating molecules. Volume 1 deals with Cell Fusion in Health and will cover aspects of cell fusion in fertilization, placentation, in C. elegans, in skeletal muscle development and tissue repair, and the use of cell fusion for cellular reprogramming and cancer vaccine development. Volume 2 focuses on Cell Fusion in Disease with a particular emphasis on the role of cell fusion in cancer development and progression. Thus, Cell Fusion in Health and Disease Vol 1 & Vol 2 represents a state-of-the-art work for researchers, physicians or professionals being interested in the biological phenomenon of cell fusion and beyond.

Stem Cell Biology in Health and Disease presents an up-to-date overview about the dual role of stem cells in health and disease. The Editors have drawn together an international team of experts providing chapters which, in this fully-illustrated volume, discuss:

- the controversial debate on the great expectations concerning stem cell based regeneration therapies raised by the pluripotency of various stem cells.
- the advantages and concerns about embryonic stem cells (ES cells), induced pluripotent stem cells (iPS cells) and adult stem cells, such as bone marrow-derived stem cells (BMDCs).
- the type of stem cells, which has become of interest in the past decade, namely so-called cancer stem cells (CSCs). CSCs are now in the focus of cancer research since the eradication of tumour initiating cells would raise the changes of definitely cure cancer.

Professor Dittmar and Professor Zanker have edited a must-read book for researchers and professionals working in the field of regenerative medicine and/or cancer."

Thomas Dittmar untersucht das Einsatzpotenzial bankinterner Markte bei der Allokation von haftendem Eigenkapital und Ausfallrisikopositionen."

Today, cancer is the second most prevalent cause of death, after heart disease, in the industrialised world. Till now, and despite promising results in cancer research, the primary cause of death in cancer is still 1: the formation of metastases at distant organs sites, 2: the presence of cancer cells that are resistant to current cancer therapies (chemotherapy/radiation) and which cause cancer relapse. Within the past three years it became evident that also solid tumour tissues contain a kind of stem cells, so called cancer cells. These cancer stem cells have been described as chemo-radiation therapy resistant tumour initiating cells. The purpose of this book is to summarise the latest findings about the role of stem cells in cancer.

Diplomarbeit aus dem Jahr 1997 im Fachbereich BWL - Investition und Finanzierung, Note: 1, Universitat Augsburg (Wirtschafts und Sozialwissenschaften, Betriebswirtschaft), Veranstaltung: Lehrstuhl fur mathematische Methoden der Wirtschaftswissenschaften, Sprache: Deutsch, Abstract: Inhaltsangabe: Inhaltsverzeichnis: Inhaltsverzeichnis: 1.Einleitung 1.1Aktuelle Entwicklung der Insolvenzen 1.2Motivation und Ziel der Arbeit 1.3Gang der Darstellung 2.Grundlagen der Bonitatsprufung 2.1Gegenstand und Ziel der Bonitatsprufung 2.2Jahresabschlussanalyse: Verfahrensuberblick 2.3Verfahren der Kennzahlenanalyse 2.3.1Grundlagen 2.3.2Traditionelle Kennzahlenanalyse 2.3.3EDV-gestutzte Kennzahlenanalyse 3.Empirisch-induktive Verfahren 3.1Regressionsanalyse 3.2Diskriminanzanalyse: Grundlagen und Vorbereitungen 3.2.1Begriffsabgrenzung 3.2.2Zweiteilung des Datenmaterials 3.2.3Auswahl der Kennzahlen 3.2.4Festlegung der Zielsetzung 3.3Univariate Diskriminanzanalyse 3.4Multivariate Diskriminanzanalyse 3.4.1Prufung auf Normalverteilung 3.4.2Prufung auf Trennfahigkeit 3.4.3Das Problem der Multikollinearitat 3.4.4Gleichheit der Varianz-Kovarianz-Matrizen 3.4.5Ermittlung der Diskriminanzfunktion 3.4.6Vergleich der Methoden der MDA 3.5Mustererkennung 4.Kunstliche Neuronale Netze 4.1Grundlagen und Begriffsabgrenzung 4.1.1Das biologische Vorbild 4.1.2Das Neuron 4.1.3Die Netz-Topologie 4.1.4Die Lernregeln 4.2Exemplarische Beschreibung einiger Netztypen 4.2.1Das Perzeptron 4.2.1.1Grundlagen 4.2.1.2Das Trainingsverfahren fur das Perzeptron 4.2.1.3Beispiel 1: Das Perzeptron 4.2.2Das Multi-Layer-Perceptron 4.2.2.1Grundlagen 4.2.2.2Beispiel 2: Das XOR-Problem mit dem MLP 4.2.2.3Der Backpropagation-Algorithmus 4.2.2.4Beispiel 3: Der Backpropagation-Algorithmus 4.2.3Counterpropagation 4.2.4Learning Vector Quantization 4.3Probleme beim Training von KNN 4.3.1Overlearning 4.3.2Probleme im Zusammenhang mit dem Gradientenabstiegsverfahren 5.Bonitatsprufung mit Neuronalen Netzen 5.1Grundsatzliche Voruberlegu