Ubiquitous and fundamental in cell mechanics, multiscale problems can arise in the growth of tumors, embryogenesis, tissue engineering, and more. Cell Mechanics From Single Scale-Based Models to Multiscale Modeling brings together new insight and research on mechanical, mathematical, physical, and biological approaches for simulating the behavior of cells, specifically tumor cells.

In the first part of the text, the book discusses the powerful tool of microrheology for investigating cell mechanical properties, multiphysics and multiscale approaches for studying intracellular mechanisms in cell motility, and the role of subcellular effects involving certain genes for inducing cell motility in cancer. Focusing on models based on physical, mathematical, and computational approaches, the second section develops tools for describing the complex interplay of cell adhesion molecules and the dynamic evolution of the cell cytoskeleton. The third part explores cell interactions with the environment, particularly the role of external mechanical forces and their effects on cell behavior. The final part presents innovative models of multicellular systems for developmental biology, cancer, and embryogenesis.

This book collects novel methods to apply to cells and tissues through a multiscale approach. It presents numerous existing tools while stimulating the discovery of new approaches that can lead to more effective and accurate predictions of pathologies.

What are the challenges and action points for agricultural sustainability in Sub-Saharan Africa? This open access collection of papers offers technical analyses, policy recommendations and an overview of success stories to date. Each carefully selected paper provides valuable insights for improved policy making and defines relevant strategic priorities on Africa's sustainable transformation process, which is in line with the international development agenda. Although agriculture remains the main source of income for Africa's population, the sector is rain-fed subjecting it to the vagaries of weather and climate change. This volume demonstrates the rationale of developing a competitive, inclusive and sustainable agribusiness sector for Africa's food security and structural transformation. From the impact of Bioenergy crop adoption and Drought Index Insurance to Agro-Industrialization, this volume is important reading for individual researchers, academic associations and professional bodies interested in African agricultural development.

This book reviews the current trends and challenges of regional integration and trade in Africa. It provides valuable policy recommendations aimed at stimulating the debate among the government, private sector and development community on the ways to promote regional trade for Africa's economic development.

A century of technical progress, critical analyses, and clinical comparisons have shaped exercise testing in cardiology as we know it today: a simple, noninvasive physiological test that yields irreplaceable information on an individual s physical capacity and ischemic risk. Increasingly prescribed, exercise testing is one of the mostly commonly used medical examinations worldwide. It is both diagnostically and prognostically valuable, and is optimized when combined with myocardial perfusion imaging.. Its indications are broadened every day and there is a good chance that each and every one of us has had, or will one day have, an exercise test. This short and precise book follows a pragmatic and hands-on approach to help physicians who prescribe exercise testing to identify its indications, advantages, and limits. And in interpreting the findings they will find invaluable help in the section entitled: What should be done with exercise test results? As for those who perform exercise tests whether beginners or experts they will find in these pages precious details and facts that can be profitably employed in their everyday practice."

"With contributions by experts from official agencies in Africa, international financial institutions, the private sector, and academia, this book focuses on financial sector development in Sub-Saharan Africa and how institutions can play a more active role in economic development"--Provided by publisher.

The definitive reference on the most current economics of development and institutions The essential role that institutions play in understanding economic development has long been recognized across the social sciences, including in economics. Academic and policy interest in this subject has never been higher. The Handbook of Economic Development and Institutions is the first to bring together in one single volume the most cutting-edge work in this area by the best-known international economists. The volume's editors, themselves leading scholars in the discipline, provide a comprehensive introduction, and the stellar contributors offer up-to-date analysis into institutional change and its interactions with the dynamics of economic development. This book focuses on three critical issues: the definitions of institutions in order to argue for a causal link to development, the complex interplay between formal and informal institutions, and the evolution and coevolution of institutions and their interactions with the political economy of development. Topics examined include the relationship between institutions and growth, educational systems, the role of the media, and the intersection between traditional systems of patronage and political institutions. Each chapter-covering the frontier research in its area and pointing to new areas of research-is the product of extensive workshopping on the part of the contributors. The definitive reference work on this topic, The Handbook of Economic Development and Institutions will be essential for academics, researchers, and professionals working in the field.

Ubiquitous and fundamental in cell mechanics, multiscale problems can arise in the growth of tumors, embryogenesis, tissue engineering, and more. Cell Mechanics: From Single Scale-Based Models to Multiscale Modeling brings together new insight and research on mechanical, mathematical, physical, and biological approaches for simulating the behavior of cells, specifically tumor cells. In the first part of the text, the book discusses the powerful tool of microrheology for investigating cell mechanical properties, multiphysics and multiscale approaches for studying intracellular mechanisms in cell motility, and the role of subcellular effects involving certain genes for inducing cell motility in cancer. Focusing on models based on physical, mathematical, and computational approaches, the second section develops tools for describing the complex interplay of cell adhesion molecules and the dynamic evolution of the cell cytoskeleton. The third part explores cell interactions with the environment, particularly the role of external mechanical forces and their effects on cell behavior. The final part presents innovative models of multicellular systems for developmental biology, cancer, and embryogenesis. This book collects novel methods to apply to cells and tissues through a multiscale approach. It presents numerous existing tools while stimulating the discovery of new approaches that can lead to more effective and accurate predictions of pathologies.

What are the challenges and action points for agricultural sustainability in Sub-Saharan Africa? This open access collection of papers offers technical analyses, policy recommendations and an overview of success stories to date. Each carefully selected paper provides valuable insights for improved policy making and defines relevant strategic priorities on Africa's sustainable transformation process, which is in line with the international development agenda. Although agriculture remains the main source of income for Africa's population, the sector is rain-fed subjecting it to the vagaries of weather and climate change. This volume demonstrates the rationale of developing a competitive, inclusive and sustainable agribusiness sector for Africa's food security and structural transformation. From the impact of Bioenergy crop adoption and Drought Index Insurance to Agro-Industrialization, this volume is important reading for individual researchers, academic associations and professional bodies interested in African agricultural development.

In this ambitious exploration of how foreign trade policy is made in democratic regimes, Daniel Verdier shows that special interests, party ideologues, and state officials and diplomats act as agents of the voters. Constructing a general theory in which existing theories (rent-seeking, median voting, state autonomy) function as partial explanations, he shows that trade institutions are not fixed entities but products of political competition.

Domestic revenue mobilization has been a longstanding challenge for countries in the Middle East and Central Asia. Insufficient revenue has often constrained priority social and infrastructure spending, reducing countries' ability to reach the Sustainable Development Goals, improve growth prospects, and address climate related challenges. Moreover, revenue shortfalls have often been compensated by large and sustained debt accumulation, raising vulnerabilities in some countries, and limiting fiscal space to address future shocks. The COVID-19 pandemic and the war in Ukraine have compounded challenges to sustainable public finances, underscoring the need for revenue mobilization efforts. The recent global crises have also exacerbated existing societal inequalities and highlighted the importance of raising revenues in an efficient and equitable manner. This paper examines the scope for additional tax revenue mobilization and discusses policies to gradually raise tax revenue while supporting resilient growth and inclusion in the Middle East and Central Asia. The paper's main findings are that excluding hydrocarbon revenues, the region's average tax intake lags those of other regions; the region's fragile and conflict-affected states (FCS) face particular challenges in mobilizing tax revenue; In general, there is considerable scope to raise additional tax revenue; countries have made efforts to raise tax collection, but challenges remain; tax policy design, notably low tax rates and pervasive tax exemptions, is an important factor driving tax revenue shortfalls; weak tax compliance, reflecting both structural features and challenges in revenue administration, also plays a role; and personal income tax systems in the region vary in their progressivity—the extent to which the average tax rate increases with income—and in their ability to redistribute income. These findings provide insights for policy action to raise revenue while supporting resilient growth and inclusion. The paper's analysis points to these priorities for the region to improve both efficiency and equity of tax systems: improving tax policy design to broaden the tax base and increase progressivity and redistributive capacity; strengthening revenue administration to improve compliance; and implementing structural reforms to incentivize tax compliance, formalization, and economic diversification.

A masterpiece of ethnographic observation on seventeenth-century Spain.   While mysteries remain in her biography, Madame d’Aulnoy’s tremendous literary talent is finally being rediscovered. Marie-Catherine Le Jumel de Barneville, baronne d’Aulnoy (1652–1705) was the first Frenchwoman to write, publicize, and publish the account of her travels into Spain as an independent woman. Considered the authority on Spain for nearly two centuries until historiographers labeled them as disreputable, Travels into Spain can now be appreciated for its ironic gaze on realities concealed from male travelers and Madame d’Aulnoy’s unabashedly female and often playful voice. Her writing casts a unique light on gender relations, the condition of women, cultural biases, national rivalries, and religious superstitions at a critical time in early modern cultural and literary history. The first modern translation of Travels into Spain, this book situates Madame d’Aulnoy’s account in its historical context. Travels into Spain is a masterpiece of ethnographic observation, expressing a woman’s view on gender relations, marriage, religion, fashion, food, bullfights, and the Inquisition.     

ltats - avec une generalite minimale, souvent insuffisante pour les applications -et une idee de leur demonstration. Pour des resultats complets, ou des demonstrationsdetaillees, SGA 4 reste indispensable.Le "Rapport sur la formule des traces" contient une demonstration complete dela formule des traces pour l'endomorphisme de Frobenius. La demonstration est celledonnee par Grothendieck dans SGA 5, elaguee de tout detail inutile. Ce rapportdevrait permettre a utilisateur d'oublier SGA 5, qu'on pourra considerer comme uneserie de digression, certaines tres interessantes. Son existence permettra de publierprochainement SGA 5 tel quel. Il est complete par l'expose "Applications de laformule des traces aux sommes trigonometriques" qui explique comment la formuledes traces permet l'etude de sommes trigonometriques, et donne des exemples..

Leverage this example-packed, comprehensive guide for all your Python computational needs Key Features Learn the first steps within Python to highly specialized concepts Explore examples and code snippets taken from typical programming situations within scientific computing. Delve into essential computer science concepts like iterating, object-oriented programming, testing, and MPI presented in strong connection to applications within scientific computing. Book DescriptionPython has tremendous potential within the scientific computing domain. This updated edition of Scientific Computing with Python features new chapters on graphical user interfaces, efficient data processing, and parallel computing to help you perform mathematical and scientific computing efficiently using Python. This book will help you to explore new Python syntax features and create different models using scientific computing principles. The book presents Python alongside mathematical applications and demonstrates how to apply Python concepts in computing with the help of examples involving Python 3.8. You'll use pandas for basic data analysis to understand the modern needs of scientific computing, and cover data module improvements and built-in features. You'll also explore numerical computation modules such as NumPy and SciPy, which enable fast access to highly efficient numerical algorithms. By learning to use the plotting module Matplotlib, you will be able to represent your computational results in talks and publications. A special chapter is devoted to SymPy, a tool for bridging symbolic and numerical computations. By the end of this Python book, you'll have gained a solid understanding of task automation and how to implement and test mathematical algorithms within the realm of scientific computing. What you will learn Understand the building blocks of computational mathematics, linear algebra, and related Python objects Use Matplotlib to create high-quality figures and graphics to draw and visualize results Apply object-oriented programming (OOP) to scientific computing in Python Discover how to use pandas to enter the world of data processing Handle exceptions for writing reliable and usable code Cover manual and automatic aspects of testing for scientific programming Get to grips with parallel computing to increase computation speed Who this book is forThis book is for students with a mathematical background, university teachers designing modern courses in programming, data scientists, researchers, developers, and anyone who wants to perform scientific computation in Python.

"The Organization of Firms in a Global Economy" presents a new research program that is transforming the study of international trade. Driven by the availability of new micro data sets and innovative theoretical models, it focuses on the level of firms, products, and stages of production rather than on countries and industries. It addresses such questions as why only a small proportion of firms in a given industry export and why an even smaller proportion invest abroad; why exporters tend to be more productive than nonexporters; why almost one-third of international trade takes place between units of the same firm and why as much as two-thirds involves multinational firms as exporter, importer, or both; and why international trade may have been the most important driver of organizational changes in the corporation that have been taking place in the last decade.

Until a few years ago, models of international trade did not recognize the heterogeneity of firms and exporters, and could not provide good explanations of international production networks. Now such models exist and are explored in this volume.