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This collection discusses various micro/nanodevice design and
fabrication for single-biomolecules detection. It will be an ideal
reference text for graduate students and professionals in diverse
subject areas including materials science, biomedical engineering,
chemical engineering, mechanical engineering, and nanoscience. This
book- Discusses techniques of single-biomolecule detection, their
advantages, limitations, and applications. Covers comprehensively
several electrochemical detection techniques. Provides
single-molecule separation, sensing, imaging, sequencing, and
analysis in detail. Examines different types of cantilever-based
biomolecule sensing, and its limitations. Single Biomolecule
Detection and Analysis covers single-biomolecule detection and
characterization using micro/nanotechnologies and micro/nanofluidic
devices, electrical and magnetic detection technologies, microscopy
and spectroscopy techniques, single biomolecule optical, and
nanopore devices. The text covers key important biosensors-based
detection, stochastic optical reconstruction microscopy-based
detection, electrochemical detection, metabolic engineering of
animal cells, single-molecule intracellular delivery and tracking,
terahertz spectroscopy-based detection, total internal reflection
fluorescence (TIFR) detection, and Fluorescence Correlation
Spectroscopy (FCS) detection. The text will be useful for graduate
students and professionals in diverse subject areas including
materials science, biomedical engineering, chemical engineering,
mechanical engineering, and nanoscience. Discussing chemical
process, physical process, separation, sensing, imaging,
sequencing, and analysis of single-molecule detection, this text
will be useful for graduate students and professionals in diverse
subject areas including materials science, biomedical engineering,
chemical engineering, mechanical engineering, and nanoscience. It
covers microscopy and spectroscopy techniques for
single-biomolecule detection, analysis, and their biomedical
engineering applications.
This book highlights the evolution of, and novel challenges
currently facing, nanomaterials science, nanoengineering, and
nanotechnology, and their applications and development in the
biological and biomedical fields. It details different nanoscale
and nanostructured materials syntheses, processing,
characterization, and applications, and considers improvements that
can be made in nanostructured materials with their different
biomedical applications. The book also briefly covers the state of
the art of different nanomaterials design, synthesis, fabrication
and their potential biomedical applications. It will be
particularly useful for reading and research purposes, especially
for science and engineering students, academics, and industrial
researchers.
This book highlights the evolution of, and novel challenges
currently facing, nanomaterials science, nanoengineering, and
nanotechnology, and their applications and development in the
biological and biomedical fields. It details different nanoscale
and nanostructured materials syntheses, processing,
characterization, and applications, and considers improvements that
can be made in nanostructured materials with their different
biomedical applications. The book also briefly covers the state of
the art of different nanomaterials design, synthesis, fabrication
and their potential biomedical applications. It will be
particularly useful for reading and research purposes, especially
for science and engineering students, academics, and industrial
researchers.
This book provides an overview of single-cell isolation,
separation, injection, lysis and dynamics analysis as well as a
study of their heterogeneity using different miniaturized devices.
As an important part of single-cell analysis, different techniques
including electroporation, microinjection, optical trapping,
optoporation, rapid electrokinetic patterning and optoelectronic
tweezers are described in detail. It presents different fluidic
systems (e.g. continuous micro/nano-fluidic devices, microfluidic
cytometry) and their integration with sensor technology, optical
and hydrodynamic stretchers etc., and demonstrates the applications
of single-cell analysis in systems biology, proteomics, genomics,
epigenomics, cancer transcriptomics, metabolomics, biomedicine and
drug delivery systems. It also discusses the future challenges for
single-cell analysis, including the advantages and limitations.
This book is enjoyable reading material while at the same time
providing essential information to scientists in academia and
professionals in industry working on different aspects of
single-cell analysis. Dr. Fan-Gang Tseng is a Distinguished
Professor of Engineering and System Science at the National Tsing
Hua University, Taiwan. Dr. Tuhin Subhra Santra is a Research
Associate at the California Nano Systems Institute, University of
California at Los Angeles, USA.
This book provides an overview of single-cell isolation,
separation, injection, lysis and dynamics analysis as well as a
study of their heterogeneity using different miniaturized devices.
As an important part of single-cell analysis, different techniques
including electroporation, microinjection, optical trapping,
optoporation, rapid electrokinetic patterning and optoelectronic
tweezers are described in detail. It presents different fluidic
systems (e.g. continuous micro/nano-fluidic devices, microfluidic
cytometry) and their integration with sensor technology, optical
and hydrodynamic stretchers etc., and demonstrates the applications
of single-cell analysis in systems biology, proteomics, genomics,
epigenomics, cancer transcriptomics, metabolomics, biomedicine and
drug delivery systems. It also discusses the future challenges for
single-cell analysis, including the advantages and limitations.
This book is enjoyable reading material while at the same time
providing essential information to scientists in academia and
professionals in industry working on different aspects of
single-cell analysis. Dr. Fan-Gang Tseng is a Distinguished
Professor of Engineering and System Science at the National Tsing
Hua University, Taiwan. Dr. Tuhin Subhra Santra is a Research
Associate at the California Nano Systems Institute, University of
California at Los Angeles, USA.
This book provides a brief overview of single-cell analysis using
recent advanced technologies. The different sections cover
different aspect of single cell analysis and applications with
their advantages, limitations, and future challenges. The book has
covered how different physical energies such as optical,
electrical, and mechanical energy have been applied for single cell
therapy and analysis. The recent advanced micro/nanofluidic devices
have been employed for single-cell counting, manipulation,
cultivation, separation, isolation, lysis, printing and patterning
and host-viral interaction at single-cell level. Various chemical
approaches for single-cell analysis have been discussed, such as
liposome mediated materials transfer at single-cell and their
analysis, discovery of antibody via single-cell, high-throughput
screening of antigen-specific antibody-secreting cells, and
biomolecular secretion analysis of individual cells. Moreover,
different single-cell omics such as genomics, proteomics and
transcriptomics have been discussed using microfluidic technologies
as well as conventional approaches. The role of single cell
analysis in system biology and biocatalysis have been discussed in
detail. The book describes single-cell phenotyping of heterogeneous
tissue, stimulation, and instant reaction quenching technology for
biochemical kinetic analysis, large scale single-cell assay for the
identification of biocatalysts and analytical techniques for
single-cell studies in microbiology. The role of single-cell
analysis in cancer, such as single-cell adhesion and cancer
progression, single-cell technologies for cancer therapy,
analytical technology for single cancer cell analysis, and
biophysical markers for cancer cell analysis have been discussed.
The flow cytometry based high throughput single-cell analysis have
been well emphasized. Finally this book has covered single-cell
electrophysiology, single-cell sensing and size measurement using
mechanical and microwave resonators, molecular force spectroscopy
for cell adhesion measurement, micro-tweezers and force microscopy
techniques for single-cell mechanobiological analysis, mass
spectrometry and acoustic tweezers for single-cell manipulation and
analysis. This book is intended for academic and industrial
researchers, undergraduate and graduate students in the fields of
biomedical engineering, bio-micro/nanoengineering, and
bio-micro/nano fabrication for single-cell analysis. It can be used
for courses on bio-MEMS/bio-NEMS, biomicrofluidics,
bio-micro/nanofabrications, micro/nanofluidics, biophysics, single
cell analysis, bionanotechnology, drug delivery systems and
biomedical microdevices. Collective contributions from respected
experts, have brought diverse aspects of single-cell technologies
in a single hand book. This will benefit researchers and
practitioners in the biotechnology industry for different diseases
analysis, therapeutics, diagnostics, drug discovery, drug screening
etc. In addition to hard copies, the book will be available online
and will often be updated by the authors.
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