As two relatively new fields of study, proteomics and nanotechnology have developed in parallel with each other to allow an increased precision in the identification of post-translational protein modifications as well as to provide a more automated isolation and detection of rare proteins in both serum and tissues. The Nanoproteomics: Methods and Protocols volume organizes and collects technical advances from leaders in the field to make laboratory protocols more readily available and understandable to those who are attempting to incorporate nanotechnologic techniques into their proteomic research. Conveniently divided into five sections, this detailed volume covers preliminary sample preparation, nanoscale fluidic devices and methods, nanostructured surfaces and nanomaterials, and nanoproteomic techniques to detect and understand protein and proteomic alterations specific to human pathology. Written in the highly successful series entitled Methods in Molecular Biology (TM), these chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step laboratory protocols that are readily reproducible, and tips on troubleshooting and avoiding known pitfalls. Convenient and authoritative, Nanoproteomics: Methods and Protocols offers key procedures that are culled from the laboratories of leaders in the field of nanoproteomics with the aim of helping researchers in their standardization and proliferation of protocols that will lead to a more wide scale adoption and smoother progress in this vital field.

Ludwig Binswanger (1881-1966) came from a distinguished Swiss psychiatrist dynasty which had run the internationally-renowned sanatorium Bellevue in Kreuz-lingen for generations. In 1907 he spent a year at the Zurich Burgh lzli under Bleuler and Jung, and indeed it was Jung who took Binswanger with him to Vienna that year for his first visit to Freud. The correspondence between the two men blossomed, and they became both friends and admirers of one another's work. Freud wrote to Binswanger on 26 December 1911: "I am quite sure you will live to see the recognition of psychoanalysis and that you will then be glad to have been among the rebels in your youth". Prophetic words, amply justified by the course of history.

At a time when traditional funding is diminishing and costs increasing, the need to look to new external sources of money is now central to survival for many organizations. New avenues of funding often demand a new outlook, and old ways of thinking can prove to be barriers to success. This book looks not only at methods for raising funds, providing practical steps in preparing for new funding initiatives, but also at the attitudes and mind-sets that form part of the whole picture. The volume is concise and accessible, with plans of action, bullet lists and diagrams for ease of consultation.

As two relatively new fields of study, proteomics and nanotechnology have developed in parallel with each other to allow an increased precision in the identification of post-translational protein modifications as well as to provide a more automated isolation and detection of rare proteins in both serum and tissues. The Nanoproteomics: Methods and Protocols volume organizes and collects technical advances from leaders in the field to make laboratory protocols more readily available and understandable to those who are attempting to incorporate nanotechnologic techniques into their proteomic research. Conveniently divided into five sections, this detailed volume covers preliminary sample preparation, nanoscale fluidic devices and methods, nanostructured surfaces and nanomaterials, and nanoproteomic techniques to detect and understand protein and proteomic alterations specific to human pathology. Written in the highly successful series entitled Methods in Molecular Biology (TM), these chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step laboratory protocols that are readily reproducible, and tips on troubleshooting and avoiding known pitfalls. Convenient and authoritative, Nanoproteomics: Methods and Protocols offers key procedures that are culled from the laboratories of leaders in the field of nanoproteomics with the aim of helping researchers in their standardization and proliferation of protocols that will lead to a more wide scale adoption and smoother progress in this vital field.

The glittering story of April Ashley, model and trans pioneer, and the divorce case which gripped 1960s Britain and defined transgender rights for a generation. As Britain emerged from post-war austerity in the 1960s, no one embodied its newfound spirit of hedonism and glamour like April Ashley. A fashion model and socialite who rose from poverty in Liverpool to the heights of London society via Le Carrousel nightclub in Paris, she was also one of the first Britons to undergo gender-affirming surgery. Ashley was appointed MBE for services to transgender equality in 2012, but her journey towards acceptance was hard-won and bitterly contested. In 1961, a friend sold her story to a tabloid and she was told that she would never work in the UK again. Her brief marriage to Arthur Corbett, the son of a baron, set off a high-profile divorce battle, resulting in a landmark 1970 decision denying transgender women legal status as women — and denying Ashley her husband’s inheritance. Drawing on a wide variety of sources, award-winning biographers Jacqueline Kent and Tom Roberts tell the full story of April Ashley’s extraordinary life at the vanguard of the sexual revolution and the movement for trans equality.

Rupert Murdoch's extraordinary career has no parallel. His control of Fox news, which so successfully supports the Trump presidency, is a key force in American politics. In the UK, his control of The Sun and The Times leaves politicians scrambling to get him onside. But what do we know about the man himself? This book looks closely at the Murdochs, focusing on Rupert's father Keith, who built the family's media power and cultivated the anti-establishment instincts that his son Rupert is known for. Roberts traces the life of the Murdochs, how Rupert Murdoch's view of the world was formed, and assesses it's impact on the media that influences our politics today.

Also Illustrated By Henry J. Recknell, Charles Nuttall, Harry J. Weston, Theo Brooke Hansen, And Others.

Also Illustrated By Henry J. Recknell, Charles Nuttall, Harry J. Weston, Theo Brooke Hansen, And Others.