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A step-by-step guide to commonly used procedures, Methods in Cellular Immunology addresses both human and murine models, in addition to such topics as PCR and apoptosis. The basic format of the original version has been maintained, and the goal remains the same: to make it a useful and easy-to-use tool for investigators employing cellular immunological techniques in their research, regardless of whether or not immunology is their main area of expertise. It provides information about manufacturers and commercial sources of chemicals and reagents and a comprehensive list of references, allowing readers to refer back to the original information and/or techniques.
At present, we do not fully understand at what stage of the
evolution of living matter the first traces of defense reactions
occurred. We even do not fully understand how and why immune
systems reached their contem porary state in advanced vertebrates
and man. It may be expected that in the near future these questions
will be answered by comparative and develop mental biology.
Together with an extraordinary explosion of our knowledge about
immunity of mammals including man, an increase in the interests
concerning origin and development of immune mechanisms at lower
stages of the phylogeny can be observed. The search for simple
types of immune mechanisms in less complex but still evolutionary
successful animals is promising and may contribute to better
understanding of highly complex immune adaptive responses in
mammals. It is important to note that comparative and evolutionary
immunology differs greatly from other branches of biomedical
science. Apart from immunology and molecular biology, a specialist
in this discipline has to be familiar with every detail of
taxonomy, comparative anatomy, physiology, embryology, and even
with the phyletic relationships of animals. Probably no monography
could deal with the entire animal kingdom, because, in many cases,
the insights into questions about immune mecha nisms of many animal
groupings or phyla, and their possible evolutionary implications,
are unknown or just now beginning to take shape. For the moment,
our knowledge on such matters relies upon reconstructions of ideas
that we have deduced from studies on members of relative taxa."
It is well established that among the many known and tested
immunomodulators, polysaccharides isolated from various natural
sources occupy a prominent position. beta-Glucans belong to a group
of biologically active natural compounds called biological response
modifiers. These substances represent highly conserved structural
components of cell walls in yeast, fungi, grain and seaweed. Its
role as an immunomodulator has been well documented for over 50
years. Initial interest in the immunomodulatory properties of
polysaccharides was raised after experiments revealed that a crude
yeast cell preparation stimulated macrophages via activation of
complement. Glucan represents a type of immunostimulant that is
active over the full spectrum of biological species, which allowed
glucan to be used as a potent immunostimulator in commercially
important species such as shrimps, fish or pigs. In the last
decade, a renewed interest in human application has brought about
some important studies on orally-administered glucan resulting in
18 currently running clinical trials.Fortunately, in the last
years, research in reputable laboratories has reached a phase when
the basic mechanisms of beta-glucan effects are known and the
relationship between structure and activity were clearly
established. It seems now that beta-glucans will finally take a
position which was ascribed to them more than fifty years ago.
This book represents an evolutionary approach to defense
mechanisms of all living organisms. The results achieved in
developmental and comparative immunology are among the most
interesting data in immunology. These results have great impact on
our understanding fundamental problems of the pathology of the
human immune system. At the same time, the field of evolutionary
immunology provides not only inspiration for further investigation
in biomedicine, but also a number of results applicable in clinical
and commercial practice.
This book evaluates the advantages and limitations of studying
the development of defense reactions. In addition to reviewing the
major and crucial achievements of the past, the book offers a
comprehensive state-of-the-art treatise focused primarily on the
latest experiments described in the last few years.
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Immune System Accessory Cells (Hardcover)
Lubor Fornusek; Contributions by Miroslav Holub; Vaclav Vetvicka; Contributions by Lee D. Leserman, Philippe Naquet, …
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R9,845
Discovery Miles 98 450
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Ships in 12 - 17 working days
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Immune System Accessory Cells provides a comprehensive survey of
all types of antigen-presenting and accessory cells. Macrophages
are emphasized through descriptions of different types of
endocytosis, other major properties, and all basic and new
information concerning macrophages as antigen-presenting cells.
Other topics covered include the impact of the immunodeficient
state on accessory functions, the evolutionary emergence of
accessory functions, and the role of various cell types in defense
reactions in major assemblages of Metazoa. The book also presents a
chapter describing the phylogenetic aspects of accessory functions,
which traces the first accessory cells during the evolution of
living matter. Immune System Accessory Cells is an excellent
reference for immunologists, cell biologists, and others interested
in developing an understanding of the roles of accessory cells in
all facets of immune reactions.
Immunologists as well investigators in other disciplines may often
use protocols involving the isolation, cultures and
characterization of different types of leukocytes. Advanced Methods
in Cellular Immunology is a collection of techniques in an
easy-to-use format.
Each chapter provides readers with related program information, a
step-by-step description of the methodology, alternative
techniques, pertinent references, and information about commercial
sources for materials and regents. In addition to leukocytes, the
authors guide readers through the processes of cell culture as well
as inflammation and autoimmunity in a variety of animal
models.
Covering topics such as PCR and Apoptosis, this book will serve a
guide to commonly used procedures in cellular immunology while
utilizing both human and murine models.
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