A BOOK OF THE YEAR FOR THE GUARDIAN: 'DEEPLY PLEASURABLE' A BOOK OF THE YEAR FOR THE SPECTATOR: 'WHAT A JOY' 'Magnificent' Guardian 'A towering achivement' Financial Times 'Inventive, bold, unexpected' Sunday Times 'Everything that makes the novel worthwhile and engaging is here: warmth, wit, intelligence, love, death, high seriousness, low comedy, philosophy, subtle personal relationships and the complex interior life of human beings' Guardian 'Not since William Boyd's Any Human Heart has a novel captured the feast and famine nature of a single life with such invention and tenderness' Financial Times 'There is a pleasing sense of having grappled with the real stuff of life: loss, grief, love, desire, pain, uncertainty, confusion, joy, despair - all while having fun' The Sunday Times 'Instantly immersive, playfully inventive, effortlessly wise' Observer 'Masterly: a cabinet of curiosities and delights, packed with small wonders' Ian McEwan 'A real masterpiece. A funny, touching, profound book that made me cry like a little girl on the last page' Leila Slimani 'A remarkable accomplishment, a true gift to the world' Michael Cunningham 'Ardent, gripping, and inventive to the core' Jhumpa Lahiri Marco Carrera is 'the hummingbird,' a man with the almost supernatural ability to stay still as the world around him continues to change. As he navigates the challenges of life - confronting the death of his sister and the absence of his brother; taking care of his parents as they approach the end of their lives; raising his granddaughter when her mother, Marco's own child, can no longer be there for her; coming to terms with his love for the enigmatic Luisa - Marco Carrera comes to represent the quiet heroism that pervades so much of our everyday existence. A thrilling novel about the need to look to the future with hope and live with intensity to the very end. THE NO. 1 INTERNATIONAL BESTSELLER Over 300,000 copies sold Soon to be a major motion picture Winner of the Premio Strega Winner of the Prix du Livre Etranger Book of the Year for the Corriere della Sera

A BOOK OF THE YEAR FOR THE GUARDIAN: 'DEEPLY PLEASURABLE' A BOOK OF THE YEAR FOR THE SPECTATOR: 'WHAT A JOY' 'Magnificent' Guardian 'A towering achivement' Financial Times 'Inventive, bold, unexpected' Sunday Times 'Everything that makes the novel worthwhile and engaging is here: warmth, wit, intelligence, love, death, high seriousness, low comedy, philosophy, subtle personal relationships and the complex interior life of human beings' Guardian 'Not since William Boyd's Any Human Heart has a novel captured the feast and famine nature of a single life with such invention and tenderness' Financial Times 'There is a pleasing sense of having grappled with the real stuff of life: loss, grief, love, desire, pain, uncertainty, confusion, joy, despair - all while having fun' The Sunday Times 'Instantly immersive, playfully inventive, effortlessly wise' Observer 'Masterly: a cabinet of curiosities and delights, packed with small wonders' Ian McEwan 'A real masterpiece. A funny, touching, profound book that made me cry like a little girl on the last page' Leila Slimani 'A remarkable accomplishment, a true gift to the world' Michael Cunningham 'Ardent, gripping, and inventive to the core' Jhumpa Lahiri Marco Carrera is 'the hummingbird,' a man with the almost supernatural ability to stay still as the world around him continues to change. As he navigates the challenges of life - confronting the death of his sister and the absence of his brother; taking care of his parents as they approach the end of their lives; raising his granddaughter when her mother, Marco's own child, can no longer be there for her; coming to terms with his love for the enigmatic Luisa - Marco Carrera comes to represent the quiet heroism that pervades so much of our everyday existence. A thrilling novel about the need to look to the future with hope and live with intensity to the very end. THE NO. 1 INTERNATIONAL BESTSELLER Over 300,000 copies sold Soon to be a major motion picture Winner of the Premio Strega Winner of the Prix du Livre Etranger Book of the Year for the Corriere della Sera

Worldwide investigations on mesenchymal stromal/stem cells (MSC) have highlighted their regenerative potentials. Subsequent ex vivo & in vivo studies, with or without biomaterial combination, have explored MSC efficiency to repair damaged tissues and organs. This book investigates some of key factors on MSC biology & performance, such as the cell transportation procedures and the vasculogenesis after transplantation. One of the prerequisites for MSC introduction into clinic is their manipulation under good manufacturing practice (GMP) facilities that are often far from the operating theatre. Appropriate cell shipment conditions are poorly defined, therefore in this book we describe the impact of transportation on functional outcome focusing on bone regeneration. We then focused on an innovative approach of adipose tissue regeneration that reduced necrosis and significantly increased vasculogenesis compared with common surgical procedure for adipose tissue reconstruction based on autologous fat transfer. These data may be useful for anyone who studies MSC looking for their introduction into regenerative medicine approaches based on both their differentiation and secretory potentials