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This book highlights progress and trends in the rapidly evolving
field of complement-related drug discovery and spotlights examples
of clinical applications. As an integral part of innate immunity
and critical mediator in homeostatic and inflammatory processes,
the human complement system has been identified as contributor to a
large number of disorders including ocular, cardiovascular,
metabolic, autoimmune, and inflammatory diseases as well as in
ischemia/reperfusion injury, cancer and sepsis. In addition,
complement is often involved in adverse immune reactions to
biomaterials, cell and organ transplants or drug delivery systems.
Although the complement cascade with its close to 50 extracellular
protein targets has long been recognized as an attractive system
for therapeutic modulation, the past few years have seen a
particularly strong boost in interest. Fueled by novel research
insight and the marketing of the first complement-targeted drugs, a
plethora of highly creative treatment approaches and potent drug
candidates have recently emerged and are currently evaluated in
disease models and clinical trials. The chapters in this book cover
a wide range of topics related to the development of complement
therapeutics, ranging from the molecular and functional description
of complement targets to the presentation of novel inhibitors,
improved treatment strategies as well as examples of disease models
and clinical applications. The broad and up-to-date overview on a
highly versatile and dynamic field renders this book an
indispensable source of information for researchers and clinicians
dealing with therapeutic and disease-related aspects of the human
complement system.
This book highlights progress and trends in the rapidly evolving
field of complement-related drug discovery and spotlights examples
of clinical applications. As an integral part of innate immunity
and critical mediator in homeostatic and inflammatory processes,
the human complement system has been identified as contributor to a
large number of disorders including ocular, cardiovascular,
metabolic, autoimmune, and inflammatory diseases as well as in
ischemia/reperfusion injury, cancer and sepsis. In addition,
complement is often involved in adverse immune reactions to
biomaterials, cell and organ transplants or drug delivery systems.
Although the complement cascade with its close to 50 extracellular
protein targets has long been recognized as an attractive system
for therapeutic modulation, the past few years have seen a
particularly strong boost in interest. Fueled by novel research
insight and the marketing of the first complement-targeted drugs, a
plethora of highly creative treatment approaches and potent drug
candidates have recently emerged and are currently evaluated in
disease models and clinical trials. The chapters in this book cover
a wide range of topics related to the development of complement
therapeutics, ranging from the molecular and functional description
of complement targets to the presentation of novel inhibitors,
improved treatment strategies as well as examples of disease models
and clinical applications. The broad and up-to-date overview on a
highly versatile and dynamic field renders this book an
indispensable source of information for researchers and clinicians
dealing with therapeutic and disease-related aspects of the human
complement system.
A team of expert investigators and clinical researchers
comprehensively review complement's basic biology, its role in
disease, methods to measure its activity, and strategies for its
inhibition in patients. Each chapter focuses on a specific area of
basic and applied complement biology, spelling out the activation
pathways and complement receptors. Informative animal models are
discussed in detail, including the relative values of each model
and the important interspecies differences that can distort the
interpretation of preclinical studies. The emphasis throughout is
on the pros and cons of the therapeutic use of recombinant
complement inhibitors in specific diseases. Cutting-edge and
innovative, Therapeutic Interventions in the Complement System
highlights for today's researcher and biotechnologist effective
strategies of drug discovery and development that are producing
valuable new complement inhibitors for the treatment of a wide
variety of clinically important diseases.
A team of expert investigators and clinical researchers
comprehensively review complement's basic biology, its role in
disease, methods to measure its activity, and strategies for its
inhibition in patients. Each chapter focuses on a specific area of
basic and applied complement biology, spelling out the activation
pathways and complement receptors. Informative animal models are
discussed in detail, including the relative values of each model
and the important interspecies differences that can distort the
interpretation of preclinical studies. The emphasis throughout is
on the pros and cons of the therapeutic use of recombinant
complement inhibitors in specific diseases. Cutting-edge and
innovative, Therapeutic Interventions in the Complement System
highlights for today's researcher and biotechnologist effective
strategies of drug discovery and development that are producing
valuable new complement inhibitors for the treatment of a wide
variety of clinically important diseases.
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