The development of effective methods for the prediction of ontological annotations is an important goal in computational biology, yet evaluating their performance is difficult due to problems caused by the structure of biomedical ontologies and incomplete annotations of genes. This work proposes an information-theoretic framework to evaluate the performance of computational protein function prediction. A Bayesian network is used, structured according to the underlying ontology, to model the prior probability of a protein's function. The concepts of misinformation and remaining uncertainty are then defined, that can be seen as analogs of precision and recall. Finally, semantic distance is proposed as a single statistic for ranking classification models. The approach is evaluated by analyzing three protein function predictors of gene ontology terms. The work addresses several weaknesses of current metrics, and provides valuable insights into the performance of protein function prediction tools.

This book is a children's poetry book on bullying.

All 21 episodes from the third series of the drama centred around a platoon of US soldiers on a tour of Vietnam. The platoon, under the command of 2nd Lieutenant Myron Goldman (Stephen Caffrey) and Staff Sergeant Zeke Anderson (Terence Knox), face a variety of challenges in the Vietnamese jungle: homesickness, internal quarrels and, of course, their enemy, the Vietcong. The episodes are: 'The Luck', 'Doc Hock', 'The Ties That Bind', 'Lonely at the Top', 'A Bodyguard of Lies', 'A Necessary End', 'Cloud Nine', 'Thanks for the Memories', 'I Am What I Am', 'World in Changes', 'Green Christmas', 'Odd Man Out', 'And Make Death Proud to Take Us', 'Dead Man Tales', 'Road to Long Binh', 'Acceptable Losses', 'Vietnam Rag', 'War Is a Contact Sport', 'Three Cheers for the Orange, White and Blue', 'The Raid' and 'Payback'.