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This book guides through the fascinating world of viruses and makes
readers enjoy science in an accessible way. Virologist and author
Professor Van Wilson imparts knowledge about what viruses are, how
they work, and how much they impact life on Earth. The book equips
the reader with the scientific basics behind virus function and
presents the historic milestones of virus research and discovery.
Well-known viruses such as HIV or Influenza are tackled alongside
novel pathogens like coronavirus SARS-CoV-2. Professor Wilson
explores where they come from and how they impact our society. Last
but not least the book provides exciting insights into how our
immune system reacts to different viruses and how vaccines
contribute to conquer pandemics. While scientifically informative,
this book makes the field of virology understandable to a lay
audience and encourages readers to further thinking. And more
importantly, it conveys the wonder, beauty, and mystery of these
ubiquitous, microscopic marvels. This book addresses anyone
interested in understanding the principles of virology, viral
diseases, or the impact of viruses on human societies.
This is the second edition of a very well received book that
details how the sumoylation system functions and how it modulates
numerous cellular activities. SUMO is a post-translational modifier
in the ubiquitin super-family that has gained recognition over the
last twenty years as an essential and prevalent regulatory
molecule. Individual chapters explore the biochemistry, molecular
biology, and cell biology of the sumoylation system and its
substrate proteins. The book is divided into three themed parts:
Molecular Functions (I), Cell Growth Regulation (II), and Diseases
(III). Parts I and II focus on the contribution of sumoylation to
cellular activities in both the nuclear and cytoplasmic
compartments. The nuclear activities covered include nucleic acid
metabolism (both RNA and DNA), chromosome structure and
replication, and nucleocytoplasmic transport. Cytoplasmic processes
presented include regulation of membrane ion channels, general
metabolism, and apoptotic signalling. Topics in Part III include
the role of sumoylation in developmental abnormalities
(craniofacial and cardiovascular), diabetes, neurodegenerative
diseases, cancer, and infections with viruses and bacteria. Each of
the corresponding chapter authors is an active researcher who has
made significant contributions to understanding sumoylation. This
second edition provides updates and revisions to most of the
original chapters plus adds six new chapters to address important
developing areas of sumoylation research. This volume is intended
for a scientific audience from undergraduates to independent
researchers. The content will serve as both a solid introduction
for the novice reader and an in depth treatment for the advanced
scholar.
This is the second edition of a very well received book that
details how the sumoylation system functions and how it modulates
numerous cellular activities. SUMO is a post-translational modifier
in the ubiquitin super-family that has gained recognition over the
last twenty years as an essential and prevalent regulatory
molecule. Individual chapters explore the biochemistry, molecular
biology, and cell biology of the sumoylation system and its
substrate proteins. The book is divided into three themed parts:
Molecular Functions (I), Cell Growth Regulation (II), and Diseases
(III). Parts I and II focus on the contribution of sumoylation to
cellular activities in both the nuclear and cytoplasmic
compartments. The nuclear activities covered include nucleic acid
metabolism (both RNA and DNA), chromosome structure and
replication, and nucleocytoplasmic transport. Cytoplasmic processes
presented include regulation of membrane ion channels, general
metabolism, and apoptotic signalling. Topics in Part III include
the role of sumoylation in developmental abnormalities
(craniofacial and cardiovascular), diabetes, neurodegenerative
diseases, cancer, and infections with viruses and bacteria. Each of
the corresponding chapter authors is an active researcher who has
made significant contributions to understanding sumoylation. This
second edition provides updates and revisions to most of the
original chapters plus adds six new chapters to address important
developing areas of sumoylation research. This volume is intended
for a scientific audience from undergraduates to independent
researchers. The content will serve as both a solid introduction
for the novice reader and an in depth treatment for the advanced
scholar.
The Horizon Bioscience series focuses on high-level microbiology
and molecular biology topics. Written by internationally renowned
and highly respected leaders in the field, titles in this series
comprise of review manuals, practical manuals, and reference texts
for research scientists, bioscience professionals and graduate
students. Sumoylation is a novel posttranslational modification
system, biochemically analogous to, but functionally distinct from,
ubiquitinylation. Sumoylation involves the covalent attachment of a
SUMO (small ubiquitin-related modifier) to substrate proteins. This
modification system has crucial roles in many different biological
processes, including protein localization and stability,
transcriptional activities, nucleocytoplamic signalling and
transport, and genome replication, as well as the regulation of
gene expression. The molecular and biochemical mechanisms involved
in sumoylation have been the subject of intense interest in recent
years. This volume, edited and written by leading international
experts, is the first book to be devoted to sumoylation. It
presents information on the history, evolution and mechanisms of
sumoylation, discusses SUMO proteases, ligases and conjugation
pathways, and reviews the impact on modification and
nucleocytoplasmic transport, PML nuclear bodies, and
transcriptional regulation. In addition, specialist chapters cover
the role of sumoylation in yeast, viruses and the tumor suppressor
P53. This comprehensive book is the definitive reference volume on
all aspects of sumoylation. It is an essential reference manual for
all researchers in this area.
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