This book includes selected papers from the 2nd International Conference on Machine Learning and Information Processing (ICMLIP 2020), held at Vardhaman College of Engineering, Jawaharlal Nehru Technological University (JNTU), Hyderabad, India, from November 28 to 29, 2020. It presents the latest developments and technical solutions in the areas of advanced computing and data sciences, covering machine learning, artificial intelligence, human-computer interaction, IoT, deep learning, image processing and pattern recognition, and signal and speech processing.