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The development of effective methods for the prediction of
ontological annotations is an important goal in computational
biology, yet evaluating their performance is difficult due to
problems caused by the structure of biomedical ontologies and
incomplete annotations of genes. This work proposes an
information-theoretic framework to evaluate the performance of
computational protein function prediction. A Bayesian network is
used, structured according to the underlying ontology, to model the
prior probability of a protein's function. The concepts of
misinformation and remaining uncertainty are then defined, that can
be seen as analogs of precision and recall. Finally, semantic
distance is proposed as a single statistic for ranking
classification models. The approach is evaluated by analyzing three
protein function predictors of gene ontology terms. The work
addresses several weaknesses of current metrics, and provides
valuable insights into the performance of protein function
prediction tools.
This book is a children's poetry book on bullying.
All 21 episodes from the third series of the drama centred around a
platoon of US soldiers on a tour of Vietnam. The platoon, under the
command of 2nd Lieutenant Myron Goldman (Stephen Caffrey) and Staff
Sergeant Zeke Anderson (Terence Knox), face a variety of challenges
in the Vietnamese jungle: homesickness, internal quarrels and, of
course, their enemy, the Vietcong. The episodes are: 'The Luck',
'Doc Hock', 'The Ties That Bind', 'Lonely at the Top', 'A Bodyguard
of Lies', 'A Necessary End', 'Cloud Nine', 'Thanks for the
Memories', 'I Am What I Am', 'World in Changes', 'Green Christmas',
'Odd Man Out', 'And Make Death Proud to Take Us', 'Dead Man Tales',
'Road to Long Binh', 'Acceptable Losses', 'Vietnam Rag', 'War Is a
Contact Sport', 'Three Cheers for the Orange, White and Blue', 'The
Raid' and 'Payback'.
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