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Since its discovery in 1957, Coenzyme Q has piqued the interest of scientists from a wide range of disciplines because of its bioenergetics, vitamin-like behavior, and interactions with antioxidant vitamins E and C. Coenzyme Q: Molecular Mechanisms in Health and Disease is a comprehensive treatise on this often-studied coenzyme. International experts cover the research that led to its emergence as an exciting, new dietary supplement.
The present volume summarizes the latest developments in various areas of CoQ research. New concepts on extramitochondrial functions of CoQ are discussed in two chapters, while recent discoveries in biosynthetic pathways for CoQ based on molecular genetic approaches are presented in another chapter.
Further chapters explore the role of CoQ as an antioxidant, revealing the need for additional research in this exciting area.
This book will be of extreme interest to biochemists, biophysicists, molecular and cell biologists, as well as nutritionists and biomedical health workers.
This book will explain the colossal potential of life to cope with
different living environments is possible owing to the
exceptionally well developed mechanisms of adaptation to
environmental conditions. There is an innumerable variety of
concrete mechanisms which make it possible for living creatures to
adapt to different and changing environmental conditions.
Nevertheless, all this variety is the manifestation of the three
strategic line of the adaptation process: 1. Evolutional or
genotypic adaptation. 2. Phenotypic adaptation. 3. Rapid
adaptation.
The subject for a volume on the fat-soluble vitamins needs no
justification considering the importance of this group of nutrients
and the rate of expan sion of our knowledge of its role in cell
biology, genetics, and disease. The level of our understanding has
clearly moved from knowing what fat soluble vitamins do to how they
perform their functions. Hand in hand with a knowledge of their
molecular mechanisms of action is the recognition that vitamins are
used sparingly, and regeneration processes operate in certain cases
to recycle vitamins from their metabolites. We have divided the
volume into alphabetical sections beginning with vitamin A and the
carotenoids through vitamins D, E, F, and K, and ending with
coenzyme Q. The contributors are all acknowledged experts in their
particular fields and have made significant contributions to
published research results. All have worked assiduously to deliver
the product of their labors on a restricted time scale and to
provide the most up-to date information on their respective topics.
We are truly grateful for their indulgence."
The last few years have witnessed an explosion of both interest and
knowledge about apoptosis, the process by which a cell actively
commits suicide. The number of publications on the topic has
increased from nothing in the early 1980s to more than 10,000
papers annually today. It is now well recognized that apoptosis is
essential in many aspects of normal development and is required for
maintaining tissue homeostasis. The idea that life requires death
seems somewhat paradoxical, but cell suicide is essential for an
animal to survive. For example, without selective destruction of
"non-self" T cells, an animal would lack immunity. Similarly,
meaningful neural connections in the brain are whittled from a mass
of cells. Further, developmental cell remodeling during tissue
maturation involves programmed cell death as the major mechanism
for functional and structural safe transition of undifferentiated
cells to more specialized counterparts. Apoptosis research, with
roots in biochemistry, developmental and cell biology, genetics,
and immunology, embraces this long-ignored natural law. Failure to
properly regulate apoptosis can have catastrophic consequences.
Cancer and many diseases (AIDS, Alzheimer's disease, Parkinson's
disease, heart attack, stroke, etc. ) are thought to arise from
deregulation of apoptosis. As apoptosis emerges as a key biological
regulatory mechanism, it has become harder and harder to keep up
with new developments in this field.
The last few years have witnessed an explosion of both interest and
knowledge about apoptosis, the process by which a cell actively
commits suicide. The number of publications on the topic has
increased from nothing in the early 1980s to more than 10,000
papers annually today. It is now well recognized that apoptosis is
essential in many aspects of normal development and is required for
maintaining tissue homeostasis. The idea that life requires death
seems somewhat paradoxical, but cell suicide is essential for an
animal to survive. For example, without selective destruction of
"non-self" T cells, an animal would lack immunity. Similarly,
meaningful neural connections in the brain are whittled from a mass
of cells. Further, developmental cell remodeling during tissue
maturation involves programmed cell death as the major mechanism
for functional and structural safe transition of undifferentiated
cells to more specialized counterparts. Apoptosis research, with
roots in biochemistry, developmental and cell biology, genetics,
and immunology, embraces this long-ignored natural law. Failure to
properly regulate apoptosis can have catastrophic consequences.
Cancer and many diseases (AIDS, Alzheimer's disease, Parkinson's
disease, heart attack, stroke, etc. ) are thought to arise from
deregulation of apoptosis. As apoptosis emerges as a key biological
regulatory mechanism, it has become harder and harder to keep up
with new developments in this field.
The subject for a volume on the fat-soluble vitamins needs no
justification considering the importance of this group of nutrients
and the rate of expan sion of our knowledge of its role in cell
biology, genetics, and disease. The level of our understanding has
clearly moved from knowing what fat soluble vitamins do to how they
perform their functions. Hand in hand with a knowledge of their
molecular mechanisms of action is the recognition that vitamins are
used sparingly, and regeneration processes operate in certain cases
to recycle vitamins from their metabolites. We have divided the
volume into alphabetical sections beginning with vitamin A and the
carotenoids through vitamins D, E, F, and K, and ending with
coenzyme Q. The contributors are all acknowledged experts in their
particular fields and have made significant contributions to
published research results. All have worked assiduously to deliver
the product of their labors on a restricted time scale and to
provide the most up-to date information on their respective topics.
We are truly grateful for their indulgence."
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