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Books > Science & Mathematics > Biology, life sciences > Microbiology (non-medical)
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Complement Therapeutics (Paperback, Softcover reprint of the original 1st ed. 2013)
Loot Price: R5,757
Discovery Miles 57 570
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Complement Therapeutics (Paperback, Softcover reprint of the original 1st ed. 2013)
Series: Advances in Experimental Medicine and Biology, 735
Expected to ship within 10 - 15 working days
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This book highlights progress and trends in the rapidly evolving
field of complement-related drug discovery and spotlights examples
of clinical applications. As an integral part of innate immunity
and critical mediator in homeostatic and inflammatory processes,
the human complement system has been identified as contributor to a
large number of disorders including ocular, cardiovascular,
metabolic, autoimmune, and inflammatory diseases as well as in
ischemia/reperfusion injury, cancer and sepsis. In addition,
complement is often involved in adverse immune reactions to
biomaterials, cell and organ transplants or drug delivery systems.
Although the complement cascade with its close to 50 extracellular
protein targets has long been recognized as an attractive system
for therapeutic modulation, the past few years have seen a
particularly strong boost in interest. Fueled by novel research
insight and the marketing of the first complement-targeted drugs, a
plethora of highly creative treatment approaches and potent drug
candidates have recently emerged and are currently evaluated in
disease models and clinical trials. The chapters in this book cover
a wide range of topics related to the development of complement
therapeutics, ranging from the molecular and functional description
of complement targets to the presentation of novel inhibitors,
improved treatment strategies as well as examples of disease models
and clinical applications. The broad and up-to-date overview on a
highly versatile and dynamic field renders this book an
indispensable source of information for researchers and clinicians
dealing with therapeutic and disease-related aspects of the human
complement system.
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