Nanoparticles have gained much attention as a promising drug delivery system due to their unique properties. Rosiglitazone maleate, an antidiabetic agent, acts as a highly selective and potent agonist for PPAR receptors in target tissues for insulin action. In spite of its high efficiency, side effects limit the clinical use. To reduce the side effects of conventional dosage form, rosiglitazone loaded nanoparticles have been formulated. Nanoparticles were formulated by gelatin and chitosan via double desolvation and ionotropic gelation technique respectively, & subjected to photon correlation spectroscopy, transmission electron microscopy & encapsulation efficiency studies. These studies favorably revealed that the mean particle diameter of optimized formulation was 49 nm (gelatin) and 86 nm (chitosan) with spherical morphology. The optimized formulation demonstrated favorable in vitro prolonged release characteristics with zero order, diffusion and erosion mechanisms. Nanoparticles also showed excellent stability. Hence, the designed delivery system can be fine tuned on the depending clinical applications.

Well known and well regarded in the world of science fiction and fantasy writing, Vandana Singh brings her unique imagination to a wider audience in this collection of stories, newly reissued by Zubaan Books. In the title story, a woman tells her husband of her curious discovery: that she is inhabited by small alien creatures. In another, a young girl making her way to college through the streets of Delhi comes across a mysterious tetrahedron. Is it a spaceship? Or a secret weapon?
The first Indian female speculative fiction writer, Singh has said that her genre is a "chance to find ourselves part of a larger whole; to step out of the claustrophobia of the exclusively human and discover joy, terror, wonder, and meaning in the greater universe." A revolutionary voice in fantasy writing, Singh brings her passion for discovery to these stories, and the result is like nothing of this world.